Results 161 to 170 of about 5,974,193 (263)

Recent advances in TMEM16F: structural plasticity, functional versatility, and implications for human diseases. [PDF]

Cell Commun Signal
Chen L, Qian Z.
europepmc   +1 more source

Extreme deformability of insect cell membranes is governed by phospholipid scrambling

Extreme deformability of insect cell membranes is governed by phospholipid scrambling
Organization of dynamic cellular structure is crucial for a variety of cellular functions. In this study, we report that Drosophila and Aedes have highly elastic cell membranes with extremely low membrane tension and high resistance to mechanical stress.
openaire   +1 more source

Maternal Hyperglycemia Disrupts Cerebral Cortex Development Through the Foxp1‐Dll1‐Notch Axis

Advanced Science, EarlyView.
Maternal hyperglycemia disrupts offspring cortical development through a Foxp1–Dll1–Notch signaling axis. In a PGDM mouse model, intrauterine hyperglycemia decreases cortical thickness and perturbs neuronal layering by downregulating Foxp1, which transcriptionally regulates the Notch ligand Dll1.
Longkai He, Ya Jin, Guosheng Liu, Hao Liu, Xinyi Zhu, Weipeng Xu, Wei Li, Meiyao He, Yao Shen, Bingxiao Li, Xuesong Yang, Xiaoyu Wang, Shasha Han   +12 more
wiley   +1 more source

A TMEM63B variant with enhanced mechanosensitive channel activity and acquired lipid scramblase function. [PDF]

J Gen Physiol
Lowry AJ, Liang P, Gonzalez Torres MA, Yang H.   +3 more
europepmc   +1 more source

Therapeutic Peptide‐Programmed Liquid‐Crystalline Topology Switching for pH‐Gated Postoperative Cancer Immunotherapy

Advanced Science, EarlyView.
A VDAP‐programmed liquid‐crystalline depot enables pH‐responsive postoperative immunotherapy for triple‐negative breast cancer. VDAP stabilizes a leakage‐resistant HII mesophase through peptide–lipid electrostatic assembly, whereas tumor acidosis unlocks the matrix and promotes graded topology remodeling toward a bicontinuous Im3̄m cubic phase for ...
Yan Yan, Bin Chen, Yanqing Wang, Yuxi Hou, Zhenlin Ma, Zini Yang, Xia Yin, Yiling Chen, Litao Huang, Menghan Cai, Xinlin Liu, Yi Zhun Zhu, Li Ye   +12 more
wiley   +1 more source

Mechanism of lipid transfer by bridge-like protein VPS13A and the scramblase XK. [PDF]

Cell
Hu B, Álvarez D, Rocha-Roa C, Guyard V, Li D, Ahmed Y, Wang X, De Camilli P, Vanni S, Reinisch KM.   +9 more
europepmc   +1 more source

A Biomimetic PLK1 Nanodelivery System Promotes Migrasome‐Mediated Mitocytosis to Restore Efferocytosis and Functional Recovery After Spinal Cord Injury

Advanced Science, EarlyView.
MM‐NPs@PLK1 are formed by encapsulating PLK1 plasmids within CBP5 and coating the nanocomplexes with macrophage membranes. After macrophage‐associated uptake, the NPs@PLK1 enter the cytoplasm and release the PLK1‐encoding plasmid in response to elevated intracellular ROS levels.
Zhenxin Hu, Haoli Wang, Jing Huang, Junhua Zhou, Jialong Hou, Hanwei Miao, Huixin Tan, Yining Wang, Hao Hu, Na Li, Pengcheng Qiu, Hongyu Zhang, Da He, Qingqing Wang   +13 more
wiley   +1 more source

Sorting of lysosomal enzyme and autophagy are regulated by the GGA1-induced TGN lipid scrambling. [PDF]

Sci Adv
Takahashi K, Tomishige N, Abe M, Šolinc G, Rae J, Yamaji T, Przybilla F, Richert L, Humbert N, Uemura T, Wollert T, Waguri S, Hanada K, Sako Y, Anderluh G, Parton RG, Mély Y, Tomasetto C, Alpy F, Kobayashi T.   +19 more
europepmc   +1 more source

Donor‐Cell Senescence Redirects PINK1‐Marked Mitochondrial Cargo From Mitophagy to Microvesicle Transfer Through SUMO3‐Stabilized HSPA9

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicle therapies have been developed for tissue repair, but how donor‐cell senescence reshapes vesicle‐mediated mitochondrial transfer remains unclear. Here, we show that senescent adipose‐derived stem cells (ADSCs) redirect damaged mitochondria into microvesicles (MVs), converting protective vesicles into pro‐degenerative ...
Zixuan Ou, Mingke Zhao, Zhiwei Ling, Lianqi Peng, Bide Tong, Huaizhen Liang, Hongchuan Wang, Di Wu, Yifan Du, Zhi Du, Shihao Zhang, Yuyuan Jia, Yifan Qian, Gan Xu, Liuliang He, Gang Li, Shun Zhang, Lei Tan, Kun Wang, Xiaobo Feng, Cao Yang, Zhiwei Liao   +21 more
wiley   +1 more source

Mechanism-guided mutagenesis of Rft1 to test its role as a dolichol-linked oligosaccharide scramblase in cells. [PDF]

Protein Sci
Chiduza GN, Sakata KT, Wolfe HG, Noor F, Menon AK.   +4 more
europepmc   +1 more source