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Chromatin Remodeling in VSMC Phenotype Switching During Vascular Remodeling: From Mechanism to Therapeutic Potential [PDF]
BiomoleculesVascular remodeling is a characteristic pathological feature of various vascular diseases, including atherosclerosis, restenosis following vascular injury, hypertension, and aneurysms. The phenotypic switching of vascular smooth muscle cells (VSMCs) acts
Xiaozhu Ma +5 more
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Chromatin remodeling in oligodendrogenesis
Вавиловский журнал генетики и селекции, 2021 Oligodendrocytes are one type of glial cells responsible for myelination and providing trophic support for axons in the central nervous system of vertebrates.
E. V. Antontseva, N. P. Bondar
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Chromatin remodeling complexes: architects influencing breast cancer progression [PDF]
Frontiers in Cell and Developmental BiologyAs one of the most common types of cancer, breast cancer strongly contributes to the increase in morbidity and mortality worldwide. Alterations in the genetic and epigenetic landscape contribute to the complexity and heterogeneity of the disease, making ...
Octavianus Giovani +3 more
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Tracking DNA damage localization and chromatin remodeling in live cells using time-resolved quantitative analysis of DNA counterstains [PDF]
Cellular and Molecular Life SciencesDNA damage profoundly impacts genome stability and cellular homeostasis, and its repair is tightly coordinated with local chromatin remodeling. However, monitoring these rapid chromatin changes in living cells remains challenging.
Greta Paternò +2 more
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Frontiers in Cellular and Infection Microbiology, 2022 Intracellular pathogens manipulate the host cell for their own survival by contributing to modifications of host epigenome, and thus, altering expression of genes involved in the pathogenesis.
Harsimran Kaur Brar +5 more
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Biomedicines, 2023 Cardiovascular diseases are a major cause of death globally, with no cure to date. Many interventions have been studied and suggested, of which epigenetics and chromatin remodeling have been the most promising.
Lindsay Kraus, Brianna Beavens
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The chromatin remodeler SPLAYED regulates specific stress signaling pathways. [PDF]
PLoS Pathogens, 2008 Organisms are continuously exposed to a myriad of environmental stresses. Central to an organism's survival is the ability to mount a robust transcriptional response to the imposed stress. An emerging mechanism of transcriptional control involves dynamic
Justin W Walley +6 more
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Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration
Cell & Bioscience, 2023 The dynamic changes in chromatin conformation alter the organization and structure of the genome and further regulate gene transcription. Basically, the chromatin structure is controlled by reversible, enzyme-catalyzed covalent modifications to chromatin
Dongfang Jiang +4 more
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Knockdown of DOM/Tip60 Complex Subunits Impairs Male Meiosis of Drosophila melanogaster
Cells, 2023 ATP-dependent chromatin remodeling complexes are involved in nucleosome sliding and eviction and/or the incorporation of histone variants into chromatin to facilitate several cellular and biological processes, including DNA transcription, replication and
Yuri Prozzillo +5 more
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Sodium Valproate-Induced Chromatin Remodeling
Frontiers in Cell and Developmental Biology, 2021 Valproic acid/sodium valproate (VPA), a drug originally prescribed as an anticonvulsant, has been widely reported to act on epigenetic marks by inducing histone acetylation, affecting the DNA and histone methylation status, and altering the expression of
Maria Luiza S. Mello
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