Results 11 to 20 of about 22,248 (218)
RNF219 regulates CCR4-NOT function in mRNA translation and deadenylation [PDF]
Scientific Reports, 2022 Post-transcriptional regulatory mechanisms play a role in many biological contexts through the control of mRNA degradation, translation and localization.
Aude Guénolé +7 more
doaj +7 more sources
The Regulatory Properties of the Ccr4–Not Complex [PDF]
Cells, 2020 The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression.
Nafiseh Chalabi Hagkarim, Roger J. Grand
doaj +3 more sources
The architecture of the Schizosaccharomyces pombe CCR4-NOT complex [PDF]
Nature Communications, 2016 CCR4-NOT is a protein complex involved in a variety of important genetic processes. Here, the authors report the mid-resolution structure of this complex, and model the positions and contacts between the subunits, providing structural support for the ...
Marta Ukleja +7 more
doaj +4 more sources
Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex [PDF]
Frontiers in Genetics, 2013 The shortening of the poly(A) tail of cytoplasmic mRNA (deadenylation) is a pivotal step in the regulation of gene expression in eukaryotic cells. Deadenylation impacts on both regulated mRNA decay as well as the rate of mRNA translation.
Gerlof Sebastiaan Winkler +1 more
doaj +3 more sources
Ccr4–Not complex reduces transcription efficiency in heterochromatin [PDF]
Nucleic Acids Research, 2021 Abstract Heterochromatic silencing is thought to occur through a combination of transcriptional silencing and RNA degradation, but the relative contribution of each pathway is not known. In this study, we analyzed RNA Polymerase II (RNA Pol II) occupancy and levels of nascent and steady-state RNA in different mutants of ...
Pablo Monteagudo-Mesas +5 more
openaire +2 more sources
Human Ccr4–Not complexes contain variable deadenylase subunits [PDF]
Biochemical Journal, 2009 The Ccr4–Not complex is evolutionarily conserved and important for regulation of mRNA synthesis and decay. The composition of the yeast complex has been well described. Orthologues of the yeast Ccr4–Not components have been identified in human cells including multiple subunits with mRNA deadenylase activity.
Lau, N.C. +6 more
openaire +3 more sources
The CCR4–NOT Deadenylase Complex Maintains Adipocyte Identity [PDF]
International Journal of Molecular Sciences, 2019 Shortening of poly(A) tails triggers mRNA degradation; hence, mRNA deadenylation regulates many biological events. In the present study, we generated mice lacking the Cnot1 gene, which encodes an essential scaffold subunit of the CCR4–NOT deadenylase complex in adipose tissues (Cnot1-AKO mice) and we examined the role of CCR4–NOT in adipocyte function.
Akinori Takahashi +7 more
openaire +2 more sources
Regulation of eukaryotic mRNA deadenylation and degradation by the Ccr4-Not complex
Frontiers in Cell and Developmental Biology, 2023 Accurate and precise regulation of gene expression programmes in eukaryotes involves the coordinated control of transcription, mRNA stability and translation.
Lorenzo Pavanello +2 more
doaj +1 more source
Alternative splicing of CNOT7 diversifies CCR4–NOT functions [PDF]
Nucleic Acids Research, 2017 The CCR4-associated factor CAF1, also called CNOT7, is a catalytic subunit of the CCR4-NOT complex, which has been implicated in all aspects of the mRNA life cycle, from mRNA synthesis in the nucleus to degradation in the cytoplasm. In human cells, alternative splicing of the CNOT7 gene yields a second CNOT7 transcript leading to the formation of a ...
Chapat, Clément +6 more
openaire +4 more sources
The Ccr4-Not Complex Regulates Skn7 through Srb10 Kinase [PDF]
Eukaryotic Cell, 2007 ABSTRACT The Ccr4-Not complex is a multifunctional regulatory platform composed of nine subunits that controls diverse cellular events including mRNA degradation, protein ubiquitination, and transcription. In this study, we identified the yeast Saccharomyces cerevisiae osmotic and oxidative stress ...
Lenssen, Eve +4 more
openaire +3 more sources