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Marsupial cathelicidins: characterization, antimicrobial activity and evolution in this unique mammalian lineage [PDF]

Frontiers in Immunology
IntroductionCathelicidins are a family of antimicrobial peptides well-known for their antimicrobial and immunomodulatory functions in eutherian mammals such as humans.
Emma Peel, Emma Peel, Adele Gonsalvez, Adele Gonsalvez, Carolyn J. Hogg, Carolyn J. Hogg, Katherine Belov, Katherine Belov   +7 more
doaj   +2 more sources

Cathelicidins Limit Intracellular Neospora caninum-Infection in Macrophages [PDF]

Pathogens
Infections with the protozoan Neospora caninum cause abortion in cattle, likely due to the parasite’s replication and excessive inflammation in the placenta.
Franco Fiorani, Priyoshi Lahiri, Rodrigo Puentes, Peter John Bradley, Dadin Prando Moore, Eduardo Ruben Cobo   +5 more
doaj   +2 more sources

Cathelicidins: Opportunities and Challenges in Skin Therapeutics and Clinical Translation [PDF]

Antibiotics
Cathelicidins are a group of cationic, amphipathic peptides that play a vital role in the innate immune response of many vertebrates, including humans.
Lenka Dzurová, Edita Holásková, Hana Pospíšilová, Gabriela Schneider Rauber, Jitka Frébortová   +4 more
doaj   +2 more sources

Exploring the Antimicrobial and Immunomodulatory Potential of Gecko-Derived Cathelicidin Gj-CATH5 [PDF]

Biomolecules
Regulating the innate immune response against infections, particularly drug-resistant bacteria, is a key focus in anti-infection therapy. Cathelicidins, found in vertebrates, are crucial for pathogen resistance.
Shasha Cai, Ningyang Gao, Junhan Wang, Jing Li   +3 more
doaj   +2 more sources

Natural and Synthetic Peptides as Alternatives to Antibiotics in Intestinal Infections—A Review [PDF]

Antibiotics
Background/Objectives: Antimicrobial peptides (AMPs), evolutionarily conserved components of innate immunity characterized by their broad-spectrum efficacy and minimal resistance development, are increasingly recognized as promising therapeutic ...
Lala Stepanyan, Monika Israyelyan, Alessandro Gori, Avetis Tsaturyan, Zhaklina Saribekyan, Kristina Hovsepyan, Tatevik Sargsyan, Raffaele Pastore, Antonio De Luca, Giovanni N. Roviello   +9 more
doaj   +2 more sources

Recent advances in the therapeutic potential of cathelicidins [PDF]

Frontiers in Microbiology
The alarming increase in antimicrobial resistance in the last decades has prompted the search for alternatives to control infectious diseases. Antimicrobial peptides (AMPs) represent a heterogeneous class of molecules with ample antibacterial, antiviral,
Maria Eduarda Souza Guerra, Brenda Vieira, Ana Paula Carvalho Thiers Calazans, Giulia Vicente Destro, Karina Melo, Emilly Rodrigues, Natalha Tedeschi Waz, Raquel Girardello, Michelle Darrieux, Thiago Rojas Converso   +9 more
doaj   +2 more sources

Expression Pattern of Cathelicidins in Dairy Cows During Endometritis and Role of Bovine Endometrial Epithelial Cells in Production of Cathelicidins

Frontiers in Veterinary Science, 2021
Endometritis is a common bacterial disease of dairy cows. Cathelicidins are host-defense peptides that play important roles in clearance of bacteria. However, the expression pattern of these peptides during endometritis is still unclear.
Yajuan Li, Yajuan Li, Xiaoyu Ma, Jie Yang, Xiaohu Wu, Zuoting Yan, Baoxiang He   +6 more
doaj   +1 more source

Genomewide Analysis and Biological Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity from Three Bat Species

Antibiotics, 2022
Cathelicidins are potent antimicrobial peptides with broad spectrum antimicrobial activity in many vertebrates and an important component of the innate immune system.
Munjeong Choi, Hye-sun Cho, Byeongyong Ahn, Somasundaram Prathap, Soundrarajan Nagasundarapandian, Chankyu Park   +5 more
doaj   +1 more source

Molecular characterization, mRNA gene expression, and antimicrobial activity of 2 new cathelicidin genes in goose

Poultry Science, 2020
Cathelicidins represent a major group of host defense peptides (HDPs) that share a highly conserved cathelin-like domain. In birds, this gene family has been identified in many species. However, no information was available in the goose until now.
Yingping Xiao, Wentao Lyu, Hua Yang, Xiaoqin Xu, Caiquan Zhou, Lizhi Lu, Long Zhang   +6 more
doaj   +1 more source

Chicken cathelicidins display antimicrobial activity against multiresistant bacteria without inducing strong resistance. [PDF]

PLoS ONE, 2013
The increased prevalence of multidrug-resistant (MDR) bacteria in combination with the relatively limited development of new antibiotics presents a serious threat to public health.
Edwin J A Veldhuizen, Ellen C Brouwer, Viktoria A F Schneider, Ad C Fluit   +3 more
doaj   +1 more source