Triterpene Acids from Frankincense and Semi-Synthetic Derivatives That Inhibit 5-Lipoxygenase and Cathepsin G [PDF]
Molecules, 2018 Age-related diseases, such as osteoarthritis, Alzheimer’s disease, diabetes, and cardiovascular disease, are often associated with chronic unresolved inflammation. Neutrophils play central roles in this process by releasing tissue-degenerative proteases,
Andreas Koeberle +10 more
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Cathepsin G promotes arteriovenous fistula maturation by positively regulating the MMP2/MMP9 pathway [PDF]
Renal FailureBackground Arteriovenous fistula (AVF) is currently the preferred vascular access for hemodialysis patients. However, the low maturation rate of AVF severely affects its use in patients.
Lemei Hu +7 more
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Cathepsin G Degrades Staphylococcus aureus Biofilms. [PDF]
J Infect Dis, 2021 Abstract Polymorphonuclear leukocytes (PMN) phagocytose and kill individual bacteria but are far less efficient when challenged with bacterial aggregates. Consequently, growth within a biofilm affords Staphylococcus aureus some protection but PMN penetrate S.
Kavanaugh JS +3 more
europepmc +4 more sources
Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G. [PDF]
PLoS ONE, 2016 Protease-mediated degradation of proteins is critical in a plethora of physiological processes. Neutrophils secrete serine proteases including cathepsin G (CatG), neutrophile elastase (NE), and proteinase 3 (PR3) together with lactoferrin (LF) as a first
Steffen Eipper +11 more
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Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I. [PDF]
, 2016 BackgroundCardiovascular disease, a progressive manifestation of α-L-iduronidase deficiency or mucopolysaccharidosis type I, continues in patients both untreated and treated with hematopoietic stem cell transplantation or intravenous enzyme replacement ...
Dickson, Patricia I +7 more
core +16 more sources
Cathepsin G-dependent modulation of platelet thrombus formation in vivo by blood neutrophils. [PDF]
PLoS ONE, 2013 Neutrophils are consistently associated with arterial thrombotic morbidity in human clinical studies but the causal basis for this association is unclear.
Nauder Faraday +7 more
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Status and future directions of anti-metastatic cancer nanomedicines for the inhibition of cathepsin L [PDF]
, 2020 Angiogenesis, tissue invasion and metastasis in the tumour microenvironment are all critical hallmarks of cancer. Upregulation of cathepsin L plays an important role in angiogenesis and metastasis through its ability to degrade the extracellular matrix ...
Pranjol, Md Zahidul I +3 more
core +2 more sources
Cathepsin G binds to human lymphocytes [PDF]
Journal of Leukocyte Biology, 1997 Abstract Cathepsin G is a serine protease located in the azurophil granules of neutrophils. We have shown previously that cathepsin G stimulates human lymphocytes. In this study, we demonstrate that cathepsin G exhibits specific, saturable and reversible binding to lymphocytes: B cells, CD4+ T cells, CD8+ T cells, and natural killer (NK)
T, Yamazaki, Y, Aoki
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Myofibrillar Protein Oxidation in Immersion-Frozen Red Shrimp (Solenocera crassicornis) during Frozen Storage: Analysis Based on Changes of Endogenous Enzyme Activity [PDF]
Shipin Kexue, 2023 A comparative analysis of the changes in indicators of myofibrillar protein oxidation and the activities of cathepsins B, H and in red shrimp during frozen storage after immersion freezing (?18 and ?30 ℃) and refrigerator freezing (?18 and ?30 ℃) was ...
XU Dan, Han Yue, Zheng Bin, Deng Shanggui, Chen Xuechang, Zhang Xiaojun
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Human cathepsin G. Catalytic and immunological properties [PDF]
Biochemical Journal, 1976 1. The specificity of cathepsin G, a neutral proteinase from human spleen, was examined by use of low-molecular-weight substrates. The enzyme was found to hydrolyse several synthetic substrates also hydrolysed by chymotrypsin, but with different kinetic constants. 2.
P M, Starkey, A J, Barrett
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