Antigen‐presenting cell exosomes are protected from complement‐mediated lysis by expression of CD55 and CD59 [PDF]
European Journal of Immunology, 2003 AbstractExosomes are secreted nanometer‐sized vesicles derived from antigen‐presenting cells, which have attracted recent interest as they likely play important roles in immune regulation, and their use as cell‐free tools for immunotherapy has been proposed.
Aled, Clayton +4 more
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Optimizing complement-activating antibody-based cancer immunotherapy: a feasible strategy?
Journal of Translational Medicine, 2004 Passive immunotherapy with monoclonal antibodies (mAb) targeted to specific tumor-associated antigens is amongst the most rapidly expanding approaches to biological therapy of cancer.
Maio Michele +2 more
doaj +1 more source
Advances in the design and development of oncolytic measles viruses. [PDF]
, 2015 A successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding tissue. Oncolytic measles virus (MV) is one such virus that exhibits this characteristic and thus has
Hutzen, Brian +2 more
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An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA. [PDF]
, 2015 Antibody-mediated rejection (AMR) of solid organ transplants (SOT) is characterized by damage triggered by donor-specific antibodies (DSA) binding donor Class I and II HLA (HLA-I and HLA-II) expressed on endothelial cells.
Fishbein, MC +7 more
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Alternative Pathway Dysregulation and the Conundrum of Complement Activation by IgG4 Immune Complexes in Membranous Nephropathy [PDF]
, 2016 Membranous nephropathy (MN), a major cause of nephrotic syndrome, is a non-inflammatory immune kidney disease mediated by IgG antibodies that form glomerular subepithelial immune complexes.
Dorin-Bogdan Borza
core +13 more sources
Frontiers in Physiology, 2016 Human Gingival Mesenchymal Stem Cells (hGMSC) are multipotential cells that can expand and differentiate in culture under specific and standardized conditions.
Rosaliana Libro +9 more
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Preferential association of hepatitis C virus with CD19+ B cells is mediated by complement system [PDF]
, 2016 Extrahepatic disease manifestations are common in chronic hepatitis C virus (HCV) infection. The mechanism of HCV-related lymphoproliferative disorders is not fully understood.
Alter, Harvey J. +7 more
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SOLUBLE CD59-ANTIGEN LEVELS ARE INCREASED IN RENAL DISEASE PLASMA [PDF]
American Journal of Biochemistry and Biotechnology, 2013 Cluster of Differentiation antigen 59 (CD59) is a g lycosyl phosphatidylinositol-linked protein that pr otects cells from damage by lytic terminal complexes of co mplement. Soluble forms of CD59 in serum have been little investigated in disease states. In the prese nt study, by using a sandwich ELISA, reactivities w ith antibodies to CD59 were compared
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A strategy to ensure safety of stem cell-derived retinal pigment epithelium cells [PDF]
, 2016 Cell replacement and regenerative therapy using embryonic stem cell-derived material holds promise for the treatment of several pathologies. However, the safety of this approach is of prime importance given the teratogenic potential of residual stem ...
Choudhary, P, Whiting, PJ
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Expression of the glycosylphosphatidylinositol-linked complement-inhibiting protein CD59 antigen in insect cells using a baculovirus vector [PDF]
Biochemical Journal, 1993 CD59 antigen (CD59) is a glycosylphosphatidylinositol (GPI)-linked membrane glycoprotein which protects human cells from complement-mediated lysis. Here we report the expression of functionally active CD59 in Spodoptera frugiperda insect cells using a baculovirus vector.
A, Davies, B P, Morgan
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