Results 191 to 200 of about 5,974,193 (263)

18F‐FGln PET/CT Imaging of Glutamine Uptake Has Potential for Predicting Immunotherapy Response in Hepatocellular Carcinoma

Advanced Science, EarlyView.
18F‐FGln PET/CT imaging serves as a marker of Gln uptake in hepatocellular carcinoma. Tumors with high Gln uptake drive Treg‐mediated immunosuppression and immune evasion during antitumor immunotherapy. Conversely, tumors with low Gln uptake maintain sufficient Gln in the TME, suppressing Tregs and enabling cytotoxic T cells to inhibit tumor growth ...
Yi Liu, Jindian Li, Xiaoyu Pan, Xiaoping Xu, Xuan Huang, Simin He, Jianping Zhang, Fei Liu, Shaoli Song   +8 more
wiley   +1 more source

CLCC1 governs ER bilayer equilibration to maintain lipid homeostasis. [PDF]

Nature
Wu L, Wang J, Wang Y, Yang J, Yao Y, Wang Y, Huang D, Hu Y, Xu X, Wang R, Du W, Shi Y, Li Q, Liu L, Zhu Y, Li S, Chen FJ, Zhang X, Wang X, Guo Q, Xu L, Li P, Chen XW.   +22 more
europepmc   +1 more source

Chloride Channels as Determinants of Anti-Cancer Drug Response: Why the Therapeutic Direction Reverses Between Channels and Between Tissues. [PDF]

Cancers (Basel)
Seo Y.
europepmc   +1 more source

Opsins are phospholipid scramblases in all domains of life. [PDF]

mBio
Maschmann ZA, Hardy DE, Menon I, Webb J, Menon AK, Forest KT.   +5 more
europepmc   +1 more source

Lipid asymmetry disruption by XKR8 orchestrates neutrophil extracellular trap formation and inhibits fungal infection. [PDF]

Nat Immunol
Liu W, Ping J, Deng L, Wang K, Xu J, Peng N, Yang M, Tang H, Liu Z, Wang W, Li T, Xie J, Han Y, Dong Z, Hu W, Liu Z, Wu N.   +16 more
europepmc   +1 more source

Quantification of lipid sorting during clathrin-mediated endocytosis. [PDF]

Nat Cell Biol
Lennartz HM, da Costa Nunes S, Böhlig K, Chhatre A, Šachl R, Kuhn SM, Moneta L, Barahtjan P, Yee Yau W, Iglesias-Artola JM, Hof M, Opálka L, Modes CD, Honigmann A, Nadler A.   +14 more
europepmc   +1 more source

The tRNA‐Modification Geranyl‐2‐Thiouridine Enables RNA‐Lipid Association

Angewandte Chemie International Edition, EarlyView.
We report the preparation of mono‐ to tri‐geranylated RNA and the association of the hydrophobic RNA with membranes for future efficient incorporation of RNA into liposomes. ABSTRACT The packaging of RNA in lipid nanoparticles for protection and delivery was key for the development of mRNA vaccines and therapeutics. Formulation requires the addition of
Johannes Singer, Kathrin Halter, Chun‐Yin Chan, Thomas Carell   +3 more
wiley   +1 more source

Four subtypes of disease-causing missense mutations underlie pathogenic protein interactions in neurodegenerative VPS13A disease. [PDF]

J Clin Invest
Lin X, Ryoden Y, Suzuki C, Ishikawa H, Sakuragi T, Uchiyama Y, Nagata S.   +6 more
europepmc   +1 more source

The sRNA vvrr1 Modulates the VarS/VarA‐Csr System via LeuO to Regulate Biofilm Formation and Virulence in Vibrio alginolyticus

Animal Research and One Health, EarlyView.
vvrr1, a small RNA, post‐transcriptionally represses the transcriptional regulator LeuO, which directly inhibits the VarS/VarA two‐component system. This triggers a Csr cascade that relieves LuxO repression, ultimately modulating exopolysaccharide production to control biofilm formation and virulence in Vibrio alginolyticus.
Theerakamol Pengsakul, Lei Wen, Lingmin Zhao, Bei Huang, Jiang Zheng, Binfu Xu, Lixing Huang   +6 more
wiley   +1 more source

Temperature as a Regulator of Red Blood Cell Fate: From Membrane Dynamics to Cellular Clearance. [PDF]

Med Sci (Basel)
Barshtein G, Pajić-Lijaković I, Gural A.   +2 more
europepmc   +1 more source