Results 91 to 100 of about 3,540 (186)

TENT5C functions as a corepressor in the ligand‐bound glucocorticoid receptor and estrogen receptor α complexes

The FEBS Journal, Volume 292, Issue 19, Page 5168-5184, October 2025.
TENT5C is a suppressor of ERα and GR transcriptional activation. A specific LXXLL motif in TENT5C, absent in the other members of the TENT5 subfamily, mediates a stable interaction with the Ligand Binding Domain of ERα but not with that of GR.
Yin Li, Lalith Perera, Rebecca S. He, Marine Baptissart, Robert M. Petrovich, Marcos Morgan   +5 more
wiley   +1 more source

Cep152 interacts with Plk4 and is required for centriole duplication [PDF]

Journal of Cell Biology, 2010
Centrioles are microtubule-based structures that organize the centrosome and nucleate cilia. Centrioles duplicate once per cell cycle, and duplication requires Plk4, a member of the Polo-like kinase family; however, the mechanism linking Plk4 activity and centriole formation is unknown. In this study, we show in human and frog cells that Plk4 interacts
Hatch, Emily M, Kulukian, Anita, Holland, Andrew J, Cleveland, Don W, Stearns, Tim   +4 more
openaire   +4 more sources

Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly

eLife, 2013
Centrioles organise centrosomes and template cilia and flagella. Several centriole and centrosome proteins have been linked to microcephaly (MCPH), a neuro-developmental disease associated with small brain size. CPAP (MCPH6) and STIL (MCPH7) are required
Matthew A Cottee, Nadine Muschalik, Yao Liang Wong, Christopher M Johnson, Steven Johnson, Antonina Andreeva, Karen Oegema, Susan M Lea, Jordan W Raff, Mark van Breugel   +9 more
doaj   +1 more source

Avian Lifespan Network Reveals Shared Mechanisms and New Key Players in Animal Longevity

Aging Cell, Volume 24, Issue 9, September 2025.
In this work, we found that birds with similar lifespans exhibit convergent evolution in specific genes, suggesting that shared evolutionary pressures shape the genetic basis of lifespan similarity across species. By investigating protein–protein interactions across genes evolving convergently in long‐ and short‐lived species, we identified a network ...
Mirko Martini, Giovanni Piccinini, Liliana Milani, Mariangela Iannello   +3 more
wiley   +1 more source

Drosophila Spd-2 Recruits PCM to the Sperm Centriole, but Is Dispensable for Centriole Duplication

Current Biology, 2007
In C. elegans, genome-wide screens have identified just five essential centriole-duplication factors: SPD-2, ZYG-1, SAS-5, SAS-6, and SAS-4 [1-8]. These proteins are widely believed to comprise a conserved core duplication module [3, 9-14]. In worm embryos, SPD-2 is the most upstream component of this module, and it is also essential for pericentriolar
Dix, C, Raff, J
openaire   +3 more sources

De novo centriole formation in human cells is error-prone and does not require SAS-6 self-assembly

eLife, 2015
Vertebrate centrioles normally propagate through duplication, but in the absence of preexisting centrioles, de novo synthesis can occur. Consistently, centriole formation is thought to strictly rely on self-assembly, involving self-oligomerization of the
Won-Jing Wang, Devrim Acehan, Chien-Han Kao, Wann-Neng Jane, Kunihiro Uryu, Meng-Fu Bryan Tsou   +5 more
doaj   +1 more source

Reminiscent of the pre‐diatom? A hitherto undescribed scaly bolidophyte Lepidoparma frigida gen. et sp. nov. in a new order Lepidoparmales based on morphology, phylogeny, and ecology

Journal of Phycology, Volume 61, Issue 4, Page 757-776, August 2025.
Abstract The class Bolidophyceae, which consists of small phytoplankton distributed worldwide, is the sister group of diatoms. This class has contained only one order, the Parmales, until now. In this study, we established a new order Lepidoparmales Kamakura & S.Sato ord. nov. and a new family Lepidoparmaceae Kamakura & S.Sato fam.
Shiho Kamakura, Kazumasa Yamada, Eldrin D. L. R. Arguelles, Akira Kuwata, Tamotsu Nagumo, Masakazu Takahashi, Ken Sawada, Mutsuo Ichinomiya, Shinya Sato   +8 more
wiley   +1 more source

CEP162: A critical regulator of ciliary transition zone assembly and its implications in ciliopathies

Journal of Cell Communication and Signaling, Volume 19, Issue 2, June 2025.
Abstract CEP162, a 162‐kDa centrosome protein, is a crucial centrosomal adapter, mediating cell differentiation and polarization. CEP162 maintains mitosis by dynamically stabilizing microtubules. CEP162 promotes the transition zone (TZ) assembly in the basal body through interaction with CEP131, CEP290, and axoneme microtubules as well as the distal ...
Jun Yin, Jialian Bai, Xiaochong He, Wenjuan He, Hongming Miao, Mengjie Zhang, Zhongying Yu, Bing Ni   +7 more
wiley   +1 more source

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio, Volume 15, Issue 5, Page 856-866, May 2025.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
wiley   +1 more source

Role of CAP350 in centriolar tubule stability and centriole assembly.

PLoS ONE, 2008
BackgroundCentrioles are microtubule-based cylindrical structures composed of nine triplet tubules and are required for the formation of the centrosome, flagella and cilia. Despite theirs importance, centriole biogenesis is poorly understood.
Mikael Le Clech
doaj   +1 more source