Results 81 to 90 of about 106,246 (275)

Expression and Localization of Cathepsins B, D, and G in Dupuytren’s Disease

Plastic and Reconstructive Surgery, Global Open, 2018
Background:. The pathogenesis of Dupuytren’s disease (DD) remains unclear. An embryonic stem cell (ESC)–like population in the endothelium of the microvessels around tissues that expresses components of the renin-angiotensin system (RAS) has been ...
Kirin Tan, MB ChB, Helen D. Brasch, BMedSc, MBChB, Bede van Schaijik, BTech (Hons), James R. Armstrong, MBBS, MD, Reginald W. Marsh, PhD, Paul F. Davis, PhD, Swee T. Tan, MBBS, PhD, Tinte Itinteang, MBBS, PhD   +7 more
doaj   +1 more source

In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. [PDF]

, 2010
BackgroundCruzain, the major cysteine protease of Trypanosoma cruzi, is an essential enzyme for the parasite life cycle and has been validated as a viable target to treat Chagas' disease.
Brinen, Linda S, Chen, Yen Ting, Doyle, Patricia S, Hansell, Elizabeth, Kerr, Iain D, McKerrow, James H, Roush, William R   +6 more
core   +3 more sources

Effective DNA Inhibitors of Cathepsin G by In Vitro Selection [PDF]

International Journal of Molecular Sciences, 2008
Cathepsin G (CatG) is a chymotrypsin-like protease released upon degranulation of neutrophils. In several inflammatory and ischaemic diseases the impaired balance between CatG and its physiological inhibitors leads to tissue destruction and platelet aggregation. Inhibitors of CatG are suitable for the treatment of inflammatory diseases and procoagulant
GATTO, BARBARA, VIANINI E, LUCATELLO L, SISSI, CLAUDIA, MOLTRASIO D, PESCADOR R, PORTA R, PALUMBO, MANLIO   +7 more
openaire   +3 more sources

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Differential neuroproteomic and systems biology analysis of spinal cord injury [PDF]

, 2016
Acute spinal cord injury (SCI) is a devastating condition with many consequences and no known effective treatment. Although it is quite easy to diagnose traumatic SCI, the assessment of injury severity and projection of disease progression or recovery ...
Bramlett, Helen M, Das, Jyotirmoy H, Dietrich, W. Dalton, Moghieb, Ahmed, Selig, Tyler, Wang, Kevin K. W, Wang, Michael S, Yang, Zhihui, Yost, Richard A   +8 more
core   +2 more sources

Recombinant aprotinin homologue with new inhibitory specificity for cathepsin G [PDF]

European Journal of Biochemistry, 1991
The substitution of amino acids in the reactive site of aprotinin, a bovine serine proteinase inhibitor with potent activity against trypsin, plasmin and tissue kallikrein, led to a change in specificity of the inhibitor.Twelve new aprotinin variants prepared by recombinant DNA technology and expressed in Escherichia coli clearly demonstrated that the ...
BRINKMANN, T, SCHNIERER, S, Tschesche, Harald   +2 more
openaire   +3 more sources

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis

Advanced Science, EarlyView.
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai, Mingchao Zhang, Le Liu, Lide Tao, Chenyang Xu, Hao Chai, Xin Shi, Yin Wang, Xiaopei Zhang, Qiong Chen, Dong Liu, Jinyu Bai, Chang She, Xiaozhong Zhou, Cong Cao, Huajian Shan   +15 more
wiley   +1 more source

Exploring the relationship between cathepsin and age-related macular degeneration using Mendelian randomization

Frontiers in Medicine
PurposeAge-related macular degeneration (AMD) is the leading cause of low vision and even blindness in the elderly population worldwide. However, no studies have been conducted to analyze the causal relationship between the cathepsin family and AMD.
Qiuyuan Wang, Qiuyuan Wang, Shanjun Cai
doaj   +1 more source

Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor [PDF]

, 2011
Berberine, an isoquinoline alkaloid derived from plants, is a traditional medicine for treating bacterial diarrhea and intestinal parasite infections. Although berberine has recently been shown to suppress growth of several tumor cell lines, information ...
D. Brent Polk, Fang Yan, Hamwei Cao, Keith Wilson, Lihong Wang, Liping Liu, Rupesh Chaturvedi, Tianhui Hu, Yan Shi   +8 more
core   +1 more source

Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis [PDF]

, 2011
Mutations in the cathepsin D (CTSD) gene cause an aggressive neurodegenerative disease (congenital neuronal ceroid lipofuscinosis) that leads to early death. Recent evidence suggests that presynaptic abnormalities play a major role in the pathogenesis of
Andrew Edwards, Ann K. Wright, Belly, Cepeda, Garborg, Jaana Tyynelä, Jonathan D. Cooper, Klapstein, Koike, Sabine Koch, Saftig, Svetlana M. Molchanova, Thomas H. Gillingwater, Tomi Taira   +13 more
core   +1 more source