Results 1 to 10 of about 471,310 (334)
Matrix stiffness affects endocytic uptake of MK2-inhibitor peptides. [PDF]
PLoS ONE, 2014 In this study, the role of substrate stiffness on the endocytic uptake of a cell-penetrating peptide was investigated. The cell-penetrating peptide, an inhibitor of mitogen-activated protein kinase activated protein kinase II (MK2), enters a primary ...
Jamie L Brugnano, Alyssa Panitch
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Cell-Penetrating Peptide–Bismuth Bicycles
Angewandte Chemie, 2023 Cell-penetrating peptides (CPPs) play a significant role in the delivery of cargos into human cells for a wide range of therapeutic and diagnostic applications. We disclose the first CPPs based on peptide–bismuth bicycles, which can be readily obtained from commercially available peptide precursors, making them highly accessible for a wide range of ...
Saan Voss +8 more
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The C-terminal domain of Emi2 conjugated to cell-penetrating peptide activates mouse oocyte [PDF]
Frontiers in Cell and Developmental BiologyIntroductionThe cell cycle of ovulated oocytes from various animal species, including mice, arrests at the second meiotic metaphase until fertilization. The meiotic cell cycle must be initiated to initiate embryonic development.
Toru Suzuki, Toru Suzuki
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Curvature-Induced Membrane Remodeling by the Cell-Penetrating Peptide Pep-1 [PDF]
MembranesThe cell-penetrating peptide Pep-1 interacts with lipid membranes through combined electrostatic and hydrophobic forces, yet the structural details of its membrane remodeling activity remain unclear.
Yasith Indigahawela Gamage, Jianjun Pan
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Fusion Partner Facilitates Expression of Cell-Penetrating Peptide L2 in Pichia pastoris [PDF]
AntibioticsBackground: L2 is formed by combining the pheromone of Streptococcus agalactiae (S. agalactiae) and a cell-penetrating peptide (CPP) with cell-penetrating selectivity. L2 has more significant penetration and better specificity for killing S.
Xuan Li +8 more
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Cell Penetrating Peptides [PDF]
, 2022 Classes of Cell-Penetrating Peptides. Mechanisms of Cell Penetration, Interactions of Cell-Penetrating Peptides with Plasma Membranes and Lipid Models. Applications of Cell-Penetrating Peptides.
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Selective Moonlighting Cell-Penetrating Peptides [PDF]
Pharmaceutics, 2021 Cell penetrating peptides (CPPs) are molecules capable of passing through biological membranes. This capacity has been used to deliver impermeable molecules into cells, such as drugs and DNA probes, among others. However, the internalization of these peptides lacks specificity: CPPs internalize indistinctly on different cell types. Two major approaches
Rafael Morán-Torres +5 more
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Glycosylated Cell‐Penetrating Peptides (GCPPs) [PDF]
ChemBioChem, 2019 AbstractThe cell membrane regulates the exchange of molecules and information with the external environment. However, this control barrier hinders the delivery of exogenous bioactive molecules that can be applied to correct cellular malfunctions. Therefore, the traffic of macromolecules across the cell membrane represents a great challenge for the ...
Iván Gallego +8 more
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Cell-Penetrating Antimicrobial Peptides with Anti-Infective Activity against Intracellular Pathogens
Antibiotics, 2022 Cell-penetrating peptides (CPPs) are natural or engineered peptide sequences with the intrinsic ability to internalize into a diversity of cell types and simultaneously transport hydrophilic molecules and nanomaterials, of which the cellular uptake is ...
Gabriela Silva Cruz +3 more
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Bioactive Materials, 2022 Peptides have gained increasing interests as drug candidates in modern pharmaceutical industry, however, the development of peptide drugs acting on intracellular targets is limited due to their membrane impermeability.
Lanfang Ren, Yang Gao, Yiyun Cheng
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