Results 41 to 50 of about 9,499 (202)

Opossum Cathelicidins Exhibit Antimicrobial Activity Against a Broad Spectrum of Pathogens Including West Nile Virus

Frontiers in Immunology, 2020
This study aimed to characterize cathelicidins from the gray short-tailed opossum in silico and experimentally validate their antimicrobial effects against various pathogenic bacteria and West Nile virus (WNV).
Hye-sun Cho, Joori Yum, Andy Larivière, Nicolas Lévêque, Quy Van Chanh Le, ByeongYong Ahn, Hyoim Jeon, Kwonho Hong, Nagasundarapandian Soundrarajan, Jin-Hoi Kim, Charles Bodet, Chankyu Park   +11 more
doaj   +1 more source

A Paradigm of Translational Medicine [PDF]

, 2012
Antimicrobial peptides (AMPs) are small, cationic, amphiphilic peptides with broad-spectrum microbicidal activity against both bacteria and fungi. In mammals, AMPs form the first line of host defense against infections and generally play an important ...
Korting, H. C., Schäfer-Korting, M., Schöllmann, C., Stauss-Grabo, M.   +3 more
core   +1 more source

Escherichia coli expression and purification of LL37 fused to a family III carbohydrate-binding module from Clostridium thermocellum [PDF]

, 2010
The cathelicidin derived human peptide LL37 has a broad spectrum of antimicrobial and immunomodulatory activities. The large variety of biological activities makes LL37 a very promising candidate for clinical applications.
Domingues, Lucília, Gama, F. M., Ramos, Reinaldo Rodrigues   +2 more
core   +1 more source

The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production [PDF]

, 2018
Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and ...
A Al-Mamun, A Calmette, A Dijk van, A Dijk van, A Gronberg, A Kalita, A Lihme, A Nijnik, AH Achtman, AL Hilchie, Albert van Dijk, AM Does van der, AS Ferreira, B Rivas-Santiago, BA Blok, BS Graham, C Subbalakshmi, CD Fjell, Chris J. Hedegaard, CJ Hedegaard, CJ Hedegaard, CJ Hedegaard, CSF Bah, D Carlander, D Torrallardona, D Yang, D Yang, DA O’Neil, DA O’Neil, DC Speksnijder, DJ Davidson, DM Bowdish, DM Weaver, E Miraglia, E Tourneur, F Nimmerjahn, G Marano, G Vidarsson, H Liu, H Sherman, Henk P. Haagsman, I Nagaoka, J Kindrachuk, J Kleinnijenhuis, J Kovacs-Nolan, J Kovacs-Nolan, J Kovacs-Nolan, J Rohrl, J Schauber, JB Schaal, JD Heilborn, JH Es van, JL Pierce, K Chakraborty, K Chakraborty, K Moor, K Putsep, L Bandholtz, L Kannan, L Steinstraesser, L Zhang, LT Sunkara, M Akdis, M Cappelletti, M Coorens, M Coorens, M Ohno, M Ren, M Schlee, M Schlee, M Schwab, MA Hamon, MA Keller, MD Kraaij, MG Netea, MJ Alam, MM Rahman, N Mookherjee, N Mookherjee, NH Salzman, NY Yount, OE Sorensen, P Fehlbaum, P Presicce, P Sarker, P Tewary, Peter M. H. Heegaard, R Fisher, R Nocerino, R Ramos, R Raqib, RA Dorschner, RE Hancock, RE Hancock, RE Hancock, RI Lehrer, RJ Arts, RL Gallo, RL Hassfurther, RP Darveau, RS Rekha, S Caro Di, S Godden, S Saeed, SH Kim, T Cuperus, T Cuperus, TA Pham, TJ Newby, U Gerstel, V Petrov, V Virdi, VA Schneider, VK Lishko, W Jiang, WL Hurley, X Qiu, X Zeng, Y Goto   +118 more
core   +2 more sources

Cathelicidin deficiency predisposes to eczema herpeticum [PDF]

