Results 11 to 20 of about 279,214 (183)

Viral Chemokine Receptors [PDF]

Frontiers in Immunology, 2015
When my lab sequenced the first chemokine receptors CXCR2 and CCR1 in 1991, the top BLAST hit for CCR1 was open reading frame (ORF) US28 of human cytomegalovirus (HCMV), indicating an obvious common ancestor and a possible example of gene piracy. Pox virologists had already identified virally encoded TNF and IFN-γ binding proteins, copied from the host
Philip eMurphy
doaj   +3 more sources

The Role of Atypical Chemokine Receptor CCXCKR (CCRL1) in Human Diseases [PDF]

International Journal of Basic Science in Medicine, 2016
The role of chemokines and their receptors have been identified in many biological activities such as immune response and angiogenesis; however, their regulatory ways are under investigation.
Parvin Salimi, Abolghasem Esmaeili
doaj   +1 more source

On-bead purification and nanodisc reconstitution of human chemokine receptor complexes for structural and biophysical studies

STAR Protocols, 2023
Summary: Chemokine receptors, a subfamily of G-protein-coupled receptors (GPCRs), are responsible for cell migration during physiological processes as well as in diseases like inflammation and cancers.
Siyi Gu, Mian Huang, Tracy M. Handel
doaj   +1 more source

Blocking Chemokine Receptors [PDF]

The Journal of Experimental Medicine, 1997
In our first review on chemokines (([1][1])), we suggested that blockade of the IL-8 receptor or inhibition of IL-8 gene expression could be a new principle for designing antiinflammatory agents. The unexpected growth of the chemokine family and consequent redundancy of the system eventually made ...
M, Baggiolini, B, Moser
openaire   +2 more sources

Accelerated in vivo proliferation of memory phenotype CD4+ T-cells in human HIV-1 infection irrespective of viral chemokine co-receptor tropism. [PDF]

, 2013
CD4(+) T-cell loss is the hallmark of HIV-1 infection. CD4 counts fall more rapidly in advanced disease when CCR5-tropic viral strains tend to be replaced by X4-tropic viruses.
A Kaur, A Llano, A Yates, AN Phillips, Andrea Hegedus, Andrew Worth, B Asquith, Catherine de Lara, D Berhanu, Daniel C. Douek, DC Douek, DC Douek, DC Macallan, DC Macallan, DC Macallan, DC Macallan, DD Ho, Derek Macallan, DL Wallace, EJ Heeregrave, HC Lane, I den Braber, J Embretson, JM Brenchley, JM McCune, JV Giorgi, K Ladell, Karoliina Laamanen, L Cicin-Sain, LJ Picker, M Catalfamo, M Hellerstein, M Koot, MD Hazenberg, MK Hellerstein, MP Davenport, N Brieu, N Vrisekoop, Peter Beverley, R Busch, R Shankarappa, RJ De Boer, RJ De Boer, RM Ribeiro, RM Ribeiro, RS Veazey, SA Handley, TW Chun, V Sanchez, Yan Zhang   +49 more
core   +9 more sources

Questions about Chemokine and Chemokine Receptor Antagonism in Renal Inflammation [PDF]

, 2010
Chemokines remain attractive therapeutic targets for modulating inflammatory diseases in all areas of medicine including acute and chronic kidney disease.
Anders, Hans-Joachim, Sayyed, Sufyan Ali, Vielhauer, Volker   +2 more
core   +1 more source

A Scintillation Proximity Assay for Real-Time Kinetic Analysis of Chemokine–Chemokine Receptor Interactions

Cells, 2022
Chemokine receptors are extensively involved in a broad range of physiological and pathological processes, making them attractive drug targets. However, despite considerable efforts, there are very few approved drugs targeting this class of seven ...
Stefanie Alexandra Eberle, Martin Gustavsson   +1 more
doaj   +1 more source

A guide to chemokines and their receptors [PDF]

, 2018
The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G‐protein coupled heptahelical chemokine receptors.
Braun A, Dyer DP, Garton KJ, Gupta SK, Hundelshausen P, Janssens R, Murphy PM, Sozzani S, Speck RF, Suan D, Woollard SM, Zheng Y   +11 more
core   +1 more source

CHEMOKINE RECEPTORS [PDF]

Biomedical Papers, 2000
Chemokines mediate their multiple effects by binding to a variety of specific receptors, that comprise a subfamily of rhodopsin-like, 7-transmembrane domain receptors, coupled to G proteins. Some of these receptors serve as coreceptors for HIV, some of them could be expressed as markers for T lymphocyte functional differentiation.
openaire   +2 more sources

Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system. [PDF]

, 2006
Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection.
A. Meyer, A.A. Dandekar, A.D. Luster, B. Mehrad, B. Parra, B. Parra, B.D. Pearce, B.P. Chen, B.T. Fife, C. Gerard, C. Ramakrishna, C. Ramakrishna, C.A. Biron, C.E. Patterson, C.J. Raport, C.M. Hogaboam, D. Franciotta, D. Galimberti, D. Whiting, D.D. Taub, D.J. Mahad, D.M. Muller, D.N. Cook, D.P. Widney, E. Lazzeri, E.J. McMahon, F.R. Fischer, F.S. Cheever, G. Penna, G. Penna, G.B. Huffnagle, G.C. Hildebrandt, G.F. Wu, H. Bartosik-Psujek, H.G. Fischer, H.G. Fischer, I. Banisor, I. Clark-Lewis, I. Salomon, I. Tsunoda, I.E. Flesch, J. Gosling, J.B. Domachowske, J.C. Houck, J.F. Bazan, J.H. Dufour, J.H. Xie, J.J. Phillips, J.M. Farber, J.S. Haring, J.S. Haring, J.S. Williamson, J.S. Williamson, K. Holmes, K. McIntosh, K.E. Balashov, K.S. Held, K.S. Warmington, K.V. Holmes, L. Boring, L. Boring, L. Cartier, L. Gu, L. Gu, L. Pewe, L. Pewe, M. Baggiolini, M. Greter, M. Matsui, M.A. Olszewski, M.J. Buchmeier, M.J. Trifilo, M.J. Trifilo, M.J. Trifilo, M.M. Lai, M.T. Lin, M.T. Lin, M.T. Liu, M.T. Liu, M.T. Liu, N. Sato, N.J. Megjugorac, N.W. Marten, R. Gade-Andavolu, R. Watanabe, R.F. Castro, R.S. Klein, S. Narumi, S. Qin, S. Xue, S.A. Stohlman, S.A. Stohlman, S.D. Miller, S.M. Stamatovic, S.R. Perlman, T.E. Lane, T.E. Lane, T.E. Lane, T.L. Sorensen, T.L. Sorensen, T.S. Kim, T.S. Kim, W.G. Glass, W.G. Glass, W.G. Glass, W.G. Glass, W.J. Karpus, Y. Zhang, Y. Zhou   +108 more
core   +1 more source