Nature Immunology, 2022 CD28 and CTLA-4 (CD152) play essential roles in regulating T cell immunity, balancing the activation and inhibition of T cell responses, respectively.
A. Kennedy +20 more
semanticscholar +4 more sources
Increased CD86 but Not CD80 and PD-L1 Expression on Liver CD68+ Cells during Chronic HBV Infection. [PDF]
PLoS ONE, 2016 The failure to establish potent anti-HBV T cell responses suggests the absence of an effective innate immune activation. Kupffer cells and liver-infiltrating monocytes/macrophages have an essential role in establishing anti-HBV responses.
Elias A Said +9 more
doaj +2 more sources
Frontiers in Immunology, 2018 In the chronic phase of Chagas disease, 60% of the patients develop the asymptomatic form known as indeterminate (IND). The remaining 30% of the patients develop a life-threatening form in which digestive and/or cardiac (CARD) alterations take place. The
Bruna F. Pinto +13 more
doaj +2 more sources
CD86 costimulation enhances the antitumor activity of NKG2D CAR-Macrophages and synergizes with Anti-PD-L1 therapy to suppress prostate cancer progression [PDF]
Cell Communication and SignalingProstate cancer remains one of the most prevalent solid tumors in men worldwide and poses a major therapeutic challenge due to its immunologically “cold” tumor microenvironment (TME), which is characterized by low T cell infiltration, limited antigen ...
Abdulrahman Ibrahim +11 more
doaj +2 more sources
Talaromyces marneffei Can Capture CD86 Proteins of Macrophages in vitro
Infection and Drug Resistance, 2022 Jinling Fang,* Rifeng Chen,* Donghua Liu* Department of Dermatology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, People’s Republic of China*These authors contributed equally to this workCorrespondence ...
Fang J, Chen R, Liu D
doaj +3 more sources
CD86-based analysis enables observation of bona fide hematopoietic responses. [PDF]
Blood, 2020 -Sca-1+c-Kit+ cells; LSKs), is not suitable for the analysis of hematopoietic responses under biological stresses with interferon (IFN) production. Lin-Sca-1-c-Kit+ cells (LKs), downstream progenitors of LSKs, acquire Sca-1 expression upon inflammation ...
M. Kanayama +8 more
semanticscholar +3 more sources
CD86 is linked to apoptosis in canine histiocytic sarcoma
Frontiers in Veterinary ScienceImmune checkpoints are critical for the regulation of tumor growth and regression. Recently an effect of CD80 and CD86 on tumor regression in canine cutaneous histiocytoma has been described.
Benjamin Diehl +2 more
doaj +3 more sources
Late engagement of CD86 after influenza virus clearance promotes recovery in a FoxP3+ regulatory T cell dependent manner. [PDF]
PLoS Pathogens, 2014 Influenza A virus (IAV) infection in the respiratory tract triggers robust innate and adaptive immune responses, resulting in both virus clearance and lung inflammation and injury.
Emily K Moser +2 more
doaj +2 more sources
Amelioration of renal injury by Qihuang Jianpi Zishen Granules in lupus mice is correlated with AMPK/ULK1-dependent modulation of macrophage polarisation [PDF]
Lupus Science and MedicineObjective To investigate the effects of Qihuang Jianpi Zishen Granules (QJZG) on renal injury in SLE mice, focusing on macrophage M1/M2 polarisation mediated by the AMPK/ULK1 signalling pathway.Methods Parameters of renal function and proteinuria were ...
Ming Li +5 more
doaj +2 more sources
Skin TLR7 triggering promotes accumulation of respiratory dendritic cells and natural killer cells. [PDF]
, 2012 The TLR7 agonist imiquimod has been used successfully as adjuvant for skin treatment of virus-associated warts and basal cell carcinoma. The effects of skin TLR7 triggering on respiratory leukocyte populations are unknown.
Baal, Nelli +9 more
core +23 more sources