Results 71 to 80 of about 273,445 (144)

Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication.

The Journal of cell biology, 2005
In mammalian cells, the centrosome consists of a pair of centrioles and amorphous pericentriolar material. The pair of centrioles, which are the core components of the centrosome, duplicate once per cell cycle. Centrosomes play a pivotal role in orchestrating the formation of the bipolar spindle during mitosis.
Zou, Chaozhong, Li, Jun, Bai, Yujie, Gunning, William T., Wazer, David E., Band, Vimla, Gao, Qingshen   +6 more
openaire   +2 more sources

SAK/PLK4 Is Required for Centriole Duplication and Flagella Development [PDF]

Current Biology, 2005
SAK/PLK4 is a distinct member of the polo-like kinase family. SAK-/- mice die during embryogenesis, whereas SAK+/- mice develop liver and lung tumors and SAK+/- MEFs show mitotic abnormalities. However, the mechanism underlying these phenotypes is still not known.Here, we show that downregulation of SAK in Drosophila cells, by mutation or RNAi, leads ...
BETTENCOURT DIAS M., RODRIGUES MARTINS A., CARPENTER L., RIPARBELLI, MARIA GIOVANNA, LEHMANN L., GATT M. K., CARMO N., BALLOUX, CALLAINI, GIULIANO, GLOVER D. M.   +9 more
openaire   +5 more sources

CPAP insufficiency leads to incomplete centrioles that duplicate but fragment

Journal of Cell Biology, 2022
Centrioles are structures that assemble centrosomes. CPAP is critical for centrosome assembly, and its mutations are found in patients with diseases such as primary microcephaly. CPAP’s centrosomal localization, its dynamics, and the consequences of its insufficiency in human cells are poorly understood.
Alejandra Vásquez-Limeta, Kimberly Lukasik, Dong Kong, Catherine Sullenberger, Delgermaa Luvsanjav, Natalie Sahabandu, Raj Chari, Jadranka Loncarek   +7 more
openaire   +2 more sources

Plk4/SAK/ZYG-1 in the regulation of centriole duplication [PDF]

F1000 Biology Reports, 2010
Centrioles organize both centrosomes and cilia. Centriole duplication is tightly regulated and coordinated with the cell cycle to limit duplication to only once per cell cycle. Defects in centriole number and structure are commonly found in cancer. Plk4/SAK and the functionally related Caenorhabditis elegans ZYG-1 kinases initiate centriole duplication.
Pearson, Chad G, Winey, Mark
openaire   +2 more sources

Integrity of the Pericentriolar Material Is Essential for Maintaining Centriole Association during M Phase.

PLoS ONE, 2015
A procentriole is assembled next to the mother centriole during S phase and remains associated until M phase. After functioning as a spindle pole during mitosis, the mother centriole and procentriole are separated at the end of mitosis.
Mi Young Seo, Wonyul Jang, Kunsoo Rhee
doaj   +1 more source

The RAC1 activator Tiam1 regulates centriole duplication through controlling PLK4 levels

bioRxiv, 2020
Centriole duplication is tightly controlled to maintain correct centriole number through the cell cycle. A key component of this control is the regulated degradation of PLK4, the master regulator of centriole duplication.
A. Porter, Gavin R. M. White, Erinn-Lee Ogg, Helen J. Whalley, A. Malliri   +4 more
semanticscholar   +1 more source

Revisiting Centrioles in Nematodes—Historic Findings and Current Topics

Cells, 2018
Theodor Boveri is considered as the “father” of centrosome biology. Boveri’s fundamental findings have laid the groundwork for decades of research on centrosomes.
Anna Schwarz, Prabhu Sankaralingam, Kevin F. O’Connell, Thomas Müller-Reichert   +3 more
doaj   +1 more source

Centrin-2 Is Required for Centriole Duplication in Mammalian Cells [PDF]

Current Biology, 2002
Centrosomes are the favored microtubule-organizing framework of eukaryotic cells. Centrosomes contain a pair of centrioles that normally duplicate once during the cell cycle to give rise to two mitotic spindle poles, each containing one old and one new centriole. However, aside from their role as an anchor point for pericentriolar material and as basal
Salisbury, Jeffrey L, Suino, Kelly M, Busby, Robert, Springett, Margaret   +3 more
openaire   +2 more sources

9-fold symmetry is not essential for centriole elongation and formation of new centriole-like structures

Nature Communications
As daughter centrioles assemble during G2, they recruit conserved Ana3/RTTN followed by its partner Rcd4/PPP1R35. Together, this contributes to the subsequent recruitment of Ana1/CEP295, required for the centriole’s conversion to a centrosome.
Pallavi Panda, Mark S. Ladinsky, David M. Glover   +2 more
doaj   +1 more source

Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly

Nature Communications, 2018
Centriole duplication is tightly regulated in vivo, but the underlying molecular mechanisms are incompletely understood. Here the authors use high-resolution structural and imaging methods to show that CEP85 directly interacts with STIL and mediates ...
Yi Liu, Gagan D. Gupta, Deepak D. Barnabas, Fikret G. Agircan, Shahid Mehmood, Di Wu, Etienne Coyaud, Christopher M. Johnson, Stephen H. McLaughlin, Antonina Andreeva, Stefan M. V. Freund, Carol V. Robinson, Sally W. T. Cheung, Brian Raught, Laurence Pelletier, Mark van Breugel   +15 more
doaj   +1 more source