Serum and Synovial Levels of Cathepsin G and Cathepsin K in Patients with Psoriatic Arthritis and Their Correlation with Disease Activity Indices [PDF]
Diagnostics, 2023 This retrospective case-control study examined the relationship between the serum and synovial levels of cathepsin G (CatG) and cathepsin K (CatK) in patients with psoriatic arthritis (PsA) and their association with disease activity.
Stanislava Dimitrova Popova-Belova +3 more
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The Inhibition of Cathepsin G on Endometrial Explants With Endometrosis in the Mare [PDF]
Frontiers in Veterinary Science, 2020 Although proteases found in neutrophil extracellular traps (NETs) have antimicrobial properties, they also stimulate collagen type 1 (COL1) production by the mare endometrium, contributing for the development of endometrosis.
Ana Amaral +10 more
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Homogeneous, Synthetic, Non-Saccharide Glycosaminoglycan Mimetics as Potent Inhibitors of Human Cathepsin G [PDF]
Biomolecules, 2023 Cathepsin G (CatG) is a pro-inflammatory neutrophil serine protease that is important for host defense, and has been implicated in several inflammatory disorders.
Daniel K. Afosah +7 more
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SERPINA3C ameliorates adipose tissue inflammation through the Cathepsin G/Integrin/AKT pathway [PDF]
Molecular Metabolism, 2022 Objective: Due to the increasing prevalence of obesity and insulin resistance, there is an urgent need for better treatment of obesity and its related metabolic disorders. This study aimed to elucidate the role of SERPINA3C, an adipocyte secreted protein,
Bai-Yu Li +4 more
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Fenugreek inhibits cathepsin G activity and suppresses the progression of malignant phenotypes in MCF-7 cells [PDF]
Biochemistry and Biophysics ReportsSpices and herbs, which are derived from natural botanical sources, contain many bioactive compounds and play an important role in human health. The general and specific health benefits of these spices and herbs include anti-inflammatory, antioxidant ...
Kazunari Tanigawa +13 more
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The Crosstalk Between Cancer Cells and Neutrophils Enhances Hepatocellular Carcinoma Metastasis via Neutrophil Extracellular Traps-Associated Cathepsin G Component: A Potential Therapeutic Target [PDF]
Journal of Hepatocellular Carcinoma, 2021 Xiangqian Guan, Yuyan Lu, Heping Zhu, Shuqi Yu, Wenxiu Zhao, Xiaoqin Chi, Chengrong Xie, Zhenyu Yin Department of Hepatobiliary Surgery, Zhongshan Hospital, Xiamen University, Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular ...
Guan X +7 more
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The Inhibitory Effect of Noscapine on the In Vitro Cathepsin G-Induced Collagen Expression in Equine Endometrium [PDF]
Life, 2021 Cathepsin G (CAT) is a protease released by neutrophils when forming neutrophil extracellular traps that was already associated with inducing type I collagen (COL1) in equine endometrium in vitro. Endometrosis is a fibrotic condition mainly characterized
Ana Amaral +7 more
doaj +2 more sources
Neutrophil cathepsin G and risk of cardiovascular events in patients with diabetes mellitus [PDF]
Cardiovascular DiabetologyBackground Type 2 diabetes mellitus (T2DM) is a major risk factor for atherosclerosis and cardiovascular events (CVEs), partly due to increased platelet activation and inflammation.
Francesco Baratta +12 more
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Neutrophil Cathepsin G and Tumor Cell RAGE Facilitate Neutrophil Anti-Tumor Cytotoxicity [PDF]
OncoImmunology, 2019 Neutrophils are a heterogeneous population of myeloid cells which may either promote or hinder tumor growth and progression. Anti-tumor neutrophils have the capacity to kill tumor cells in a contact-dependent manner.
Ronit Vogt Sionov +5 more
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Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation [PDF]
Cell Reports, 2019 Summary: Neutrophil granule serine proteases contribute to immune responses through cleavage of microbial toxins and structural proteins. They induce tissue damage and modulate inflammation if levels exceed their inhibitors.
Sabrina Sofia Burgener +5 more
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