Results 41 to 50 of about 273,445 (144)

Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication

eLife, 2015
Primary microcephaly (MCPH) associated proteins CDK5RAP2, CEP152, WDR62 and CEP63 colocalize at the centrosome. We found that they interact to promote centriole duplication and form a hierarchy in which each is required to localize another to the ...
Andrew Kodani, Timothy W Yu, Jeffrey R Johnson, Divya Jayaraman, Tasha L Johnson, Lihadh Al-Gazali, Lāszló Sztriha, Jennifer N Partlow, Hanjun Kim, Alexis L Krup, Alexander Dammermann, Nevan J Krogan, Christopher A Walsh, Jeremy F Reiter   +13 more
doaj   +1 more source

Centriolar SAS-7 acts upstream of SPD-2 to regulate centriole assembly and pericentriolar material formation

eLife, 2017
The centriole/basal body is a eukaryotic organelle that plays essential roles in cell division and signaling. Among five known core centriole proteins, SPD-2/Cep192 is the first recruited to the site of daughter centriole formation and regulates the ...
Kenji Sugioka, Danielle R Hamill, Joshua B Lowry, Marie E McNeely, Molly Enrick, Alyssa C Richter, Lauren E Kiebler, James R Priess, Bruce Bowerman   +8 more
doaj   +1 more source

Dissociating the Centrosomal Matrix Protein AKAP450 from Centrioles Impairs Centriole Duplication and Cell Cycle Progression [PDF]

Molecular Biology of the Cell, 2003
Centrosomes provide docking sites for regulatory molecules involved in the control of the cell division cycle. The centrosomal matrix contains several proteins, which anchor kinases and phosphatases. The large A-Kinase Anchoring Protein AKAP450 is acting as a scaffolding protein for other components of the cell signaling machinery.
Keryer, G., Witczak, O., Delouvée, A., Kemmner, W., Rouillard, D., Taskén, K., Bornens, M.   +6 more
openaire   +3 more sources

Ab ovo or de novo? Mechanisms of Centriole Duplication [PDF]

Molecules and Cells, 2009
The centrosome, an organelle comprising centrioles and associated pericentriolar material, is the major microtubule organizing center in animal cells. For the cell to form a bipolar mitotic spindle and ensure proper chromosome segregation at the end of each cell cycle, it is paramount that the cell contains two and only two centrosomes.
Jadranka, Loncarek, Alexey, Khodjakov
openaire   +2 more sources

Experimental and Natural Induction of de novo Centriole Formation

Frontiers in Cell and Developmental Biology, 2022
In cycling cells, new centrioles are assembled in the vicinity of pre-existing centrioles. Although this canonical centriole duplication is a tightly regulated process in animal cells, centrioles can also form in the absence of pre-existing centrioles ...
Kasuga Takumi, Daiju Kitagawa
doaj   +1 more source

SAS-6 Assembly Templated by the Lumen of Cartwheel-less Centrioles Precedes Centriole Duplication [PDF]

Developmental Cell, 2014
Centrioles are 9-fold symmetric structures duplicating once per cell cycle. Duplication involves self-oligomerization of the centriolar protein SAS-6, but how the 9-fold symmetry is invariantly established remains unclear. Here, we found that SAS-6 assembly can be shaped by preexisting (or mother) centrioles.
Fong, Chii Shyang, Kim, Minhee, Yang, T. Tony, Liao, Jung-Chi, Tsou, Meng-Fu Bryan   +4 more
openaire   +3 more sources

STIL is required for centriole duplication in human cells [PDF]

Journal of Cell Science, 2012
Centrioles are key structural elements of centrosomes and primary cilia. In mammals, only a few proteins including PLK4, CPAP (CENPJ), SAS6, CEP192, CEP152 and CEP135 have thus far been identified to be required for centriole duplication. STIL (SCL/TAL1 interrupting locus, also known as SIL) is a centrosomal protein that is essential for mouse and ...
Julia, Vulprecht, Ahuvit, David, Alexandra, Tibelius, Asher, Castiel, Gleb, Konotop, Fengying, Liu, Felix, Bestvater, Marc S, Raab, Hanswalter, Zentgraf, Shai, Izraeli, Alwin, Krämer   +10 more
openaire   +2 more sources

p53 protects against genome instability following centriole duplication failure [PDF]

Journal of Cell Biology, 2015
Centriole function has been difficult to study because of a lack of specific tools that allow persistent and reversible centriole depletion. Here we combined gene targeting with an auxin-inducible degradation system to achieve rapid, titratable, and reversible control of Polo-like kinase 4 (Plk4), a master regulator of centriole biogenesis.
Lambrus, Bramwell G., Uetake, Yumi, Clutario, Kevin M., Daggubati, Vikas, Snyder, Michael, Sluder, Greenfield, Holland, Andrew J.   +6 more
openaire   +3 more sources

Requirement of the Cep57-Cep63 Interaction for Proper Cep152 Recruitment and Centriole Duplication

Molecular and Cellular Biology, 2020
Cep57 has been characterized as a component of a pericentriolar complex containing Cep63 and Cep152. Interestingly, Cep63 and Cep152 self-assemble into a pericentriolar cylindrical architecture, and this event is critical for the orderly recruitment of ...
Zhuang Wei, Tae-Sung Kim, J. I. Ahn, Lingjun Meng, Yaozong Chen, E. Ryu, B. Ku, Ming Zhou, Seung Jun Kim, J. Bang, J. V. van Deursen, Jung-Eun Park, Kyung S. Lee   +12 more
semanticscholar   +1 more source

CCDC57 Cooperates with Microtubules and Microcephaly Protein CEP63 and Regulates Centriole Duplication and Mitotic Progression.

Cell Reports, 2020
Centrosomes function in key cellular processes ranging from cell division to cellular signaling. Their dysfunction is linked to cancer and developmental disorders. Here, we identify CCDC57 as a pleiotropic regulator of centriole duplication, mitosis, and
H. Kubra Gurkaslar, Efraim Culfa, Melis D Arslanhan, Mariana Lince-Faria, E. N. Firat-Karalar   +4 more
semanticscholar   +1 more source