Results 111 to 120 of about 273,445 (144)

Studying Centriole Duplication and Elongation in Human Cells.

Methods in molecular biology, 2020
Centrioles assemble centrosomes and cilia/flagella, which are microtubule-based structures with key roles in cell division, polarity, motility, and signaling. Centriole biogenesis is a tightly regulated process, and deregulation of centriole numbers and structure can have dramatic consequences for cellular function and integrity.
Catarina Peneda, Carla A M Lopes, M. Bettencourt-Dias   +2 more
semanticscholar   +3 more sources

Uncoiling centriole duplication

Nature Cell Biology, 2004
The invariant duplication of the centriole once per cell cycle is critical for cell division. SAS-5 is the most recent of three coiled-coil centriolar proteins found to be required for centriole duplication in Caenorhabditis elegans.
Bruce Nash, Bruce Bowerman
openaire   +1 more source

Meiotic divisions and round spermatid formation do not require centriole duplication in mice

PLoS Genetics
Centrosomes, composed of centrioles and pericentriolar matrix proteins, are traditionally viewed as essential microtubule-organizing centers (MTOCs) that facilitate bipolar spindle formation and chromosome segregation during spermatogenesis.
Marnie W Skinner, Paula B Nhan, Carter J. Simington, Philip W. Jordan   +3 more
semanticscholar   +1 more source

The Polo kinase Plk4 functions in centriole duplication

Nature Cell Biology, 2005
The human Polo-like kinase 1 (PLK1) and its functional homologues that are present in other eukaryotes have multiple, crucial roles in meiotic and mitotic cell division. By contrast, the functions of other mammalian Polo family members remain largely unknown.
Habedanck, Robert, Stierhof, York-Dieter, Wilkinson, Christopher J., Nigg, Erich A.   +3 more
openaire   +3 more sources

PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential

Cytoskeleton
Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the ...
Muhammad Hamzah, Franz Meitinger, Midori Ohta   +2 more
semanticscholar   +1 more source

The A-C linker controls centriole structural integrity and duplication

Nature Communications
Centrioles are evolutionarily conserved barrel-shaped organelles playing crucial roles in cell division and ciliogenesis. These functions are underpinned by specific structural sub-elements whose functions have been under investigation since many years ...
Lorène Bournonville, Marine. H. Laporte, S. Borgers, Paul Guichard, V. Hamel   +4 more
semanticscholar   +1 more source

Centriole Duplication in Lysates of Spisula solidissima Oocytes

Science, 1992
A cell-free system has been developed that executes centriole duplication. Surf clam ( Spisula solidissima ) oocytes, arrested at late prophase of meiosis I, do not contain centrioles, centrosomes, or asters. Serial section high-voltage electron microscopy (HVEM) of asters and spindles isolated from potassium ...
R E, Palazzo, E, Vaisberg, R W, Cole, C L, Rieder   +3 more
openaire   +2 more sources

Centriole duplication and orientation in mammalian cells

Medical Hypotheses, 1999
The paper discusses a mechanism for semiconservative duplication of a pair of centrioles from a single parent. The mechanism accounts for the (transient or permanent) quasi-orthogonality of mammalian centrioles.
openaire   +2 more sources

ɛ-Tubulin is required for centriole duplication and microtubule organization

Nature Cell Biology, 2002
Centrosomes nucleate microtubules and serve as poles of the mitotic spindle. Centrioles are a core component of centrosomes and duplicate once per cell cycle. We previously identified epsilon-tubulin as a new member of the tubulin superfamily that localizes asymmetrically to the two centrosomes after duplication.
Paul, Chang, Thomas H, Giddings, Mark, Winey, Tim, Stearns   +3 more
openaire   +2 more sources

Centriole Duplication and Inheritance in Drosophila melanogaster

2012
Centrosomes are conserved microtubule-based organelles that are essential for animal development. In this chapter, we highlight key centrosomal proteins and describe the centrosome in the context of several developmental processes in Drosophila melanogaster.
Tomer Avidor-Reiss, Jayachandran Gopalakrishnan, Stephanie Blachon, Andrey Polyanovsky   +3 more
openaire   +1 more source