Results 31 to 40 of about 273,445 (144)
Centrioles: Duplicating Precariously [PDF]
Current Biology, 2007 To assemble a mitotic spindle and accurately segregate chromosomes to progeny, a cell needs to precisely regulate its centrosome number, a feat largely accomplished through the tight control of centriole duplication. Recent work showing that the overexpression of centriolar proteins can lead to the formation of multiple centrioles in the absence of pre-
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Centriole duplication: analogue control in a digital age [PDF]
Cell Biology International, 2010 AbstractIn preparation for mitosis, the centrosome doubles once and only once to provide the two poles of the mitotic spindle. The presence of more than two centrosomes increases the chances that mitosis will be multipolar, and chromosomes will be distributed unequally.
Sluder, Greenfield, Khodjakov, Alexey
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Talpid3-binding centrosomal protein Cep120 is required for centriole duplication and proliferation of cerebellar granule neuron progenitors. [PDF]
PLoS ONE, 2014 Granule neuron progenitors (GNPs) are the most abundant neuronal type in the cerebellum. GNP proliferation and thus cerebellar development require Sonic hedgehog (Shh) secreted from Purkinje cells.
Chuanqing Wu +6 more
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The E2F-DP1 Transcription Factor Complex Regulates Centriole Duplication in Caenorhabditis elegans
G3: Genes, Genomes, Genetics, 2016 Centrioles play critical roles in the organization of microtubule-based structures, from the mitotic spindle to cilia and flagella. In order to properly execute their various functions, centrioles are subjected to stringent copy number control.
Jacqueline G. Miller +4 more
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PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells
eLife, 2022 Multiciliated cells (MCCs) are terminally differentiated epithelia that assemble multiple motile cilia used to promote fluid flow. To template these cilia, MCCs dramatically expand their centriole content during a process known as centriole amplification.
Gina M LoMastro +5 more
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Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication
Genes & Development, 2022 In this Outlook, Ryniawec and Rogers highlight a study in this issue by Phan et al. describing a new mechanism of control that restricts Plk4 translation through competitive ribosome binding at upstream open reading frames (uORFs) in the mature Plk4 mRNA.
John M. Ryniawec, G. C. Rogers
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Drosophila Ana2 is a conserved centriole duplication factor [PDF]
Journal of Cell Biology, 2010 In Caenorhabditis elegans, five proteins are required for centriole duplication: SPD-2, ZYG-1, SAS-5, SAS-6, and SAS-4. Functional orthologues of all but SAS-5 have been found in other species. In Drosophila melanogaster and humans, Sak/Plk4, DSas-6/hSas-6, and DSas-4/CPAP—orthologues of ZYG-1, SAS-6, and SAS-4, respectively—are required for centriole ...
Stevens, Naomi +4 more
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bioRxiv, 2021 Centrosomes are microtubule-organizing centers that duplicate exactly once to organize the bipolar mitotic spindle required for error-free mitosis. Prior work indicated that Drosophila centrocortin (cen) is required for normal centrosome separation ...
Dipen S. Mehta +4 more
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Centrin Regulates Centriole Duplication [PDF]
Microscopy and Microanalysis, 2006 Extended abstract of a paper presented at Microscopy and Microanalysis 2006 in Chicago, Illinois, USA, July 30 – August 3 ...
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Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication [PDF]
The Journal of Cell Biology, 2008 Centrosome duplication is tightly controlled in coordination with DNA replication. The molecular mechanism of centrosome duplication remains unclear. Previous studies found that a fraction of human proline-directed phosphatase Cdc14B associates with centrosomes. However, Cdc14B's involvement in centrosome cycle control has never been explored. Here, we
Wu, Jun +6 more
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