Results 51 to 60 of about 35,931 (261)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Polarized Cell Growth: Double Grip by CDK1 [PDF]

Current Biology, 2007
Precise coupling of cell growth and cell-cycle progression is crucial for achieving cell homeostasis. A recent study sheds light on two distinct roles of cyclin-dependent kinase 1 (CDK1) in promoting polarized cell growth in budding yeast.
Giulia Rancati, Rong Li
openaire   +3 more sources

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Inhibition of CDK1 Reverses the Resistance of 5-Fu in Colorectal Cancer

Cancer Management and Research, 2020
Yiping Zhu,1 Kai Li,2 Jieling Zhang,2 Lu Wang,1 Lili Sheng,1 Liang Yan2 1Department of Oncology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, People’s Republic of China; 2Provincial Key Laboratory of Biological Macro ...
Zhu Y, Li K, Zhang J, Wang L, Sheng L, Yan L   +5 more
doaj  

Design, Synthesis, and Activity Assays of Cyclin-Dependent Kinase 1 Inhibitors With Flavone Scaffolds

Frontiers in Chemistry, 2022
Cyclin-dependent kinase 1 (CDK1) plays an indispensable role in the whole cell cycle. It has become a new target for cancer therapy. According to the binding mode of a pan-CDK inhibitor, flavopiridol with CDK1, and our previous work, a new series of ...
Lanlan Fu, Jiajia Mou, Yanru Deng, Xiaoliang Ren, Shuang Qiu   +4 more
doaj   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source

Cdk1-Dependent Regulation of the Mitotic Inhibitor Wee1 [PDF]

Cell, 2005
The Wee1 kinase phosphorylates and inhibits cyclin-dependent kinase 1 (Cdk1), thereby delaying entry into mitosis until appropriate conditions have been met. An understanding of the mechanisms that regulate Wee1 should provide new insight into how cells make the decision to enter mitosis.
Steven P. Gygi, Douglas R. Kellogg, Stacy L. Harvey, Alyson Charlet, Wilhelm Haas   +4 more
openaire   +3 more sources

Decoding Chemo‐Mechanical Failure Mechanisms of Solid‐State Lithium Metal Battery Under Low Stack Pressure via Optical Fiber Sensors

Advanced Materials, EarlyView.
By FBG sensing the Li/electrolyte interfacial stress in solid‐state battery, the Li metal anode failure reasons as dendrite‐induced uneven stress distribution at electrode/electrolyte interface are disclosed. A Li–Sn composite anode is demonstrated effective in stabilizing the interface mechanics and the solid‐state full cell performance at low stack ...
Guocheng Li, Taolue Zhang, Jiayue Tang, Mingtao Liu, Yizhan Xie, Jingya Yu, Xiaobin Hui, Canbin Deng, Xibin Lu, Yoonseob Kim, Jiaqiang Huang, Zheng‐Long Xu   +11 more
wiley   +1 more source