Results 21 to 30 of about 124,972 (317)

Expression of pro-inflammatory and co-stimulatory molecules on the surface of macrophages in vitro in patients with pulmonary tuberculosis

Бюллетень сибирской медицины, 2021
The aim of this study was to identify features of the expression of pro-inflammatory and co-stimulatory molecules on the surface of macrophages in vitro in patients with pulmonary tuberculosis, depending on the clinical form of the disease and ...
E. G. Churina, A. V. Sitnikova, O. I. Urazova, V. V. Novitskiy, M. R. Patysheva, P. N. Golubchikov, E. P. Stepanova   +6 more
doaj   +1 more source

Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Immunosuppressive Tregs constitutively express CTLA-4, an immune checkpoint receptor. Addressing the role of CTLA-4 in Treg-suppressive function, we show that Treg-expressed CTLA-4, even in the absence of its cytoplasmic portion, promoted ...
Murat Tekguc, J. Wing, Motonao Osaki, Jia Long, S. Sakaguchi   +4 more
semanticscholar   +1 more source

CD86 Is Associated with Immune Infiltration and Immunotherapy Signatures in AML and Promotes Its Progression

Journal of Oncology, 2023
Background Cluster of differentiation 86 (CD86), also known as B7-2, is a molecule expressed on antigen-presenting cells that provides the costimulatory signals required for T cell activation and survival.
Qianqian Zhang, Ruixue Ma, Huimin Chen, Wen-juan Guo, Zhenyu Li, K. Xu, Wei Chen   +6 more
semanticscholar   +1 more source

A Distinct Microglial Cell Population Expressing Both CD86 and CD206 Constitutes a Dominant Type and Executes Phagocytosis in Two Mouse Models of Retinal Degeneration

International Journal of Molecular Sciences, 2023
Microglial cells are the key regulators of inflammation during retinal degeneration (RD) and are conventionally classified as M1 or M2. However, whether the M1/M2 classification exactly reflects the functional classification of microglial cells in the ...
Yan Zhang, Y. Park, In-Beom Kim
semanticscholar   +1 more source

Immuno-phenotyping of IDH-mutant grade 3 astrocytoma and IDH-wildtype glioblastoma reveals specific differences in cells of myeloid origin

OncoImmunology, 2021
Gliomas are heavily infiltrated with immune cells of myeloid origin. Past studies have shown that high-grade gliomas have a higher proportion of alternatively activated and suppressive myeloid cells when compared to low-grade gliomas, which correlate ...
Jayashree V. Raghavan, Raksha A. Ganesh, Pranali Sonpatki, Divya Naik, Arivusudar Everad John, Priyanka Arunachalam, Darshat Shah, Hari P. S., Akhila Lakshmikantha, Shibu Pillai, Komal Prasad Chandrachari, Kiran Mariswamappa, Sathyanarayana Lale, Nameeta Shah, Siddharth Jhunjhunwala   +14 more
doaj   +1 more source

CD86+ Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses

Cancer immunology research, 2021
B cells are shown to be present in multiple cancer types and could be potential immunotherapeutic targets. These cells localize to tertiary lymphoid structures in the tumor microenvironment and through antigen presentation induce antigen-specific T-cell ...
K. Wennhold, M. Thelen, J. Lehmann, S. Schran, E. Preugszat, M. Garcia-Marquez, A. Lechner, A. Shimabukuro-Vornhagen, M. Ercanoglu, F. Klein, F. Thangarajah, S. Eidt, H. Löser, C. Bruns, A. Quaas, M. V. von Bergwelt-Baildon, H. Schlößer   +16 more
semanticscholar   +1 more source

Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86

Nature Communications, 2022
The MARCH E3 ubiquitin (Ub) ligase MARCH1 regulates trafficking of major histocompatibility complex class II (MHC II) and CD86, molecules of critical importance to immunity.
Haiyin Liu, Kayla R. Wilson, Ashley M Firth, C. Macri, P. Schriek, Annabelle B. Blum, Javiera Villar, Sam Wormald, Mitch Shambrook, Bangyan Xu, H. Lim, Hamish E. G. McWilliam, A. Hill, L. Edgington-Mitchell, I. Caminschi, M. Lahoud, É. Segura, M. Herold, J. Villadangos, J. Mintern   +19 more
semanticscholar   +1 more source

Prohibitins and the Cytoplasmic Domain of CD86 Cooperate To Mediate CD86 Signaling in B Lymphocytes [PDF]

The Journal of Immunology, 2013
Abstract CD86 engagement on a CD40L/IL-4–primed murine B cell activates signaling intermediates that promote NF-κB activation to increase Oct-2 and mature IgG1 mRNA and protein expression, as well as the rate of IgG1 transcription, without affecting class switch recombination.
Christopher R, Lucas, Hector M, Cordero-Nieves, Robert S, Erbe, Jaclyn W, McAlees, Sumeena, Bhatia, Richard J, Hodes, Kerry S, Campbell, Virginia M, Sanders   +7 more
openaire   +3 more sources

CD80/CD86 Costimulation Regulates Acute Vascular Rejection [PDF]

The Journal of Immunology, 2005
Abstract Xenotransplantation may provide the only solution to the shortage of human donor organs. Although hyperacute rejection associated with xenotransplantation can now be overcome, acute vascular rejection (AVR) remains a primary barrier to xenotransplantation.
Karoline A, Hosiawa, Hao, Wang, Mark E, DeVries, Bertha, Garcia, Weihua, Liu, Dejun, Zhou, Ali, Akram, Jifu, Jiang, Hongtao, Sun, Mark J, Cameron, Robert, Zhong, David J, Kelvin   +11 more
openaire   +2 more sources

CTLA-4 and PD-1 ligand gene expression in epithelial thyroid cancers [PDF]

, 2018
The dysregulation of PD-1 ligands (PD-L1 and PD-L2) and CTLA-4 ligands (CD80 and CD86) represents a tumor strategy to escape the immune surveillance. Here, the expression of PD-L1, PD-L2, CD80 and CD86 was evaluated at mRNA level in 94 patients affected ...
Antonelli, Alessandro, Arcieri, Stefano, Baldini, Enke, Barollo, Susi, Carbotta, Giovanni, Catania, Antonio, Fallahi, Poupak, Mian, Caterina, Monti, Massimo, Palmieri, Andrea, Pironi, Daniele, Sorrenti, Salvatore, Tartaglia, Francesco, Tuccilli, Chiara, Ulisse, Salvatore, Vergine, Massimo   +15 more
core   +3 more sources