Journal of Allergy and Clinical Immunology, 2006
The cathelicidin family of antimicrobial peptides is an integral component of the innate immune response that exhibits activity against bacterial, fungal, and viral pathogens. Eczema herpeticum (ADEH) develops in a subset of patients with atopic dermatitis (AD) because of disseminated infection with herpes simplex virus (HSV).This study investigated ...
Michael D, Howell, Andreas, Wollenberg, Richard L, Gallo, Michael, Flaig, Joanne E, Streib, Cathy, Wong, Tatjana, Pavicic, Mark, Boguniewicz, Donald Y M, Leung   +8 more
openaire   +2 more sources

Cathelicidin-OA1, a novel antioxidant peptide identified from an amphibian, accelerates skin wound healing

Scientific Reports, 2018
Cathelicidins play pivotal roles in host defense. The discovery of novel cathelicidins is important research; however, despite the identification of many cathelicidins in vertebrates, few have been reported in amphibians.
Xiaoqing Cao, Ying Wang, Chunyun Wu, Xiaojie Li, Zhe Fu, Meifeng Yang, Wenxin Bian, Siyuan Wang, Yongli Song, Jing Tang, Xinwang Yang   +10 more
doaj   +1 more source

Endogenous cathelicidin production limits inflammation and protective immunity to Mycobacterium avium in mice [PDF]

, 2013
The production of antimicrobial peptides, such as the cathelicidins, plays a prominent role in the innate immune response against microbial pathogens. Cathelicidins are widely distributed amongst living organisms, and the antimicrobial peptides generated
Appelberg, R., Gallo, R. L., Gama, F. M., Rosa, G., Santos, J. C., Silva, João P., Silva-Gomes, S.   +6 more
core   +1 more source

Human Cathelicidin Production by the Cervix

PLoS ONE, 2014
hCAP18/LL-37 is the sole human cathelicidin; a family of host defence peptides with key roles in innate host defence. hCAP18/LL-37 is expressed primarily by neutrophils and epithelial cells, but its production and function in the lower genital tract is largely uncharacterised.
Frew, Lorraine, Makieva, Sofia, McKinlay, Andrew T M, McHugh, Brian J, Doust, Ann, Norman, Jane E, Davidson, Donald J, Stock, Sarah J   +7 more
openaire   +6 more sources

Cathelicidin impact on inflammatory cells.

Central-European journal of immunology, 2015
Cathelicidins, like other antimicrobial peptides, exhibit direct antimicrobial activities against a broad spectrum of microbes, including both Gram-positive and Gram-negative bacteria, enveloped viruses, and fungi. These host-derived peptides kill the invaded pathogens by perturbing their cell membranes and can neutralize biological activities of ...
Agier, Justyna, Efenberger, Magdalena, Brzezińska-Błaszczyk, Ewa   +2 more
openaire   +3 more sources

Antimicrobial Peptides: Multifunctional Drugs for Different Applications [PDF]

, 2012
Antimicrobial peptides (APs) are an important part of the innate immune system in epithelial and non-epithelial surfaces. So far, many different antimicrobial peptides from various families have been discovered in non-vertebrates and vertebrates.
Buck, Chavakis, Cole, Daher, Davidson, De Lucca, Deike Varoga, Dombrowski, Feng, Frohm, Gallo, Gao, Ghosh, Gudmundsson, Haines, Helmerhorst, Hirsch, Huang, Johansson, Julika Merres, Kazemzadeh-Narbat, Koczulla, Lande, Larrick, Lars-Ove Brandenburg, Lea-Jessica Albrecht, Liang, Lillard, Matejuk, McInturff, Nagaoka, Nijnik, Nizet, Pazgier, Putsep, Scott, Selsted, Sorensen, Steinberg, Svenson, Thomas Pufe, Travis, van der Does, van der Does, Wang, Welling, Wiese, Xiong, Yang, Yang, Yeung, Zanetti, Zasloff   +52 more
core   +1 more source