CCHCR1-astrin interaction promotes centriole duplication through recruitment of CEP72. [PDF]
BMC Biol, 2022 AbstractBackgroundThe centrosome is one of the most important non-membranous organelles regulating microtubule organization and progression of cell mitosis. The coiled-coil alpha-helical rod protein 1 (CCHCR1, also known as HCR) gene is considered to be a psoriasis susceptibility gene, and the protein is suggested to be localized to the P-bodies and ...
Ying Z +12 more
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SFI1 promotes centriole duplication by recruiting USP9X to stabilize the microcephaly protein STIL. [PDF]
J Cell Biol, 2019 Kodani A +5 more
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Centrioles: Duplicating Precariously [PDF]
Current Biology, 2007 To assemble a mitotic spindle and accurately segregate chromosomes to progeny, a cell needs to precisely regulate its centrosome number, a feat largely accomplished through the tight control of centriole duplication. Recent work showing that the overexpression of centriolar proteins can lead to the formation of multiple centrioles in the absence of pre-
Laurence Pelletier
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c-Cbl Acts as an E3 Ligase Against DDA3 for Spindle Dynamics and Centriole Duplication during Mitosis. [PDF]
Mol Cells, 2019 Gwon D, Hong J, Jang CY.
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SAK/PLK4 Is Required for Centriole Duplication and Flagella Development [PDF]
Current Biology, 2005 SAK/PLK4 is a distinct member of the polo-like kinase family. SAK-/- mice die during embryogenesis, whereas SAK+/- mice develop liver and lung tumors and SAK+/- MEFs show mitotic abnormalities. However, the mechanism underlying these phenotypes is still not known.Here, we show that downregulation of SAK in Drosophila cells, by mutation or RNAi, leads ...
Mónica Bettencourt‐Dias +9 more
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Once and only once: mechanisms of centriole duplication and their deregulation in disease [PDF]
Nature Reviews Molecular Cell Biology, 2018 Erich A Nigg, Andrew J Holland
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Centriole Duplication: Centrin in on Answers? [PDF]
Current Biology, 2002 Many aspects of centriole biology remain mysterious. A new study has shed light on the role of the centriolar protein centrin-2: reducing levels of centrin-2 in HeLa cells has been found to block centriole duplication, eventually leading to cell death.
Luke M. Rice, David A. Agard
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Ubiquitin signaling in the control of centriole duplication [PDF]
The FEBS Journal, 2021 The centrosome plays an essential role in maintaining genetic stability, ciliogenesis and cell polarisation. The core of the centrosome is made up of two centrioles that duplicate precisely once during every cell cycle to generate two centrosomes that are required for bipolar spindle assembly and chromosome segregation.
Binshad Badarudeen +3 more
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Autoamplification and Competition Drive Symmetry Breaking: Initiation of Centriole Duplication by the PLK4-STIL Network. [PDF]
iScience, 2018 Leda M, Holland AJ, Goryachev AB.
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Open Biology, 2022 Centrosomes are important organizers of microtubules within animal cells. They comprise a pair of centrioles surrounded by the pericentriolar material, which nucleates and organizes the microtubules.
Neil H. J. Cunningham +2 more
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