Results 51 to 60 of about 9,499 (202)
PLoS ONE, 2014 Cathelicidins, a class of gene-encoded effector molecules of vertebrate innate immunity, provide a first line of defense against microbial invasions. Although cathelicidins from mammals, birds, reptiles and fishes have been extensively studied, little is
Guiying Ling +6 more
doaj +1 more source
Past, Present, and Future of Naturally Occurring Antimicrobials Related to Snake Venoms
Animals, 2023 This review focuses on proteins and peptides with antimicrobial activity because these biopolymers can be useful in the fight against infectious diseases and to overcome the critical problem of microbial resistance to antibiotics.
Nancy Oguiura +4 more
doaj +1 more source
Cathelicidin-like Helminth Defence Molecules (HDMs) Absence of Cytotoxic, Anti-microbial and Anti-protozoan Activities Imply a Specific Adaptation to Immune Modulation [PDF]
, 2013 Host defence peptides (HDPs) are expressed throughout the animal and plant kingdoms. They have multifunctional roles in the defence against infectious agents of mammals, possessing both bactericidal and immune-modulatory activities.
A Giacometti +115 more
core +3 more sources
Immunomodulatory Properties of Defensins and Cathelicidins [PDF]
, 2006 Host defence peptides are a conserved component of the innate immune response in all complex life forms. In humans, the major classes of host defence peptides include the alpha- and beta-defensins and the cathelicidin, hCAP-18/LL-37. These peptides are expressed in the granules of neutrophils and by a wide variety of tissue types.
Bowdish, D. M. E. +2 more
openaire +2 more sources
Antimicrobial and Defense Proteins in Chronic Rhinosinusitis with Nasal Polyps
Medicina, 2023 Background and Objectives: Chronic rhinosinusitis with nasal polyps (CRSwNP) presently remains a difficult disease to manage. Antimicrobial and defense proteins are important factors that could help characterize the role of microorganisms in CRSwNP ...
Rudolfs Janis Viksne +2 more
doaj +1 more source
Destabilization of α-helical structure in solution improves bactericidal activity of antimicrobial peptides: Opposing effects on bacterial and viral targets [PDF]
, 2016 We have previously examined the mechanism of antimicrobial peptides on the outer membrane of vaccinia virus. Here we show that the formulation of peptides LL37 and magainin-2B amide in polysorbate 20 (Tween-20™) results in greater reductions in virus ...
Beck, Konrad +4 more
core +2 more sources
Activity of Cathelicidin Peptides against Simkania negevensis [PDF]
International Journal of Peptides, 2011 The in vitro activity of six cathelicidin peptides against the reference strain Z of Simkania negevensis was investigated. Five peptides—PG-1, Bac7, SMAP-29, BMAP-27, and BMAP-28—proved to be active at very low concentrations (1 to 0.1 μg/mL), while LL-37 cathelicidin was ineffective even at a concentration of 100 μg/mL. In comparison to chlamydiae, S.
DONATI, MANUELA +8 more
openaire +3 more sources
Antibiotics, 2022 Host defense peptides (HDPs) represent an alternative way to address the emergence of antibiotic resistance. Crocodylians are interesting species for the study of these molecules because of their potent immune system, which confers high resistance to ...
Felix L. Santana +11 more
doaj +1 more source
Natural Antimicrobial Peptides: Pleiotropic Molecules in Host Defense [PDF]
, 2013 Natural antimicrobial peptides (AMPs) are small cationic molecules that display antimicrobial activity against a wide range of bacteria, fungi and viruses.
Maffia, Paulo Cesar +2 more
core +1 more source
mBio, 2019 All metazoans produce antimicrobial peptides (AMPs) that have both broad antimicrobial and immunomodulatory activity. Cathelicidins are AMPs that preferentially kill Gram-negative bacteria in vitro, purportedly by assembling into higher-order structures ...
Dean A. Rowe-Magnus +4 more
doaj +1 more source