Results 1 to 10 of about 371,071 (337)
The C-terminal domain of Emi2 conjugated to cell-penetrating peptide activates mouse oocyte. [PDF]
Front Cell Dev BiolIntroductionThe cell cycle of ovulated oocytes from various animal species, including mice, arrests at the second meiotic metaphase until fertilization. The meiotic cell cycle must be initiated to initiate embryonic development.
Suzuki T.
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Fusion Partner Facilitates Expression of Cell-Penetrating Peptide L2 in Pichia pastoris. [PDF]
Antibiotics (Basel)Background: L2 is formed by combining the pheromone of Streptococcus agalactiae (S. agalactiae) and a cell-penetrating peptide (CPP) with cell-penetrating selectivity. L2 has more significant penetration and better specificity for killing S.
Li X +8 more
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Curvature-Induced Membrane Remodeling by the Cell-Penetrating Peptide Pep-1. [PDF]
Membranes (Basel)The cell-penetrating peptide Pep-1 interacts with lipid membranes through combined electrostatic and hydrophobic forces, yet the structural details of its membrane remodeling activity remain unclear.
Gamage YI, Pan J.
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Veterinary Research, 2018 Cell-penetrating peptide (CPP) is a promising cargo for delivering bioactive molecules. In this study, the N terminus of VP1 from chicken anemia virus, designated as CVP1, was found to carry enriched arginine residues with α-helix.
Gaowei Hu +9 more
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Matrix stiffness affects endocytic uptake of MK2-inhibitor peptides. [PDF]
PLoS ONE, 2014 In this study, the role of substrate stiffness on the endocytic uptake of a cell-penetrating peptide was investigated. The cell-penetrating peptide, an inhibitor of mitogen-activated protein kinase activated protein kinase II (MK2), enters a primary ...
Jamie L Brugnano, Alyssa Panitch
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Cell-Penetrating Antimicrobial Peptides with Anti-Infective Activity against Intracellular Pathogens
Antibiotics, 2022 Cell-penetrating peptides (CPPs) are natural or engineered peptide sequences with the intrinsic ability to internalize into a diversity of cell types and simultaneously transport hydrophilic molecules and nanomaterials, of which the cellular uptake is ...
Gabriela Silva Cruz +3 more
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Bioactive Materials, 2022 Peptides have gained increasing interests as drug candidates in modern pharmaceutical industry, however, the development of peptide drugs acting on intracellular targets is limited due to their membrane impermeability.
Lanfang Ren, Yang Gao, Yiyun Cheng
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A cancer specific cell-penetrating peptide, BR2, for the efficient delivery of an scFv into cancer cells. [PDF]
PLoS ONE, 2013 Cell-penetrating peptides (CPPs) have proven very effective as intracellular delivery vehicles for various therapeutics. However, there are some concerns about non-specific penetration and cytotoxicity of CPPs for effective cancer treatments.
Ki Jung Lim +6 more
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Scientific Reports, 2022 Crossing the cellular membrane is one of the main barriers during drug discovery; many potential drugs are rejected for their inability to integrate into the intracell fluid.
Diego Muñoz-Gacitúa +2 more
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Pharmaceutics, 2023 Palbociclib (PBC) is an FDA-approved CDK4/6 inhibitor used for breast cancer treatment. PBC has been demonstrated its ability to suppress the proliferation of glioma cells by inducing cell cycle arrest. However, the efflux transporters on the blood-brain
Yu-Chen Lo, Wen-Jen Lin
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