Results 71 to 80 of about 2,601,570 (295)

Cinacalcet inhibition of neuronal action potentials preferentially targets the fast inactivated state of voltage-gated sodium channels

Frontiers in Physiology, 2022
Voltage-gated sodium channel (VGSC) activation is essential for action potential generation in the brain. Allosteric calcium-sensing receptor (CaSR) agonist, cinacalcet, strongly and ubiquitously inhibits VGSC currents in neocortical neurons via an ...
Jamie S. Lindner, Jamie S. Lindner, Salil R. Rajayer, Salil R. Rajayer, Briana J. Martiszus, Briana J. Martiszus, Stephen M. Smith, Stephen M. Smith   +7 more
doaj   +1 more source

Demonstration of multi-channel 80 Gbit/s integrated transmitter and receiver for wavelength-division multiplexing passive optical network and fronthauling applications [PDF]

, 2016
The performance evaluation of a multi-channel transmitter that employs an arrayed reflective electroabsorption modulator-based photonic integrated circuit and a low-power driver array in conjunction with a multi-channel receiver incorporating a pin ...
Bauwelinck, Johan, Borghesani, A, Cronin, R, Eiselt, M, Grobe, K, Kehayas, E, Lai, CP, Maxwell, G, Naughton, A, Parsons, N, Qiu, Xing-Zhi, Smith, DW, Talli, G, Townsend, PD, Vaernewyck, Renato, Yin, Xin   +15 more
core   +1 more source

Symmetry decomposition of potentials with channels [PDF]

Journal of Physics A: Mathematical and General, 1997
We discuss the symmetry decomposition of the average density of states for the two dimensional potential $V=x^2y^2$ and its three dimensional generalisation $V=x^2y^2+y^2z^2+z^2x^2$. In both problems, the energetically accessible phase space is non-compact due to the existence of infinite channels along the axes.
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Non-localities in nucleon-nucleus potentials

, 2007
Two causes of non-locality inherent in nucleon-nucleus scattering are considered. They are the results of two-nucleon antisymmetry of the projectile with each nucleon in the nucleus and the dynamic polarization potential representation of channel ...
Amos, Amos, Amos, Arellano, Canton, Canton, Cattapan, Cattapan, Cohen, Comfort, Day, Flanz, Funk, G. Pisent, Geramb, Geramb, J. P. Svenne, Jansen, K. Amos, Karataglidis, Kerman, Klug, L. Canton, Machleidt, P. Fraser, Perey, Pisent, S. Karataglidis, Sick, Svenne, Winfield   +30 more
core   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Conotoxins Targeting Neuronal Voltage-Gated Sodium Channel Subtypes: Potential Analgesics?

Toxins, 2012
Voltage-gated sodium channels (VGSC) are the primary mediators of electrical signal amplification and propagation in excitable cells. VGSC subtypes are diverse, with different biophysical and pharmacological properties, and varied tissue distribution ...
Jeffrey R. McArthur, Oliver Knapp, David J. Adams   +2 more
doaj   +1 more source

3-dimensional electrode patterning within a microfluidic channel using metal ion implantation [PDF]

, 2010
The application of electrical fields within a microfluidic channel enables many forms of manipulation necessary for lab-on-a-chip devices. Patterning electrodes inside the microfluidic channel generally requires multi-step optical lithography.
Adleman, James R., Choi, Jae-Woo, Niklaus, Muhamed, Psaltis, Demetri, Rosset, Samuel, Shea, Herbert   +5 more
core   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

CaMKII regulation of cardiac K channels

Frontiers in Pharmacology, 2014
Cardiac K channels are critical determinants of cardiac excitability. In hypertrophied and failing myocardium, alterations in the expression and activity of voltage-gated K currents are frequently observed and contribute to the increased propensity for ...
Julian eMustroph, Lars S Maier, Stefan eWagner   +2 more
doaj   +1 more source