Results 21 to 30 of about 6,754 (182)
An ultra scale-down analysis of the recovery by dead-end centrifugation of human cells for therapy. [PDF]
, 2014 An ultra scale-down method is described to determine the response of cells to recovery by dead-end (batch) centrifugation under commercially defined manufacturing conditions.
Delahaye, M +3 more
core +1 more source
Isolation and characterization of the complement-inhibiting protein CD59 antigen from platelet membranes [PDF]
Biochemical Journal, 1992 Several groups have recently described the isolation of a 20 kDa membrane-attack-complex (MAC)-inhibiting protein, termed ‘CD59 antigen’, from human erythrocyte membranes. Antibodies raised against erythrocyte CD59 antigen detect antigen on the surface of many other cell types, and in some of these cells the antigen has been shown to have a molecular ...
openaire +2 more sources
CD59 Blockade Enhances Antigen-Specific CD4+ T Cell Responses in Humans: A New Target for Cancer Immunotherapy? [PDF]
The Journal of Immunology, 2009 Abstract CD59, a broadly expressed GPI-anchored molecule, regulates formation of the membrane attack complex of the complement cascade. We previously demonstrated that mouse CD59 also down-modulates CD4+ T cell activity in vivo. In this study, we explored the role of CD59 on human CD4+ T cells.
Baalasubramanian, Sivasankar +6 more
openaire +2 more sources
The International Journal of Biological Markers, 2013 In colorectal cancer, CD133 + cells from fresh biopsies proved to be more tumorigenic than their CD133 – counterparts. Nevertheless, the function of CD133 protein in tumorigenic cells seems only marginal.
Marica Gemei +3 more
doaj +1 more source
The HPB-AML-I cell line possesses the properties of mesenchymal stem cells
Journal of Experimental & Clinical Cancer Research, 2010 Background In spite of its establishment from the peripheral blood of a case with acute myeloid leukemia (AML)-M1, HPB-AML-I shows plastic adherence with spindle-like morphology.
Tatsumi Eiji +9 more
doaj +1 more source
Analysis of PI (phosphatidylinositol)‐anchoring antigens in a patient of paroxysmal nocturnal hemoglobinuria (PNH) reveals deficiency of 1F5 antigen (CD59), a new complement‐regulatory factor [PDF]
FEBS Letters, 1990 FACS analysis together with PIPLC treatment was applied to Pi‐anchoring antigens such as DAF (decay‐accerelating factor, CD55), 1F5 antigen (CD59), CD14 and CD16 on the cell surfaces of blood cells from a normal adult and a male patient with paroxysmal nocturnal hemoglubinuria (PNH).
Taguchi, Ryo +3 more
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Journal of Fluorescence, 2023 Cluster of differentiation (CD59), a cell surface glycoprotein, regulates the complement system to prevent immune damage. In cancer, altered CD59 expression allows tumors to evade immune surveillance, promote growth, and resist certain immunotherapies.
Rahul Shankar, Tade +2 more
openaire +4 more sources
Stem Cell Research & Therapy, 2018 Background Mesenchymal stromal cells (MSC) are a heterogeneous population of multipotent progenitors used in the clinic because of their immunomodulatory properties and their ability to differentiate into multiple mesodermal lineages.
Eliana Amati +8 more
doaj +1 more source
Cloning and expression of porcine β1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen [PDF]
, 2014 Xenograft rejection of pigs organs with an engineered mutation in the GGTA-1 gene (GTKO) remains a predominantly antibody mediated process which is directed to a variety of non-Gal protein and carbohydrate antigens.
Byrne, GW +4 more
core +2 more sources
Frontiers in Immunology, 2019 Adipose mesenchymal stem cells (ASC) are considered minimally immunogenic. This is due to the low expression of human leukocyte antigens I (HLA-I), lack of HLA-II expression and low expression of co-stimulatory molecules such as CD40 and CD80.
Alvaro Avivar-Valderas +14 more
doaj +1 more source