Results 61 to 70 of about 729,910 (357)

Cell type composition and circuit organization of clonally related excitatory neurons in the juvenile mouse neocortex

eLife, 2020
Clones of excitatory neurons derived from a common progenitor have been proposed to serve as elementary information processing modules in the neocortex.
Cathryn R Cadwell, Federico Scala, Paul G Fahey, Dmitry Kobak, Shalaka Mulherkar, Fabian H Sinz, Stelios Papadopoulos, Zheng H Tan, Per Johnsson, Leonard Hartmanis, Shuang Li, Ronald J Cotton, Kimberley F Tolias, Rickard Sandberg, Philipp Berens, Xiaolong Jiang, Andreas Savas Tolias   +16 more
doaj   +1 more source

Advances in cell lineage reprogramming [PDF]

Science China Life Sciences, 2013
As a milestone breakthrough of stem cell and regenerative medicine in recent years, somatic cell reprogramming has opened up new applications of regenerative medicine by breaking through the ethical shackles of embryonic stem cells. However, induced pluripotent stem (iPS) cells are prepared with a complicated protocol that results in a low ...
Zhou, JunNian, Yue, Wen, Pei, XueTao
openaire   +2 more sources

Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin. [PDF]

, 2012
Expression of the cell-surface antigen CD10 has long been used to define the lymphoid commitment of human cells. Here we report a unique lymphoid-primed population in human bone marrow that was generated from hematopoietic stem cells (HSCs) before onset ...
Crooks, Gay M, Ge, Shundi, Hao, Qian-Lin, Kohn, Lisa A, Mikkola, Hanna KA, Parekh, Chintan, Sasidharan, Rajkumar, Zhu, Yuhua   +7 more
core   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Lineage tracing of mutant granulosa cells reveals in vivo protective mechanisms that prevent granulosa cell tumorigenesis [PDF]

, 2023
Shudong Niu, Kaixin Cheng, Longzhong Jia, Jing Liang, Lu Mu, Yibo Wang, Xuebing Yang, Yang Chen, Yan Zhang, Chao Wang, Lijun Huang, Huarong Wang, Shuang Zhang, Hua Zhang   +13 more
openalex   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Targeting senescent cells in aging and COVID-19: from cellular mechanisms to therapeutic opportunities

Cell Regeneration
The COVID-19 pandemic has caused a global health crisis and significant social economic burden. While most individuals experience mild or non-specific symptoms, elderly individuals are at a higher risk of developing severe symptoms and life-threatening ...
Yuan Yu, Kaixuan Lin, Haoyu Wu, Mingli Hu, Xuejie Yang, Jie Wang, Johannes Grillari, Jiekai Chen   +7 more
doaj   +1 more source

Initial characterization of gap phase introduction in every cell cycle of C. elegans embryogenesis

Frontiers in Cell and Developmental Biology, 2022
Early embryonic cell cycles usually alternate between S and M phases without any gap phase. When the gap phases are developmentally introduced in various cell types remains poorly defined especially during embryogenesis.
Ming-Kin Wong, Vincy Wing Sze Ho, Xiaotai Huang, Xiaotai Huang, Lu-Yan Chan, Dongying Xie, Runsheng Li, Xiaoliang Ren, Guoye Guan, Yiming Ma, Boyi Hu, Boyi Hu, Hong Yan, Zhongying Zhao, Zhongying Zhao   +14 more
doaj   +1 more source

Towards a digital model of zebrafish embryogenesis. Integration of Cell Tracking and Gene Expression Quantification [PDF]

, 2010
We elaborate on a general framework composed of a set of computational tools to accurately quantificate cellular position and gene expression levels throughout early zebrafish embryogenesis captured over a time-lapse series of in vivo 3D images.
Bourgine, Paul, Castro González, Carlos, Desnoulez, Sophie, Douloquin, Louise, Ledesma Carbayo, María Jesús, Luengo Oroz, Miguel Ángel, Melani, Camilo, Peyrieras, Nadine, Santos Lleo, Andres de, Savy, Thierry   +9 more
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source