Results 211 to 220 of about 5,974,193 (263)

Targeting lipid scrambling potentiates ferroptosis and triggers tumor immune rejection. [PDF]

Sci Adv
Yang M, Yu Z, Ping J, Duan Y, Tang J, Liu W, He Q, Lai Y, Lam SM, Tang H, Liu Z, Wang W, Zhu M, Hu W, Han Y, Shui G, Hao J, Liu Z, Wu N.   +18 more
europepmc   +1 more source

Distinct Post-Exposure Metabolic States Following Pharmacological Perturbation of Mitochondrial Respiratory Complexes I-V in SH-SY5Y Cells: A Positional ¹³C-NMR Study. [PDF]

Int J Mol Sci
Li H, Baykal AT.
europepmc   +1 more source

Single‐Cell RNA Sequencing and Spatial Multiomics Unveil Microglia–Mural Interactions Underlying Notoginsenoside R1 Against Ischemic Stroke

iMetaMed, EarlyView.
Integrated scRNA‐seq and spatial multiomics provide single‐cell and spatial insights into the neuroprotective effects of NGR1, a clinically validated bioactive compound from Panax notoginseng. NGR1 was associated with a shift in microglial transcriptional states away from ischemia‐associated pro‐inflammatory Adam8hi microglia and toward the protective ...
Qikun Zhao, Wenbo Guo, Yanrong Zheng, Guoqian Cui, Bingjie Wan, Shuhui Deng, Hudong Bao, Xiao Tu, Shengshuang Chen, Jie Liao, Xiaohui Fan   +10 more
wiley   +1 more source

Simulation-based survey of TMEM16 family reveals that robust lipid scrambling requires an open groove. [PDF]

Elife
Stephens CA, van Hilten N, Zheng L, Grabe M.   +3 more
europepmc   +1 more source

GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao, Xianhui Liang, Bingyu Li, Bohan Chen, Xiaoyang Wang, Mei Hong, Qi Feng, Yingjin Qiao, Zhangsuo Liu, Kai Wang, Pei Wang   +10 more
wiley   +1 more source

Human cells for human proteins: Isotope labeling in mammalian cells in suspension for functional NMR studies. [PDF]

Protein Sci
Rößler P, Ruckstuhl MM, Löbbert A, Stühlinger T, Franchini LR, Tsai CJ, Lichtenecker R, Shrestha B, Rüdisser SH, Konrat R, Schertler GFX, Gossert AD.   +11 more
europepmc   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Loss of lipid asymmetry facilitates plasma membrane blebbing by decreasing membrane lipid packing. [PDF]

Proc Natl Acad Sci U S A
Wang HY, Rumin A, Doktorova M, Sputay D, Chan SH, Wehman AM, Levental KR, Levental I.   +7 more
europepmc   +1 more source

Exploring vaginal microbiota–tissue resident stem cell crosstalk: VCAM1/Akt signaling ‐mediated enhancement of regenerative capacity

Interdisciplinary Medicine, EarlyView.
Vaginal microbiota‐derived secretory factors enhance the regenerative capacity of human endometrial stem cells by upregulating VCAM1 and activating PI3K/Akt signaling. This microbiota–stem cell crosstalk promotes self‐renewal, migration, multilineage differentiation, and metabolic reprogramming in vitro and in vivo, establishing a novel microbiota ...
Soo‐Rim Kim, Eun‐Kyung Min, Choon‐Mi Lee, Kun‐Hee Na, Chan Hum Park, YunJae Jung, Hwa‐Yong Lee   +6 more
wiley   +1 more source

NINJ1-mediated membrane rupture bridges cell death to tissue inflammation. [PDF]

Biochem Soc Trans
Tran TU, Le QT, Tu TM, Phan TK.
europepmc   +1 more source