Results 11 to 20 of about 49,554 (304)
CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis.
PLoS ONE, 2014 Pancreatic ductal adenocarcinoma is an unsolved health problem with nearly 75% of patients diagnosed with advanced disease and an overall 5-year survival rate near 5%.
Ishan Roy +5 more
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The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease [PDF]
Frontiers in Physiology, 2014 The chemokine receptor CXCR4 and its ligand CXCL12 play an important homeostatic function by mediating the homing of progenitor cells in the bone marrow and regulating their mobilization into peripheral tissues upon injury or stress. Although the CXCL12/
Yvonne eDöring +3 more
doaj +4 more sources
Interactions of the chemokines CXCL11 and CXCL12 in human tumor cells [PDF]
BMC Cancer, 2022 Abstract Background The chemokines, CXCL12 and CXCL11, are upregulated in tumors from many organs and control their progression. CXCL12 and CXCL11 affect tumor cell functions by either binding their prime receptors, CXCR4 and CXCR3, respectively, and/or CXCR7 as a common second chemokine receptor. In humans, CXCR3 exists
Christian Koch +3 more
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CXC chemokine receptor 4 (CXCR4; NPY3R); chemokine CXC motif ligand 12 (CXCL12; SDF-1) [PDF]
Science-Business eXchange, 2011 openalex +2 more sources
CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression [PDF]
Cancer and Metastasis Reviews, 2010 Chemokines, small pro-inflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors, are major regulators of cell trafficking and adhesion. The chemokine CXCL12 (also called stromal-derived factor-1) is an important α-chemokine that binds primarily to its cognate receptor CXCR4 and thus regulates the ...
Xueqing, Sun +8 more
openaire +2 more sources
Potential of CXCR4/CXCL12 Chemokine Axis in Cancer Drug Delivery [PDF]
Current Pharmacology Reports, 2016 This review discusses the potential of CXCR4 chemokine receptor in the design of anticancer and antimetastatic drug delivery systems. The role of CXCR4 in cancer progression and metastasis is discussed in the context of the development of several types of drug delivery strategies.
Yan Wang, Ying Xie, David Oupický
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Inflammation Controls B Lymphopoiesis by Regulating Chemokine CXCL12 Expression [PDF]
The Journal of Experimental Medicine, 2004 Inflammation removes developing and mature lymphocytes from the bone marrow (BM) and induces the appearance of developing B cells in the spleen. BM granulocyte numbers increase after lymphocyte reductions to support a reactive granulocytosis. Here, we demonstrate that inflammation, acting primarily through tumor necrosis factor α (TNFα), mobilizes BM ...
Ueda, Yoshihiro +4 more
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Monomeric structure of the cardioprotective chemokine SDF‐1/CXCL12 [PDF]
Protein Science, 2009 AbstractThe chemokine stromal cell‐derived factor‐1 (SDF‐1/CXCL12) directs leukocyte migration, stem cell homing, and cancer metastasis through activation of CXCR4, which is also a coreceptor for T‐tropic HIV‐1. Recently, SDF‐1 was shown to play a protective role after myocardial infarction, and the protein is a candidate for development of new anti ...
Christopher T, Veldkamp +8 more
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Small Neutralizing Molecules to Inhibit Actions of the Chemokine CXCL12 [PDF]
Journal of Biological Chemistry, 2008 The chemokine CXCL12 and the receptor CXCR4 play pivotal roles in normal vascular and neuronal development, in inflammatory responses, and in infectious diseases and cancer. For instance, CXCL12 has been shown to mediate human immunodeficiency virus-induced neurotoxicity, proliferative retinopathy and chronic inflammation, whereas its receptor CXCR4 is
Hachet-Haas, Muriel +19 more
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The dimeric form of CXCL12 binds to atypical chemokine receptor 1 [PDF]
Science Signaling, 2021 Biological functions of CXCL12 dimers may be modified by the atypical receptor ACKR1.
Julia C. Gutjahr +10 more
openaire +3 more sources