The 5' → 3' exoribonuclease XRN1/Pacman and its functions in cellular processes and development [PDF]
, 2012 XRN1 is a 5' → 3' processive exoribonuclease that degrades mRNAs after they have been decapped. It is highly conserved in all eukaryotes, including homologs in Drosophila melanogaster (Pacman), Caenorhabditis elegans (XRN1), and Saccharomyces cerevisiae (
Jones, Christopher Iain +2 more
core +1 more source
Silencing of CCR4-NOT complex subunits affects heart structure and function [PDF]
Disease Models & Mechanisms, 2020 ABSTRACT The identification of genetic variants that predispose individuals to cardiovascular disease and a better understanding of their targets would be highly advantageous. Genome-wide association studies have identified variants that associate with QT-interval length (a measure of myocardial repolarization).
Lisa Elmén +13 more
openaire +3 more sources
Insights into the structure and architecture of the CCR4-NOT complex
Frontiers in Genetics, 2014 The CCR4-NOT complex is a highly conserved, multifunctional machinery with a general role in controlling mRNA metabolism. It has been implicated in a number of different aspects of mRNA and protein expression, including mRNA degradation, transcription ...
Kun eXu +4 more
doaj +1 more source
Specific recognition and ubiquitination of translating ribosomes by mammalian CCR4–NOT
Nature Structural & Molecular Biology, 2023 Translation affects messenger RNA stability and, in yeast, this is mediated by the Ccr4-Not deadenylation complex. The details of this process in mammals remain unclear. Here, we use cryogenic electron microscopy (cryo-EM) and crosslinking mass spectrometry to show that mammalian CCR4-NOT specifically recognizes ribosomes that are stalled during ...
Eva Absmeier +5 more
openaire +2 more sources
The cellular roles of Ccr4-NOT in model and pathogenic fungi – implications for fungal virulence
Frontiers in Genetics, 2013 The fungal Ccr4-NOT complex has been implicated in orchestrating gene expression networks that impact on pathways key for virulence in pathogenic species.
John C. Panepinto +2 more
doaj +1 more source
CCR4 1014C/T and CCL22 16C/A Genetic Variations in Iranian Patients with Thyroid Cancer [PDF]
Middle East Journal of Cancer, 2022 Background: The aim of this study was to investigate the association between thyroid cancer and 16C/A single nucleotide polymorphism (SNP) in C-C motif chemokine 22 (CCL22) as well as 1014C/T SNP in C-C chemokine receptor type 4 (CCR4).Method: In this ...
Mohammad Hossein Dabbaghmanesh +5 more
doaj +1 more source
The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria [PDF]
, 2005 The mitochondrial division machinery regulates mitochondrial dynamics and consists of Fis1p, Mdv1p, and Dnm1p. Mitochondrial division relies on the recruitment of the dynamin-related protein Dnm1p to mitochondria.
Chan, David C. +2 more
core +3 more sources
Ccr4‐Not complex directly regulates transcription elongation
The FASEB Journal, 2010 Many functions have been ascribed to the Ccr4‐Not complex. First described many years ago as a potential regulator of preinitiation complex (PIC) formation, more recently, a large body of evidence indicates it is predominantly cytoplasmic and regulates deadenylation of mRNA and ubiquitylation of substrates in ...
Joseph C Reese +3 more
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The structural basis for deadenylation by the CCR4-NOT complex [PDF]
Protein & Cell, 2010 The CCR4-NOT complex is a highly conserved, multifunctional machinery controlling mRNA metabolism. Its components have been implicated in several aspects of mRNA and protein expression, including transcription initiation, elongation, mRNA degradation, ubiquitination, and protein modification.
Mark, Bartlam, Tadashi, Yamamoto
openaire +2 more sources
The influence of microRNAs and poly(A) tail length on endogenous mRNA–protein complexes [PDF]
, 2017 Background: All mRNAs are bound in vivo by proteins to form mRNA-protein complexes (mRNPs), but changes in the composition of mRNPs during posttranscriptional regulation remain largely unexplored.
Bartel, David +9 more
core +1 more source