Results 91 to 100 of about 273,445 (144)
Role of CAP350 in centriolar tubule stability and centriole assembly.
PLoS ONE, 2008 BackgroundCentrioles are microtubule-based cylindrical structures composed of nine triplet tubules and are required for the formation of the centrosome, flagella and cilia. Despite theirs importance, centriole biogenesis is poorly understood.
Mikael Le Clech
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Cell Death and Disease, 2018 Polo-like kinase 4 (PLK4) is indispensable for precise control of centriole duplication. Abnormal expression of PLK4 has been reported in many human cancers, and inhibition of PLK4 activity results in their mitotic arrest and apoptosis.
Qian Lei +12 more
semanticscholar +1 more source
Biology Open, 2017 A small number of proteins form a conserved pathway of centriole duplication. In humans and flies, the binding of PLK4/Sak to STIL/Ana2 initiates daughter centriole assembly.
Matthew A. Cottee +3 more
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Differential turnover of Nup188 controls its levels at centrosomes and role in centriole duplication
bioRxiv, 2019 NUP188 encodes a scaffold component of the nuclear pore complex (NPC) and has been implicated as a congenital heart disease gene through an ill-defined function at centrioles.
Nidhi Vishnoi +5 more
semanticscholar +1 more source
Vesicular trafficking plays a role in centriole disengagement and duplication
Molecular Biology of the Cell, 2018 Centrosomes are the major microtubule-nucleating and microtubule-organizing centers of cells and play crucial roles in microtubule anchoring, organelle positioning, and ciliogenesis. At the centrosome core lies a tightly associated or “engaged” mother–daughter centriole pair.
Xie, Shuwei +9 more
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The EMBO JournalCentrioles play a central role in cell division by recruiting pericentriolar material (PCM) to form the centrosome. Alterations in centriole number or function lead to various diseases including cancer or microcephaly.
Marine Brunet +8 more
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eLife, 2015 Centrioles are microtubule-based organelles crucial for cell division, sensing and motility. In Caenorhabditis elegans, the onset of centriole formation requires notably the proteins SAS-5 and SAS-6, which have functional equivalents across eukaryotic ...
Kacper B Rogala +8 more
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Genes to Cells, 2019 RNA‐binding motif protein 10 (RBM10) primarily regulates alternative splicing of certain genes. Loss‐of‐function mutations in RBM10 have been frequently reported in patients with various cancers.
H. Kunimoto +6 more
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Current biology : CB, 2001 Centriole duplication is a key step in the cell cycle whose mechanism is completely unknown. Why new centrioles always form next to preexisting ones is a fundamental question. The simplest model is that preexisting centrioles nucleate the assembly of new centrioles, and that although centrioles can in some cases form de novo without this nucleation ...
Marshall, Wallace F +2 more
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A genome-wide RNAi screen to dissect centriole duplication and centrosome maturation in Drosophila.
PLoS Biology, 2008 Centrosomes comprise a pair of centrioles surrounded by an amorphous pericentriolar material (PCM). Here, we have performed a microscopy-based genome-wide RNA interference (RNAi) screen in Drosophila cells to identify proteins required for centriole ...
Jeroen Dobbelaere +5 more
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