Results 21 to 30 of about 273,445 (144)
Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication. [PDF]
PLoS Genetics, 2017 In humans perturbations of centriole number are associated with tumorigenesis and microcephaly, therefore appropriate regulation of centriole duplication is critical. The C.
Nina Peel +5 more
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Centriole Duplication: Centrin in on Answers? [PDF]
Current Biology, 2002 Many aspects of centriole biology remain mysterious. A new study has shed light on the role of the centriolar protein centrin-2: reducing levels of centrin-2 in HeLa cells has been found to block centriole duplication, eventually leading to cell death.
Rice, Luke M, Agard, David A
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PLoS Genetics, 2022 Centrioles are submicron-scale, barrel-shaped organelles typically found in pairs, and play important roles in ciliogenesis and bipolar spindle assembly.
Jyoti Iyer +10 more
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The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number [PDF]
Open Biology, 2018 Deregulation of centriole duplication has been implicated in cancer and primary microcephaly. Accordingly, it is important to understand how key centriole duplication factors are regulated.
Christian Arquint +4 more
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PLoS Biology, 2023 Centrioles duplicate when a mother centriole gives birth to a daughter that grows from its side. Polo-like-kinase 4 (PLK4), the master regulator of centriole duplication, is recruited symmetrically around the mother centriole, but it then concentrates at
Z. Wilmott, Alain Goriely, J. Raff
semanticscholar +1 more source
Communications Biology, 2023 Proper organization of intracellular assemblies is fundamental for efficient promotion of biochemical processes and optimal assembly functionality. Although advances in imaging technologies have shed light on how the centrosome is organized, how its ...
Jong Il Ahn +19 more
semanticscholar +1 more source
Centriole Duplication: When PLK4 Meets Ana2/STIL [PDF]
Current Biology, 2014 Polo-like kinase 4 is known to drive centriole duplication, but the relevant substrate remains elusive. A new study shows that PLK4 phosphorylates a key centriolar component, Ana2/STIL, to initiate centriole assembly.
Kim, Minhee +2 more
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Genes & Development, 2022 In this study, Phan et al. show that PLK4 abundance is translationally controlled through conserved upstream open reading frames (uORFs) in the 5′ UTR of the mRNA and that Plk4 uORFs suppress Plk4 translation and prevent excess protein synthesis.
Thao P Phan +6 more
semanticscholar +1 more source
Mode of centriole duplication and distribution. [PDF]
The Journal of cell biology, 1990 Centriole stability and distribution during the mammalian cell cycle was studied by microinjecting biotinylated tubulin into early G1 cells and analyzing the pattern of incorporation into centrioles. Cells were extracted and cold treated to depolymerize labile microtubules, allowing the fluorescent microscopic visualization of the stable centrioles ...
R S, Kochanski, G G, Borisy
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A Short CEP135 Splice Isoform Controls Centriole Duplication [PDF]
Current Biology, 2015 Centriole duplication is coordinated such that a single round of duplication occurs during each cell cycle. Disruption of this synchrony causes defects including supernumerary centrosomes in cancer and perturbed ciliary signaling [1-5]. To preserve the normal number of centrioles, the level, localization, and post-translational modification of ...
Dahl, Kristin D. +7 more
openaire +2 more sources