Results 221 to 230 of about 3,949 (239)

Scrambling of Phospholipids Activates Red Cell Membrane Cholesterol [PDF]

Biochemistry, 2007
Cholesterol is predicted to associate more strongly with the outer than the inner leaflet of plasma membrane bilayers based on the relative in vitro affinities of their phospholipids. Complex formation with the high-affinity species (especially saturated sphingomyelins) is said to reduce the chemical activity (escape potential or fugacity) of the ...
Theodore Steck
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Triggering of Erythrocyte Cell Membrane Scrambling by Ursolic Acid

Journal of Natural Products, 2011
Ursolic acid (1), a triterpenoid with pleotropic effects including inhibition of tumor growth, is well known to trigger apoptosis of nucleated cells. The effect is at least partially due to altered gene expression and mitochondrial dysfunction. Erythrocytes lack nuclei and mitochondria but, similar to nucleated cells, may undergo suicidal cell death or
Kashif Jilani, Syed M Qadri, Florian Lang   +2 more
exaly   +3 more sources

Monitoring of membrane phospholipid scrambling in human erythrocytes and K562 cells with FM1-43 — a comparison with annexin V-FITC

Cellular and Molecular Biology Letters, 2014
AbstractThe styryl dye FM1-43 becomes highly fluorescent upon binding to cell membranes. The breakdown of membrane phospholipid asymmetry in ionophore-stimulated T-lymphocytes further increases this fluorescence [Zweifach, 2000]. In this study, the capacity of FM1-43 to monitor membrane phospholipid scrambling was explored using flow cytometry in human
Henry Hägerstrand, Christer Lindqvist, Anna Wröbel   +2 more
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Effect of osmotic shock and urea on phosphatidylserine scrambling in thrombocyte cell membranes

American Journal of Physiology-Cell Physiology, 2010
Blood passing the renal medulla enters a strongly hypertonic environment challenging functional properties and survival of blood cells. In erythrocytes, exposure to hyperosmotic shock stimulates Ca 2+ entry and ceramide formation with subsequent cell membrane scrambling, an effect partially ...
Sergios, Gatidis, Oliver, Borst, Michael, Föller, Florian, Lang   +3 more
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Erythrocyte Shrinkage and Cell Membrane Scrambling after Exposure to the Ionophore Nonactin

Basic & Clinical Pharmacology & Toxicology, 2015
AbstractThe ionophore antibiotic nonactin permeabilizes cell membranes to and K+. Treatment of erythrocytes with nonactin is expected to trigger cellular K+ loss with subsequent cell shrinkage, which in turn is known to trigger suicidal death of a wide variety of cells including erythrocytes.
Thomas, Peter, Rosi, Bissinger, Florian, Lang   +2 more
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Targeting glutathione by dimethylfumarate protects against experimental malaria by enhancing erythrocyte cell membrane scrambling

American Journal of Physiology-Cell Physiology, 2010
The balance between GSH-levels and oxidative stress is critical for cell survival. The GSH-levels of erythrocytes are dramatically decreased during infection with Plasmodium spp. We therefore investigated the consequences of targeting GSH for erythrocyte and Plasmodium survival in vitro and in vivo using dimethylfumarate (DMF) at therapeutically ...
Mehrdad, Ghashghaeinia, Diwakar, Bobbala, Thomas, Wieder, Saisudha, Koka, Jürgen, Brück, Birgit, Fehrenbacher, Martin, Röcken, Martin, Schaller, Florian, Lang, Kamran, Ghoreschi   +9 more
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Chapter Twenty‐One Organelle Intermixing and Membrane Scrambling in Cell Death

2008
In many cell types, intracellular organelles are involved along the progression of cell death. While many studies have focused on individual organelles such as mitochondria, evidence has accumulated that different organelles are simultaneously engaged in dynamic changes induced by death signaling before nuclear alterations are evident.
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Organelle intermixing and membrane scrambling in cell death.

Methods in enzymology, 2009
In many cell types, intracellular organelles are involved along the progression of cell death. While many studies have focused on individual organelles such as mitochondria, evidence has accumulated that different organelles are simultaneously engaged in dynamic changes induced by death signaling before nuclear alterations are evident.
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TMEM16 scramblases thin the membrane to enable lipid scrambling

Nature Communications, 2022
Xiaolu Cheng, Zhang Feng, Alessio Accardi   +2 more
exaly  

Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane

Molecular Cell, 2021
Hiroshi Harada, Jun Suzuki, Hidetaka Kosako   +2 more
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