Results 141 to 150 of about 4,109 (159)
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Phlorhizin Protects against Erythrocyte Cell Membrane Scrambling
Journal of Agricultural and Food Chemistry, 2011Phlorhizin interferes with glucose transport. Glucose depletion triggers suicidal erythrocyte death or eryptosis, characterized by cell shrinkage and cell membrane scrambling. Eryptosis is further triggered by oxidative stress. The present study explored whether phlorhizin influences eryptosis following glucose depletion or oxidative stress.
Sergios Gatidis +2 more
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Triggering of Erythrocyte Cell Membrane Scrambling by Salinomycin [PDF]
Basic and Clinical Pharmacology and Toxicology, 2014 AbstractSalinomycin, a polyether ionophore antibiotic effective against a variety of pathogens, has been shown to trigger apoptosis of cancer cells and cancer stem cells. The substance is thus considered for the treatment of malignancy. Salinomycin compromises tumour cell survival at least in part by interference with mitochondrial function ...
Rosi Bissinger +2 more
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Scrambling of Phospholipids Activates Red Cell Membrane Cholesterol [PDF]
Biochemistry, 2007 Cholesterol is predicted to associate more strongly with the outer than the inner leaflet of plasma membrane bilayers based on the relative in vitro affinities of their phospholipids. Complex formation with the high-affinity species (especially saturated sphingomyelins) is said to reduce the chemical activity (escape potential or fugacity) of the ...
Yvonne Lange, Theodore L Steck
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Triggering of Erythrocyte Cell Membrane Scrambling by Ursolic Acid
Journal of Natural Products, 2011Ursolic acid (1), a triterpenoid with pleotropic effects including inhibition of tumor growth, is well known to trigger apoptosis of nucleated cells. The effect is at least partially due to altered gene expression and mitochondrial dysfunction. Erythrocytes lack nuclei and mitochondria but, similar to nucleated cells, may undergo suicidal cell death or
Kashif Jilani +2 more
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Cellular and Molecular Biology Letters, 2014 AbstractThe styryl dye FM1-43 becomes highly fluorescent upon binding to cell membranes. The breakdown of membrane phospholipid asymmetry in ionophore-stimulated T-lymphocytes further increases this fluorescence [Zweifach, 2000]. In this study, the capacity of FM1-43 to monitor membrane phospholipid scrambling was explored using flow cytometry in human
Anna Wröbel +2 more
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Effect of osmotic shock and urea on phosphatidylserine scrambling in thrombocyte cell membranes
American Journal of Physiology-Cell Physiology, 2010Blood passing the renal medulla enters a strongly hypertonic environment challenging functional properties and survival of blood cells. In erythrocytes, exposure to hyperosmotic shock stimulates Ca 2+ entry and ceramide formation with subsequent cell membrane scrambling, an effect partially ...
Sergios, Gatidis +3 more
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Erythrocyte Shrinkage and Cell Membrane Scrambling after Exposure to the Ionophore Nonactin
Basic & Clinical Pharmacology & Toxicology, 2015AbstractThe ionophore antibiotic nonactin permeabilizes cell membranes to and K+. Treatment of erythrocytes with nonactin is expected to trigger cellular K+ loss with subsequent cell shrinkage, which in turn is known to trigger suicidal death of a wide variety of cells including erythrocytes.
Thomas, Peter +2 more
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Organelle intermixing and membrane scrambling in cell death.
Methods in enzymology, 2009In many cell types, intracellular organelles are involved along the progression of cell death. While many studies have focused on individual organelles such as mitochondria, evidence has accumulated that different organelles are simultaneously engaged in dynamic changes induced by death signaling before nuclear alterations are evident.
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TMEM16 scramblases thin the membrane to enable lipid scrambling
Nature Communications, 2022Maria E Falzone +2 more
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