Results 1 to 10 of about 34,322 (140)

Different Regulations of ROM2 and LRG1 Expression by Ccr4, Pop2, and Dhh1 in the Saccharomyces cerevisiae Cell Wall Integrity Pathway [PDF]

mSphere, 2016
Ccr4, a component of the Ccr4-Not cytoplasmic deadenylase complex, is known to be required for the cell wall integrity (CWI) pathway in the budding yeast Saccharomyces cerevisiae.
Xia Li, Tetsuro Ohmori, Kaoru Irie, Yuichi Kimura, Yasuyuki Suda, Tomoaki Mizuno, Kenji Irie   +6 more
doaj   +2 more sources

Multivalent interactions with CCR4–NOT and PABPC1 determine mRNA repression efficiency by tristetraprolin [PDF]

Nature Communications
Tristetraprolin family of proteins regulate mRNA stability by binding to specific AU-rich elements in transcripts. This binding promotes the shortening of the mRNA poly(A) tail, or deadenylation, initiating mRNA degradation.
Filip Pekovic, Wi S. Lai, Joshua Corbo, Stephanie N. Hicks, Keiko Luke, Perry J. Blackshear, Eugene Valkov   +6 more
doaj   +2 more sources

T helper cell subsets specific for pseudomonas aeruginosa in healthy individuals and patients with cystic fibrosis [PDF]

, 2014
Background: We set out to determine the magnitude of antigen-specific memory T helper cell responses to Pseudomonas aeruginosa in healthy humans and patients with cystic fibrosis.
AJ Vallis, AL Gurney, B Stockinger, BJ Stoodley, CE Zielinski, DG Downey, Dominik Hartl, EV Acosta-Rodriguez, F Ratjen, GF Sonnenberg, GF Sonnenberg, Gordon MacGregor, GP Priebe, Hannah K. Bayes, HL Tan, K Chen, K Wolk, L Martinez-Solano, M Brodlie, M Wuthrich, N Ota, N Rieber, PJ Dubin, R Basu, RB Markham, RG Wunderink, RT Sadikot, S Eyerich, S Trifari, SJ Aujla, SL Gaffen, SM Rowe, Stephen Bicknell, T Duhen, T Sawa, Tom J. Evans, Y Zheng   +36 more
core   +14 more sources

CCR4 Blockade Diminishes Intratumoral Macrophage Recruitment and Augments Survival of Syngeneic Pancreatic Cancer-Bearing Mice

Biomedicines, 2023
Pancreatic cancer is known for its tumor microenvironment (TME), which is rich in stromal and immune cells supporting cancer growth and therapy resistance.
Aydar Khabipov, Dung Nguyen Trung, Julia van der Linde, Lea Miebach, Maik Lenz, Felix Erne, Wolfram von Bernstorff, Tobias Schulze, Stephan Kersting, Sander Bekeschus, Lars Ivo Partecke   +10 more
doaj   +1 more source

FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor Microenvironment by Inducing CCR4 Expression in Breast Cancer

Frontiers in Immunology, 2022
Infiltrating T-regulatory cells in the tumor microenvironment is a key impediment to immunotherapy and is linked to a poor prognosis. We found that tumor-infiltrating Tregs express a higher expression of the chemokine receptor CCR4 than peripheral Tregs ...
Tania Sarkar, Subhanki Dhar, Dwaipayan Chakraborty, Subhadip Pati, Sayantan Bose, Abir K. Panda, Udit Basak, Sourio Chakraborty, Sumon Mukherjee, Aharna Guin, Kuladip Jana, Diptendra K. Sarkar, Gaurisankar Sa   +12 more
doaj   +1 more source

CCR4‐IL2 bispecific immunotoxin is more effective than brentuximab for targeted therapy of cutaneous T‐cell lymphoma in a mouse CTCL model

FEBS Open Bio, 2023
Cutaneous T‐cell lymphoma (CTCL) encompasses two main subtypes: mycosis fungoides and Sezary syndrome. Global response rates for the systemic treatment of mycosis fungoides and Sezary syndrome are approximately 30%, and none of these treatments are ...
Zhaohui Wang, Jihong Ma, Huiping Zhang, Rashmi Ramakrishna, Danielle Mintzlaff, David W. Mathes, Elizabeth A. Pomfret, M. Scott Lucia, Dexiang Gao, Bradley M. Haverkos, Zhirui Wang   +10 more
doaj   +1 more source

Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4

Journal for ImmunoTherapy of Cancer, 2020
Background Checkpoint inhibitors (CPIs) such as anti-PD(L)-1 and anti-CTLA-4 antibodies have resulted in unprecedented rates of antitumor responses and extension of survival of patients with a variety of cancers.
Brian Wong, Dirk G Brockstedt, Lisa A Marshall, Sachie Marubayashi, Aparna Jorapur, Scott Jacobson, Mikhail Zibinsky, Omar Robles, Dennis Xiaozhou Hu, Jeffrey J Jackson, Deepa Pookot, Jerick Sanchez, Martin Brovarney, Angela Wadsworth, David Chian, David Wustrow, Paul D Kassner, Gene Cutler, Oezcan Talay   +18 more
doaj   +1 more source

Bispecific human IL2‐CCR4 immunotoxin targets human cutaneous T‐cell lymphoma

Molecular Oncology, 2020
The majority of clinically diagnosed cutaneous T‐cell lymphomas (CTCL) highly express the cell‐surface markers CC chemokine receptor 4 (CCR4) and/or CD25.
Haoyu Wang, Zhaohui Wang, Huiping Zhang, Zeng Qi, Ariel C. Johnson, David Mathes, Elizabeth A. Pomfret, Erin Rubin, Christene A. Huang, Zhirui Wang   +9 more
doaj   +1 more source

SPT5 affects the rate of mRNA degradation and physically interacts with CCR4 but does not control mRNA deadenylation [PDF]

, 2011
The CCR4-NOT complex has been shown to have multiple roles in mRNA metabolism, including that of transcriptional elongation, mRNA transport, and nuclear exosome function, but the primary function of CCR4 and CAF1 is in the deadenylation and degradation ...
Chiang, Yueh-Chin, Cui, Yajun, Denis, Clyde L., Lee, Darren J., Viswanathan, Palaniswamy   +4 more
core   +2 more sources

Ccr4-not regulates RNA polymerase I transcription and couples nutrient signaling to the control of ribosomal RNA biogenesis. [PDF]

PLoS Genetics, 2015
Ribosomal RNA synthesis is controlled by nutrient signaling through the mechanistic target of rapamycin complex 1 (mTORC1) pathway. mTORC1 regulates ribosomal RNA expression by affecting RNA Polymerase I (Pol I)-dependent transcription of the ribosomal ...
R Nicholas Laribee, Amira Hosni-Ahmed, Jason J Workman, Hongfeng Chen   +3 more
doaj   +1 more source