Results 261 to 270 of about 11,198,861 (420)

MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis

open access: yesAdvanced Science, EarlyView.
MeCP2 lactylation protects against ischemic stroke by reducing brain infarct volume and improving neurological outcomes. Lactylation at K210/K249 exerts neuroprotective effects by repressing the transcription of apoptosis‐associated genes, including Pdcd4 and Pla2g6. HDAC3 and p300 serve as key regulatory enzymes for MeCP2 lactylation following stroke.
Min Sun   +13 more
wiley   +1 more source

Confined Migration Drives Stem Cell Differentiation

open access: yesAdvanced Science, EarlyView.
Human mesenchymal stem cell (hMSC) homing to sites of regeneration requires navigation through mechanically confining extracellular matrix environments, inducing rapid and dramatic morphological adaptation. By exposing hMSCs to specific levels of physiological confinement, it is demonstrated that confinement can induce osteogenesis, and that this fate ...
Xu Gao   +6 more
wiley   +1 more source

Cell lineage-resolved embryonic morphological map reveals signaling associated with cell fate and size asymmetry. [PDF]

open access: yesNat Commun
Guan G   +10 more
europepmc   +1 more source

Genomic and Cis‐Regulatory Basis of a Plastic C3‐C4 Photosynthesis in Eleocharis Baldwinii

open access: yesAdvanced Science, EarlyView.
The sedge Eleocharis baldwinii remarkably switches between C3‐like and C4‐like photosynthesis in response to environmental conditions. Combining gap‐free genome assembly with single‐cell multi‐omics, this study uncovers how subgenome dominance and cell‐specific cis‐regulation enable C4 photosynthesis.
Lu Chen   +11 more
wiley   +1 more source

A Factor Induced by Differentiation Signals in Cells of the Macrophage Lineage Binds to the Gamma Interferon Activation Site [PDF]

open access: green, 1994
Andreas Eilers   +5 more
openalex   +1 more source

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