Results 21 to 30 of about 44,977 (257)

Unraveling the architecture of caveolae [PDF]

Proceedings of the National Academy of Sciences, 2016
The eukaryotic cell surface is composed of many distinct membrane domains that are formed by the cooperative interactions of different proteins and lipids. These domains are important for membrane trafficking and cell signaling and are modulated in turn by changes in the cell environment. Caveolae (“little caves”) are ∼60-nm membrane invaginations (Fig.
Parton, Robert G., Collins, Brett M.
openaire   +4 more sources

Clinicopathological Significance and Prognostic Value of the Caveolae Constitutive Proteins Dynamin-2 and Caveolin-1 in Oral Squamous Cell Carcinoma. [PDF]

J Oral Pathol Med
ABSTRACT Background We investigated the clinicopathological significance of the expression of two caveolae component proteins, dynamin‐2 (DNM2) and caveolin‐1 (CAV1), in primary tumors of patients with oral squamous cell carcinoma (OSCC). Methods Immunohistochemical staining for DNM2 and CAV1 was performed on resected primary tumor specimens from 80 ...
Kishikawa Y, Kato K, Hakoda K, Funaki H, Kobayashi H, Kobayashi Y, Miyazawa H, Noguchi N, Kawashiri S.   +8 more
europepmc   +2 more sources

Retrograde transport pathways utilised by viruses and protein toxins [PDF]

, 2006
A model has been presented for retrograde transport of certain toxins and viruses from the cell surface to the ER that suggests an obligatory interaction with a glycolipid receptor at the cell surface. Here we review studies on the ER trafficking cholera
Easton, A. J. (Andrew J.), Lord, Mike, Roberts, L. M. (Lynne M.), Smith, Daniel C., Spooner, Robert A.   +4 more
core   +2 more sources

EHD2 is a mechanotransducer connecting caveolae dynamics with gene transcription [PDF]

, 2018
Caveolae are small invaginated pits that function as dynamic mechanosensors to buffer tension variations at the plasma membrane. Here we show that under mechanical stress, the EHD2 ATPase is rapidly released from caveolae, SUMOylated, and translocated to
Alexandre Grassart, Ariotti, Bolte, Catherine Coirault, Cesar Augusto Valades-Cruz, Chan, Chen, Cheng, Christine Viaris de Lesegno, Christophe Lamaze, Cédric M. Blouin, Darius Köster, DuFort, Edelstein, Enserink, Fernández-Sánchez, Gambin, Garcia, Geiss-Friedlander, Gervásio, Goetz, Heuser, Hoernke, Iskratsch, Joshi, Kovtun, Lamaze, Lamaze, Li, Lim, Liu, Lo, Ludger Johannes, Ludwig, Morén, Nassar, Nassoy, Otsu, Palade, Paolo Pierobon, Pekar, Pierre Bost, Satish Kailasam Mani, Sheetz, Shi, Sinha, Stoeber, Stoeber, Stéphane Vassilopoulos, Stéphanie Torrino, Subramanian, Söderberg, Tolić-Nørrelykke, Valérie Chambon, Vassili Soumelis, Wei-Wei Shen, Yamada, Yang, Yeow   +58 more
core   +3 more sources

Spelunking for lipids in caveolae [PDF]

Journal of Biological Chemistry, 2017
Phosphatidylserine (PtdSer) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) have been implicated in the maintenance of caveolae, but direct evidence that these lipids are required for normal caveolar structure and dynamics in living cells has been lacking. A new study by Fairn and colleagues uses sophisticated tools to perturb specific lipids
openaire   +3 more sources

Energy and Dynamics of Caveolae Trafficking [PDF]

Frontiers in Cell and Developmental Biology, 2021
Caveolae are 70–100 nm diameter plasma membrane invaginations found in abundance in adipocytes, endothelial cells, myocytes, and fibroblasts. Their bulb-shaped membrane domain is characterized and formed by specific lipid binding proteins including Caveolins, Cavins, Pacsin2, and EHD2.
Claudia Matthaeus, Justin W. Taraska
openaire   +3 more sources

Plasma from Volunteers Breathing Helium Reduces Hypoxia-Induced Cell Damage in Human Endothelial Cells-Mechanisms of Remote Protection Against Hypoxia by Helium. [PDF]

, 2019
PurposeRemote ischemic preconditioning protects peripheral organs against prolonged ischemia/reperfusion injury via circulating protective factors. Preconditioning with helium protected healthy volunteers against postischemic endothelial dysfunction.
Augustijn, Quinten JJ, Hollmann, Markus W, Konkel, Moritz, Oei, Gezina TML, Patel, Hemal H, Preckel, Benedikt, Smit, Kirsten F, Weber, Nina C   +7 more
core   +1 more source

Lifestyle intervention in individuals with impaired glucose regulation affects Caveolin-1 expression and DNA methylation [PDF]

, 2020
© 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Aims: We investigated whether a lifestyle intervention could influence expression and DNA methylation of diabetes-related genes in patients with impaired ...
Adam, S., Dalton, Caroline, Donn, R.P., Fachim, H.A., Gibson, J.M., Heald, A.H., Malipatil, N., Moreno, G.Y.C., Siddals, K., Soran, H.   +9 more
core   +1 more source

Cell Propagation of Cholera Toxin CTA ADP-Ribosylating Factor by Exosome Mediated Transfer [PDF]

, 2018
In this study, we report how the cholera toxin (CT) A subunit (CTA), the enzyme moiety responsible for signaling alteration in host cells, enters the exosomal pathway, secretes extracellularly, transmits itself to a cell population.
Boussadia, Zaira, Carollo, Maria, Fabbri, Alessia, Falchi, Mario, Fecchi, Katia, Fiani, Maria Luisa, Gallina, Angelo, Palermo, Angela, Parisi, Sofia, Pasquini, Luca, Sargiacomo, Massimo, Zanetti, Cristiana   +11 more
core   +1 more source

Intracellular trafficking and cellular uptake mechanism of PHBV nanoparticles for targeted delivery in epithelial cell lines [PDF]

, 2017
Indexación: Web of Science; Scopus; Scielo.Background: Nanotechnology is a science that involves imaging, measurement, modeling and a manipulation of matter at the nanometric scale.
Cabana-Brunod, M, Fuentes, JA, Gonzalez-Nilo, FD, Llancalahuen, FM, Maldonado-Biermann, F, Marquez-Miranda, V, Otero, C, Penaloza, JP, Reyes-Ramirez, R, Rodriguez-Diaz, M, Velasquez, LA, Vilos, C   +11 more
core   +1 more source