Results 131 to 140 of about 11,198,861 (420)
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
eLife, 2019 The insect central complex (CX) is a conserved brain region containing 60 + neuronal subtypes, several of which contribute to navigation. It is not known how CX neuronal diversity is generated or how developmental origin of subtypes relates to function ...
Luis F Sullivan +2 more
doaj +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Cell lineage tracing using nuclease barcoding [PDF]
arXiv, 2016 Lineage tracing, the determination and mapping of progeny arising from single cells, is an important approach enabling the elucidation of mechanisms underlying diverse biological processes ranging from development to disease. We developed a dynamic sequence-based barcode for lineage tracing and have demonstrated its performance in C.
arxiv
Optimal Transport using GANs for Lineage Tracing [PDF]
arXiv, 2020 In this paper, we present Super-OT, a novel approach to computational lineage tracing that combines a supervised learning framework with optimal transport based on Generative Adversarial Networks (GANs). Unlike previous approaches to lineage tracing, Super-OT has the flexibility to integrate paired data.
arxiv
Origins of the avian neural crest: the role of neural plate-epidermal interactions [PDF]
, 1995 We have investigated the lineage and tissue interactions that result in avian neural crest cell formation from the ectoderm. Presumptive neural plate was grafted adjacent to non-neural ectoderm in whole embryo culture to examine the role of tissue ...
Bronner-Fraser, Marianne +1 more
core
Clonal analysis of lineage fate in native hematopoiesis
Nature, 2017 Haematopoiesis, the process of mature blood and immune cell production, is functionally organized as a hierarchy, with self-renewing haematopoietic stem cells and multipotent progenitor cells sitting at the very top. Multiple models have been proposed as
Alejo E. Rodriguez-Fraticelli +9 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
Cell lineage analysis of the avian neural crest [PDF]
, 1991 Neural crest cells migrate extensively and give rise to diverse cell types, including cells of the sensory and autonomic nervous systems. A major unanswered question concerning the neural crest is when and how the neural crest cells become determined to ...
Bronner-Fraser, Marianne +1 more
core
Inference of single-cell phylogenies from lineage tracing data using Cassiopeia. [PDF]
, 2020 The pairing of CRISPR/Cas9-based gene editing with massively parallel single-cell readouts now enables large-scale lineage tracing. However, the rapid growth in complexity of data from these assays has outpaced our ability to accurately infer ...
Chan, Michelle M +8 more
core +1 more source