Results 131 to 140 of about 13,668 (163)
HIPK family kinases bind and regulate the function of the CCR4-NOT complex. [PDF]
Mol Biol Cell, 2016 Rodriguez-Gil A +8 more
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Human pumilio proteins use fuzzy multivalent hydrophobic interactions to recruit the CCR4-NOT deadenylase complex to repress mRNAs. [PDF]
J Biol ChemDunshee EB +12 more
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Reconstitution of Targeted Deadenylation by the Ccr4-Not Complex and the YTH Domain Protein Mmi1.
Cell Rep, 2016 Stowell JAW +5 more
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Gene, 2012
The Ccr4-Not complex is a unique, essential and conserved multi-subunit complex that acts at the level of many different cellular functions to regulate gene expression. Two enzymatic activities, namely ubiquitination and deadenylation, are provided by different subunits of the complex.
Collart, Martine, Panasenko, Olesya
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The Ccr4-Not complex is a unique, essential and conserved multi-subunit complex that acts at the level of many different cellular functions to regulate gene expression. Two enzymatic activities, namely ubiquitination and deadenylation, are provided by different subunits of the complex.
Collart, Martine, Panasenko, Olesya
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Novel roles of the
The CCR4–NOT complex is a multi‐subunit protein complex evolutionarily conserved across eukaryotes which regulates several aspects of gene expression. A fascinating model is emerging in which this complex acts as a regulation platform, controlling gene products ‘from birth to death’ through the coordination of different cellular machineries involved in
Clément, Chapat, Laura, Corbo
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Deadenylation of cytoplasmic mRNA by the mammalian Ccr4–Not complex
Biochemical Society Transactions, 2012The Ccr4–Not complex is one of the major deadenylase factors present in eukaryotic cells. This multi-subunit protein complex is composed of at least seven stably associated subunits in mammalian cells including two enzymatic deadenylase subunits: one DEDD (Asp-Glu-Asp-Asp)-type deadenylase (either CNOT7/human Caf1/Caf1a or CNOT8/human Pop2/Caf1b/Calif)
Rachel, Doidge +3 more
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The essential function of not1 lies within the Ccr4-not complex
Journal of Molecular Biology, 2000The five Saccharomyces cerevisiae Not proteins are associated with the Ccr4 and Caf1 proteins in 1.2 MDa and 2 MDa complexes. The Not proteins have been proposed to repress transcription of promoters that do not contain a canonical TATA sequence, while the Ccr4 and Caf1 proteins are required for non-fermentative gene expression.
Maillet, Laurent Jean Marie +4 more
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The CCR4–NOT Complex Plays Diverse Roles in mRNA Metabolism
2003It is increasingly clear that the synthesis of eukaryotic mRNA involves an integrated series of events involving large multisubunit protein complexes. The evolutionarily conserved CCR4-NOT complex of proteins has been found to be involved in several aspects of mRNA formation, including repression and activation of mRNA initiation, control of mRNA ...
Clyde L, Denis, Junji, Chen
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Novel interaction between CCR4 and CAF1 in rice CCR4–NOT deadenylase complex
Plant Molecular Biology, 2016Rice is an important crop in the world. However, little is known about rice mRNA deadenylation, which is an important regulation step of gene expression at the post-transcriptional level. The CCR4-NOT1 complex contains two key components, CCR4 and CAF1, which are the main cytoplasmic deadenylases in eukaryotic cells.
Wei-Lun, Chou +3 more
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RNA decay machines: Deadenylation by the Ccr4–Not and Pan2–Pan3 complexes
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013Shortening and removal of the 3' poly(A) tail of mature mRNA by poly(A)-specific 3' exonucleases (deadenylases) is the initial and often rate-limiting step in mRNA degradation. The majority of cytoplasmic deadenylase activity is associated with the Ccr4-Not and Pan2-Pan3 complexes.
Elmar, Wahle, G Sebastiaan, Winkler
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