Results 51 to 60 of about 72,520 (322)

Systematic Pan-Cancer Analysis Identifies CDK1 as an Immunological and Prognostic Biomarker

Journal of Oncology, 2022
Cyclin-dependent kinase 1 (CDK1) plays an important role in cancer development, progression, and the overall process of tumorigenesis. However, no pan-cancer analysis has been reported for CDK1, and the predictive role of CDK1 in immune checkpoint ...
Yaqi Yang, Qin Liu, Xiyuan Guo, Qing Yuan, Siji Nian, Peng-peng Kang, Zixi Xu, Lin Li, Y. Ye   +8 more
semanticscholar   +1 more source

Cyclin A and Cks1 promote kinase consensus switching to non-proline directed CDK1 phosphorylation

bioRxiv, 2022
Ordered protein phosphorylation by CDKs is a key mechanism for regulating the cell cycle. How temporal order is enforced in mammalian cells remains unclear.
Aymen Al-Rawi, S. Korolchuk, J. Endicott, T. Ly   +3 more
semanticscholar   +1 more source

Biological functions of CDK5 and potential CDK5 targeted clinical treatments. [PDF]

, 2017
Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are traditionally activated upon association with a regulatory subunit.
Casimiro, Mathew C., Pestell, Richard G., Shupp, Alison   +2 more
core   +2 more sources

CDK1 phosphorylates WRN at collapsed replication forks [PDF]

Nature Communications, 2016
Abstract Regulation of end-processing is critical for accurate repair and to switch between homologous recombination (HR) and non-homologous end joining (NHEJ). End resection is a two-stage process but very little is known about regulation of the long-range resection, especially in humans.
Valentina Palermo, Sara Rinalducci, Massimo Sanchez, Francesca Grillini, Joshua A. Sommers, Robert M. Brosh, Lello Zolla, Annapaola Franchitto, Pietro Pichierri   +8 more
openaire   +3 more sources

CDK1, CCNB1, and CCNB2 are Prognostic Biomarkers and Correlated with Immune Infiltration in Hepatocellular Carcinoma

Medical Science Monitor, 2020
Background Orderly G2/M transition in the cell cycle is controlled by the cyclin-dependent kinase 1/cyclin B (CDK1/CCNB) complex. We aimed to comprehensively investigate the roles of CDK1, CCNB1, and CCNB2 via multi-omics analysis and their relationships
Yiping Zou, Shiye Ruan, Liang Jin, Zhihong Chen, Hongwei Han, Yuanpeng Zhang, Z. Jian, Ye Lin, N. Shi, Haosheng Jin   +9 more
semanticscholar   +1 more source

lncRNA SNHG4 modulates colorectal cancer cell cycle and cell proliferation through regulating miR-590-3p/CDK1 axis

Aging, 2021
Colorectal cancer (CRC) is a prevalent malignancy worldwide. The development of genome sequencing technology has allowed the discovery that epigenetic regulation might play a critical role in CRC tumorigenesis.
Zhongyi Zhou, Fengbo Tan, Q. Pei, Chenglong Li, Yuanquan Zhou, Yuqiang Li, Haiping Pei   +6 more
semanticscholar   +1 more source

Dissection of Cdk1–cyclin complexes in vivo [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance A simple strategy is described to discover cyclin dependency of general cell cycle regulatory kinase cyclin-dependent kinase 1 for substrates in vivo. γ-Tubulin is discovered to be a specific B cyclin Clb3–cyclin-dependent kinase 1 substrate.
Po Hien, Ear, Michael J, Booth, Diala, Abd-Rabbo, Jacqueline, Kowarzyk Moreno, Conrad, Hall, Daici, Chen, Jackie, Vogel, Stephen W, Michnick   +7 more
openaire   +2 more sources

Phosphorylation of eIF4GII and 4E-BP1 in response to nocodazole treatment: a reappraisal of translation initiation during mitosis [PDF]

, 2013
Translation mechanisms at different stages of the cell cycle have been studied for many years, resulting in the dogma that translation rates are slowed during mitosis, with cap-independent translation mechanisms favored to give expression of key ...
Abbie Mead, Bonneau, Bradley, Bushell, Byrd, Carmena, Clemens, Coldwell, Coldwell, Coldwell, Dobrikov, Elia, Fadden, Fan, Franz-Wachtel, Gingras, Gingras, Gradi, Harrison, Heesom, Heesom, Hinton, Jackson, Jang, Joanne Cowan, Kim, Laplante, Lisa Perry, Ma, Margalit, Marissen, Mark Coldwell, Mark Willett, Markete Vlasak, Morley, Morris, Nagano, Pasquier, Perez, Proud, Pyronnet, Pyronnet, Qin, Qin, Shevchenko, Simon Morley, Singh, Skop, Smith, Sonenberg, Tinton, Vassilev, Wek, Whitfield, Wurzenberger, Xue   +55 more
core   +1 more source

Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis

Cell Discovery, 2020
The cyclic GMP-AMP synthase (cGAS) is a widely used DNA sensor, which detects cytosolic DNA species without a preference of self or non-self microbial DNA in interphase to initiate innate immune response.
Li Zhong, Ming-Ming Hu, Li-Jun Bian, Y. Liu, Qiang Chen, H. Shu   +5 more
semanticscholar   +1 more source

Phosphorylation of MCPH1 isoforms during mitosis followed by isoform‐specific degradation by APC/C‐CDH1 [PDF]

, 2019
Microcephalin‐1 (MCPH1) exists as 2 isoforms that regulate cyclin‐dependent kinase‐1 activation and chromosome condensation during mitosis, with MCPH1 mutations causing primary microcephaly.
Blain, Peter G., Dunn, Michael, Jowsey, Paul, Meyer, Stephanie K., Porter, Andrew, Vidier, Daniel S.   +5 more
core   +2 more sources