Results 241 to 250 of about 5,974,193 (263)

Phlorhizin Protects Against Erythrocyte Cell Membrane Scrambling

Journal of Agricultural and Food Chemistry, 2011
Phlorhizin interferes with glucose transport. Glucose depletion triggers suicidal erythrocyte death or eryptosis, characterized by cell shrinkage and cell membrane scrambling. Eryptosis is further triggered by oxidative stress. The present study explored whether phlorhizin influences eryptosis following glucose depletion or oxidative stress.
Kashif Jilani, Syed M Qadri, Sergios Gatidis   +2 more
exaly   +3 more sources

Beauvericin Induced Erythrocyte Cell Membrane Scrambling

Toxicology, 2011
Beauvericin is a mycotoxin with antiviral, antibacterial, nematicidal, insecticidal, cytotoxic, and apoptotic activity. Similar to nucleated cells erythrocytes may undergo suicidal death or eryptosis, which is characterized by cell shrinkage and phosphatidylserine exposure at the erythrocyte surface.
Syed M Qadri, Florian Lang
exaly   +3 more sources

Lipopeptides in the Triggering of Erythrocyte Cell Membrane Scrambling [PDF]

Cellular Physiology and Biochemistry, 2008
Sepsis is paralleled by anemia, an effect partially resulting from eryptosis, the suicidal death of erythrocytes. Eryptosis is characterized by cell membrane scrambling with phosphatidylserine exposure at the erythrocyte surface. Pathogen-induced eryptosis may partially result from interaction of bacterial cell wall components such as lipoproteins with
Karl Sebastian Lang, CV Friedrich Götz, Michael Föller   +2 more
exaly   +3 more sources

Triggering of Erythrocyte Cell Membrane Scrambling by Ursolic Acid

Journal of Natural Products, 2011
Ursolic acid (1), a triterpenoid with pleotropic effects including inhibition of tumor growth, is well known to trigger apoptosis of nucleated cells. The effect is at least partially due to altered gene expression and mitochondrial dysfunction. Erythrocytes lack nuclei and mitochondria but, similar to nucleated cells, may undergo suicidal cell death or
Kashif Jilani, Syed M Qadri, Florian Lang   +2 more
exaly   +3 more sources

Monitoring of Membrane Phospholipid Scrambling in Human Erythrocytes and K562 Cells With FM1-43 — A Comparison With Annexin V-FITC

Cellular and Molecular Biology Letters, 2014
AbstractThe styryl dye FM1-43 becomes highly fluorescent upon binding to cell membranes. The breakdown of membrane phospholipid asymmetry in ionophore-stimulated T-lymphocytes further increases this fluorescence [Zweifach, 2000]. In this study, the capacity of FM1-43 to monitor membrane phospholipid scrambling was explored using flow cytometry in human
Henry Hägerstrand, Malgorzata Bobrowska-Hägerstrand, Anna Wróbel   +2 more
exaly   +3 more sources

Effect of osmotic shock and urea on phosphatidylserine scrambling in thrombocyte cell membranes

American Journal of Physiology-Cell Physiology, 2010
Blood passing the renal medulla enters a strongly hypertonic environment challenging functional properties and survival of blood cells. In erythrocytes, exposure to hyperosmotic shock stimulates Ca 2+ entry and ceramide formation with subsequent cell membrane scrambling, an effect partially ...
Sergios, Gatidis, Oliver, Borst, Michael, Föller, Florian, Lang   +3 more
openaire   +2 more sources

Erythrocyte Shrinkage and Cell Membrane Scrambling after Exposure to the Ionophore Nonactin

Basic & Clinical Pharmacology & Toxicology, 2015
AbstractThe ionophore antibiotic nonactin permeabilizes cell membranes to and K+. Treatment of erythrocytes with nonactin is expected to trigger cellular K+ loss with subsequent cell shrinkage, which in turn is known to trigger suicidal death of a wide variety of cells including erythrocytes.
Thomas, Peter, Rosi, Bissinger, Florian, Lang   +2 more
openaire   +2 more sources

Targeting glutathione by dimethylfumarate protects against experimental malaria by enhancing erythrocyte cell membrane scrambling

American Journal of Physiology-Cell Physiology, 2010
The balance between GSH-levels and oxidative stress is critical for cell survival. The GSH-levels of erythrocytes are dramatically decreased during infection with Plasmodium spp. We therefore investigated the consequences of targeting GSH for erythrocyte and Plasmodium survival in vitro and in vivo using dimethylfumarate (DMF) at therapeutically ...
Mehrdad, Ghashghaeinia, Diwakar, Bobbala, Thomas, Wieder, Saisudha, Koka, Jürgen, Brück, Birgit, Fehrenbacher, Martin, Röcken, Martin, Schaller, Florian, Lang, Kamran, Ghoreschi   +9 more
openaire   +2 more sources

Chapter Twenty‐One Organelle Intermixing and Membrane Scrambling in Cell Death

2008
In many cell types, intracellular organelles are involved along the progression of cell death. While many studies have focused on individual organelles such as mitochondria, evidence has accumulated that different organelles are simultaneously engaged in dynamic changes induced by death signaling before nuclear alterations are evident.
openaire   +2 more sources

Organelle intermixing and membrane scrambling in cell death.

Methods in enzymology, 2009
In many cell types, intracellular organelles are involved along the progression of cell death. While many studies have focused on individual organelles such as mitochondria, evidence has accumulated that different organelles are simultaneously engaged in dynamic changes induced by death signaling before nuclear alterations are evident.
openaire   +1 more source