Results 21 to 30 of about 3,540 (186)

PLK4 promotes centriole duplication by phosphorylating STIL to link the procentriole cartwheel to the microtubule wall [PDF]

eLife, 2019
Centrioles play critical roles in organizing the assembly of the mitotic spindle and templating the formation of primary cilia. Centriole duplication occurs once per cell cycle and is regulated by Polo-like kinase 4 (PLK4).
Tyler Chistopher Moyer, Andrew Jon Holland   +1 more
doaj   +2 more sources

The RAC1 activator Tiam1 regulates centriole duplication through controlling PLK4 levels. [PDF]

J Cell Sci, 2021
Porter AP, Reed H, White GRM, Ogg EL, Whalley HJ, Malliri A.   +5 more
europepmc   +2 more sources

Plk4-dependent phosphorylation of STIL is required for centriole duplication [PDF]

Biology Open, 2015
Duplication of centrioles, namely the formation of a procentriole next to the parental centriole, is regulated by the polo-like kinase Plk4. Only a few other proteins, including STIL (SCL/TAL1 interrupting locus, SIL) and Sas-6, are required for the ...
Anne-Sophie Kratz, Felix Bärenz, Kai T. Richter, Ingrid Hoffmann   +3 more
doaj   +2 more sources

The ubiquitin ligase FBXW7 targets the centriolar assembly protein HsSAS-6 for degradation and thereby regulates centriole duplication. [PDF]

J Biol Chem, 2020
Badarudeen B, Gupta R, Nair SV, Chandrasekharan A, Manna TK.   +4 more
europepmc   +3 more sources

A theory of centriole duplication based on self-organized spatial pattern formation. [PDF]

J Cell Biol, 2019
Takao D, Yamamoto S, Kitagawa D.
europepmc   +3 more sources

Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis

Nature Communications, 2019
Regulation of centriole duplication is essential for normal chromosome segregation and the maintenance of genomic stability, and Polo-like kinase 4 (Plk4) is a known regulator with unclear mechanisms.
Jung-Eun Park, Liang Zhang, Jeong kyu Bang   +2 more
exaly   +2 more sources

STIL binding to Polo-box 3 of PLK4 regulates centriole duplication

eLife, 2015
Polo-like kinases (PLK) are eukaryotic regulators of cell cycle progression, mitosis and cytokinesis; PLK4 is a master regulator of centriole duplication.
Christian Arquint, Anna-Maria Gabryjonczyk, Stefan Imseng, Raphael Böhm, Evelyn Sauer, Sebastian Hiller, Erich A Nigg, Timm Maier   +7 more
doaj   +2 more sources

The DNA replication machinery transmits dual signals to prevent unscheduled licensing and execution of centrosome duplication [PDF]

Nature Communications
Copy number control of DNA and centrosomes is essential for accurate genetic inheritance. DNA replication and centrosome duplication have been recognized as parallel key events for cell division.
Kyohei Matsuhashi, Kei K. Ito, Kaho Nagai, Akira Sanada, Koki Watanabe, Kasuga Takumi, Atsushi Toyoda, Masamitsu Fukuyama, Shohei Yamamoto, Takumi Chinen, Grant S. Stewart, Shoji Hata, Daiju Kitagawa   +12 more
doaj   +2 more sources

CRL4^DCAF1 ubiquitin ligase regulates PLK4 protein levels to prevent premature centriole duplication. [PDF]

Life Sci Alliance
Grossmann J, Kratz AS, Kordonsky A, Prag G, Hoffmann I.   +4 more
europepmc   +3 more sources

Centriole Duplication: When PLK4 Meets Ana2/STIL [PDF]

Current Biology, 2014
Polo-like kinase 4 is known to drive centriole duplication, but the relevant substrate remains elusive. A new study shows that PLK4 phosphorylates a key centriolar component, Ana2/STIL, to initiate centriole assembly.
Minhee Kim, Chii Shyang Fong, Meng-Fu Bryan Tsou   +2 more
openalex   +3 more sources