Results 31 to 40 of about 34,412 (225)
PLoS Genetics, 2020 The Ccr4-Not complex functions as an effector of multiple signaling pathways that control gene transcription and mRNA turnover. Consequently, Ccr4-Not contributes to a diverse array of processes, which includes a significant role in cell metabolism.
Hongfeng Chen +3 more
doaj +1 more source
Role of Ccr4-Not complex in heterochromatin formation at meiotic genes and subtelomeres in fission yeast. [PDF]
, 2015 BACKGROUND: Heterochromatin is essential for chromosome segregation, gene silencing and genome integrity. The fission yeast Schizosaccharomyces pombe contains heterochromatin at centromeres, subtelomeres, and mating type genes, as well as at small ...
Bähler, Jürg +7 more
core +2 more sources
Architecture of the Nuclease Module of the Yeast Ccr4-Not Complex: the Not1-Caf1-Ccr4 Interaction [PDF]
Molecular Cell, 2012 Shortening eukaryotic poly(A) tails represses mRNA translation and induces mRNA turnover. The major cytoplasmic deadenylase, the Ccr4-Not complex, is a conserved multisubunit assembly. Ccr4-Not is organized around Not1, a large scaffold protein that recruits two 3'-5' exoribonucleases, Caf1 and Ccr4.
Jérôme Basquin +5 more
openaire +3 more sources
Building on the Ccr4‐Not architecture
BioEssays, 2016 In a recent issue of Nature Communications Ukleja and co‐workers reported a cryo‐EM 3D reconstruction of the Ccr4‐Not complex from Schizosaccharomyces pombe with an immunolocalization of the different subunits. The newly gained architectural knowledge provides cues to apprehend the functional diversity of this major eukaryotic regulator. Indeed, in the
Villanyi, Zoltan, Collart, Martine
openaire +4 more sources
The Ccr4-Not complex interacts with the mRNA export machinery. [PDF]
PLoS ONE, 2011 The Ccr4-Not complex is a key eukaryotic regulator of gene transcription and cytoplasmic mRNA degradation. Whether this complex also affects aspects of post-transcriptional gene regulation, such as mRNA export, remains largely unexplored.
Shana C Kerr +6 more
doaj +1 more source
Scientific Reports, 2022 Regulatory T-cells (Tregs) play a major role in suppressing anti-tumor immune responses. Mogamulizumab, an anti-CC chemokine receptor type 4 (CCR4) monoclonal antibody, depletes effector Tregs (eTregs). However, the clinical efficacy of mogamulizumab was
Shoya Ono +13 more
doaj +1 more source
CCR8 leads to eosinophil migration and regulates neutrophil migration in murine allergic enteritis [PDF]
, 2019 Allergic enteritis (AE) is a gastrointestinal form of food allergy. This study aimed to elucidate cellular and molecular mechanisms of AE using a murine model. To induce AE, BALB/c wild type (WT) mice received intraperitoneal sensitization with ovalbumin
Blanco Pérez, Frank +14 more
core +1 more source
A guide to chemokines and their receptors [PDF]
, 2018 The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G‐protein coupled heptahelical chemokine receptors.
Braun A +11 more
core +1 more source
Mathematical Model of HIV superinfection dynamics and R5 to X4 switch [PDF]
, 2006 During the HIV infection several quasispecies of the virus arise, which are able to use different coreceptors, in particular the CCR5 and CXCR4 coreceptors (R5 and X4 phenotypes, respectively).
Bagnoli, Franco +2 more
core +1 more source
eLife, 2020 Carbon catabolite repression 4 (CCR4) is a conserved mRNA deadenylase regulating posttranscriptional gene expression. However, regulation of CCR4 in virus infections is less understood.
Zhen-Jia Zhang +13 more
doaj +1 more source