Results 41 to 50 of about 3,540 (186)
CDK11(p58) is required for centriole duplication and Plk4 recruitment to mitotic centrosomes. [PDF]
PLoS ONE, 2011 BACKGROUND: CDK11(p58) is a mitotic protein kinase, which has been shown to be required for different mitotic events such as centrosome maturation, chromatid cohesion and cytokinesis.
Nathalie Franck +5 more
doaj +1 more source
A Short CEP135 Splice Isoform Controls Centriole Duplication. [PDF]
Curr Biol, 2015 Centriole duplication is coordinated such that a single round of duplication occurs during each cell cycle. Disruption of this synchrony causes defects including supernumerary centrosomes in cancer and perturbed ciliary signaling [1-5]. To preserve the normal number of centrioles, the level, localization, and post-translational modification of ...
Dahl KD +7 more
europepmc +4 more sources
Cell Cycle, 2010 In interphase and mitosis, centrosomes play a major role in the spatial organization of the microtubule network. Alterations in centrosome number and structure are associated with genomic instability and occur in many cancers. Centrosome duplication is controlled by centriole replication.
Andrew J, Holland +2 more
openaire +2 more sources
PLoS Genetics, 2022 Centrioles are submicron-scale, barrel-shaped organelles typically found in pairs, and play important roles in ciliogenesis and bipolar spindle assembly.
Jyoti Iyer +10 more
doaj +1 more source
The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number [PDF]
Open Biology, 2018 Deregulation of centriole duplication has been implicated in cancer and primary microcephaly. Accordingly, it is important to understand how key centriole duplication factors are regulated.
Christian Arquint +4 more
doaj +1 more source
Mode of centriole duplication and distribution. [PDF]
The Journal of cell biology, 1990 Centriole stability and distribution during the mammalian cell cycle was studied by microinjecting biotinylated tubulin into early G1 cells and analyzing the pattern of incorporation into centrioles. Cells were extracted and cold treated to depolymerize labile microtubules, allowing the fluorescent microscopic visualization of the stable centrioles ...
R S, Kochanski, G G, Borisy
openaire +2 more sources
PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells
eLife, 2022 Multiciliated cells (MCCs) are terminally differentiated epithelia that assemble multiple motile cilia used to promote fluid flow. To template these cilia, MCCs dramatically expand their centriole content during a process known as centriole amplification.
Gina M LoMastro +5 more
doaj +1 more source
Centriole duplication: analogue control in a digital age [PDF]
Cell Biology International, 2010 AbstractIn preparation for mitosis, the centrosome doubles once and only once to provide the two poles of the mitotic spindle. The presence of more than two centrosomes increases the chances that mitosis will be multipolar, and chromosomes will be distributed unequally.
Sluder, Greenfield, Khodjakov, Alexey
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Drosophila Ana2 is a conserved centriole duplication factor [PDF]
Journal of Cell Biology, 2010 In Caenorhabditis elegans, five proteins are required for centriole duplication: SPD-2, ZYG-1, SAS-5, SAS-6, and SAS-4. Functional orthologues of all but SAS-5 have been found in other species. In Drosophila melanogaster and humans, Sak/Plk4, DSas-6/hSas-6, and DSas-4/CPAP—orthologues of ZYG-1, SAS-6, and SAS-4, respectively—are required for centriole ...
Stevens, Naomi +4 more
openaire +2 more sources
Centrin Regulates Centriole Duplication [PDF]
Microscopy and Microanalysis, 2006 Extended abstract of a paper presented at Microscopy and Microanalysis 2006 in Chicago, Illinois, USA, July 30 – August 3 ...
openaire +1 more source