Results 71 to 80 of about 3,540 (186)
Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Junyan Li +4 more
wiley +1 more source
Nature Communications, 2023 A tight synchrony between the DNA and centrosome cycle is essential for genomic integrity. Centriole disengagement, which licenses centrosomes for duplication, occurs normally during mitotic exit. We recently demonstrated that mild DNA replication stress
Devashish Dwivedi +2 more
doaj +1 more source
Albatross/FBF1 contributes to both centriole duplication and centrosome separation [PDF]
Genes to Cells, 2018 AbstractThe centrosome is a small but important organelle that participates in centriole duplication, spindle formation, and ciliogenesis. Each event is regulated by key enzymatic reactions, but how these processes are integrated remains unknown. Recent studies have reported that ciliogenesis is controlled by distal appendage proteins such as FBF1 ...
Akihito Inoko +7 more
openaire +2 more sources
The FEBS Journal, Volume 293, Issue 2, Page 396-417, January 2026.KDM4A, a chromatin eraser, localizes to the centrosomes. Its demethylase activity is essential for maintaining centrosome number and integrity, independent of gene expression changes. Loss of KDM4A leads to centrosome amplification, pseudo‐bipolar spindle formation, and chromosome segregation errors, including micronuclei and chromatin bridges.
Pratim Chowdhury +16 more
wiley +1 more source
Taking Down the Primary Cilium: Pathways for Disassembly in Differentiating Cells
BioEssays, Volume 47, Issue 11, November 2025.Primary cilia are developmentally essential subcellular signaling compartments. However, many differentiated cells lack primary cilia, and cilia disassembly in these tissue contexts has been largely overlooked. We highlight several pathways for primary cilia loss and examine how changes in ciliation states could contribute to diverse pathologies ...
Carolyn M. Ott, Saikat Mukhopadhyay
wiley +1 more source
When the Clock Is Ticking: The Role of Mitotic Duration in Cell Fate Determination
BioEssays, Volume 47, Issue 11, November 2025.Recently, several studies identified mechanisms by which cells measure mitotic duration and how this influences cell fate, leading to normal cell cycle progression or G1 arrest. In light of drug‐resistant cancer cells that continue proliferating even after mitotic errors, understanding these mechanisms opens the door for new potential therapeutic ...
Cornelia Sala, Elmar Schiebel
wiley +1 more source
Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication.
The Journal of cell biology, 2005 In mammalian cells, the centrosome consists of a pair of centrioles and amorphous pericentriolar material. The pair of centrioles, which are the core components of the centrosome, duplicate once per cell cycle. Centrosomes play a pivotal role in orchestrating the formation of the bipolar spindle during mitosis.
Zou, Chaozhong +6 more
openaire +2 more sources
CPAP insufficiency leads to incomplete centrioles that duplicate but fragment
Journal of Cell Biology, 2022 Centrioles are structures that assemble centrosomes. CPAP is critical for centrosome assembly, and its mutations are found in patients with diseases such as primary microcephaly. CPAP’s centrosomal localization, its dynamics, and the consequences of its insufficiency in human cells are poorly understood.
Alejandra Vásquez-Limeta +7 more
openaire +2 more sources
Revisiting Centrioles in Nematodes—Historic Findings and Current Topics
Cells, 2018 Theodor Boveri is considered as the “father” of centrosome biology. Boveri’s fundamental findings have laid the groundwork for decades of research on centrosomes.
Anna Schwarz +3 more
doaj +1 more source
Eukaryogenesis From FECA to LECA: Radical Steps Along the Way
BioEssays, Volume 47, Issue 11, November 2025.How did the last eukaryotic common ancestor (LECA) population evolve? Recent evidence shows an Asgard archaeon‐like organism acquiring a bacterium, the future mitochondrion, going from symbiosis to endosymbiosis. I postulate that almost all salient LECA characteristics could have resulted from the ensuing enhanced ATP generation and internal reactive ...
Dave Speijer
wiley +1 more source