Results 41 to 50 of about 124,972 (317)

Improved induction of anti-melanoma T cells by adenovirus-5/3 fiber modification to target human DCs [PDF]

, 2018
To mount a strong anti-tumor immune response, non T cell inflamed (cold) tumors may require combination treatment encompassing vaccine strategies preceding checkpoint inhibition.
Chondronasiou, Dafni, Curiel, David T, de Gruijl, Tanja D, Dmitriev, Igor, Eisden, Tracy-Jane T. H. D, Hooijberg, Erik, Icyuz, Mert, Matthews, Qiana L, Stam, Anita G.M, van de Ven, Rieneke   +9 more
core   +3 more sources

Exposure to the antimicrobial peptide LL-37 produces dendritic cells optimized for immunotherapy

OncoImmunology, 2019
Immunization of patients with autologous, ex vivo matured dendritic cell (DC) preparations, in order to prime antitumor T-cell responses, is the focus of intense research.
Emily Gwyer Findlay, Andrew J. Currie, Ailiang Zhang, Jana Ovciarikova, Lisa Young, Holly Stevens, Brian J. McHugh, Marta Canel, Mohini Gray, Simon W.F. Milling, John D.M. Campbell, John Savill, Alan Serrels, Donald J. Davidson   +13 more
doaj   +1 more source

Proteoglycan-4 is an essential regulator of synovial macrophage polarization and inflammatory macrophage joint infiltration

Arthritis Research & Therapy, 2021
Background Synovial macrophages perform a multitude of functions that include clearance of cell debris and foreign bodies, tissue immune surveillance, and resolution of inflammation.
Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Tannin A. Schmidt, Jennifer Totonchy, Khaled A. Elsaid   +5 more
doaj   +1 more source

CD28 between tolerance and autoimmunity: The side effects of animal models [version 1; referees: 2 approved] [PDF]

, 2018
Regulation of immune responses is critical for ensuring pathogen clearance and for preventing reaction against self-antigens. Failure or breakdown of immunological tolerance results in autoimmunity.
A Aruffo, A Levine, A Paterson, A Schneider, B Salomon, C Brunstein, C Camperio, C Dendrou, C Lin, C Peterfy, D Franckaert, D Tyrsin, E Hui, E Mayer, F Lühder, G Burmester, G Freeman, G Suntharalingam, H Gmünder, H Ko, I McInnes, I Vogel, J Esensten, J Gross, J Kremer, J Vahl, K Haanstra, M Kishore, M Kunkl, M Tacke, M Vierboom, M Wagner, N Beyersdorf, N Dilek, N Ohkura, N Poirier, N Porciello, N Porciello, O Acuto, P Emery, P Linsley, P Martin, P Tabares, Q Zhang, R Westhovens, R Westhovens, R Zhang, R Zhang, R Zhang, S Bhela, S Khoury, S Weißmüller, S Yao, T Hünig, T Hünig, T Thauland, T Thaventhiran, X He   +57 more
core   +2 more sources

Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells [PDF]

, 2010
The aim of cancer vaccines is induction of tumor-specific cytotoxic T lymphocytes (CTLs) that can reduce the tumor mass. Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune ...
Gong, Jianlin, Hara, Eiichi, Homma, Sadamu, Koido, Shigeo, Namiki, Yoshihisa, Ohkusa, Toshifumi, Tajiri, Hisao   +6 more
core   +5 more sources

Ciprofloxacin promotes polarization of CD86+CD206− macrophages to suppress liver cancer

Oncology Report, 2020
Gut microbiota can promote tumor development by producing toxic metabolites and inhibiting the function of immune cells. Previous studies have demonstrated that gut microbiota can reach the liver through the circulation and promote the occurrence of ...
M. Fan, Sicheng Chen, Y. Weng, Xian Li, Yingjiu Jiang, Xiaowen Wang, Mengjun Bie, Liqin An, Meng-hao Zhang, Bin Chen, Gaigai Huang, Jinghong Wu, Mengying Zhu, Q. Shi   +13 more
semanticscholar   +1 more source

Distinct agonist regulation of muscarinic acetylcholine M2-M3 heteromers and their corresponding homomers [PDF]

, 2015
Each subtype of the muscarinic receptor family of G protein-coupled receptors is activated by similar concentrations of the neurotransmitter acetylcholine or closely related synthetic analogs such as carbachol. However, pharmacological selectivity can be
Alvarez-Curto, Elisa, Aslanoglou, Despoina, Marsango, Sara, Milligan, Graeme   +3 more
core   +1 more source

Supplementary figure 1. CD68+CD86-/low M0-macrophage and CD68+CD86+ M1-macrophage phenotypes.

, 2022
Representative flow cytometry gating of live cells for the M0 macrophages (negative ctrl) in (A) as well as forward (FSC) and side scatter (SSC) intensity plots to gating Singlet in (B) and morphological analysis in (C). Evaluation of M0 (left) and M1 (right) cell phenotypes (D-G) was determined by flow cytometry as percentage for the expression of the
Gori, Manuele, Giannitelli, Sara Maria, Vadalà, Gianluca, Papalia, Rocco, Zollo, Loredana, Sanchez, Massimo, Trombetta, Marcella, Rainer, Alberto, Di Pino, Giovanni, Denaro, Vincenzo   +9 more
openaire   +1 more source

TRAM deletion attenuates monocyte exhaustion and alleviates sepsis severity

Frontiers in Immunology, 2023
Monocyte exhaustion characterized by immune-suppressive features can develop during sepsis and contribute to adverse patient outcomes. However, molecular mechanisms responsible for the establishment of immune-suppressive monocytes with reduced expression
Jing Wang, Yajun Wu, RuiCi Lin, Yao Zhang, Liwu Li   +4 more
doaj   +1 more source

In Vivo Imaging of Local Inflammation: Monitoring LPS-Induced CD80/CD86 Upregulation by PET

Molecular Imaging and Biology, 2020
The co-stimulatory molecules CD80 and CD86 are upregulated on activated antigen-presenting cells (APC). We investigated whether local APC activation, induced by subcutaneous (s.c.) inoculation of lipopolysaccharides (LPS), can be imaged by positron ...
M. Taddio, Claudia A. Castro Jaramillo, Peter Runge, A. Blanc, C. Keller, Z. Talip, M. Béhé, N. P. van der Meulen, C. Halin, R. Schibli, S. Krämer   +10 more
semanticscholar   +1 more source