Results 1 to 10 of about 539,283 (308)
Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration
Cell & Bioscience, 2023 The dynamic changes in chromatin conformation alter the organization and structure of the genome and further regulate gene transcription. Basically, the chromatin structure is controlled by reversible, enzyme-catalyzed covalent modifications to chromatin
Dongfang Jiang +4 more
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Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement [PDF]
eLife, 2019 Eukaryotic DNA is packaged into nucleosome arrays, which are repositioned by chromatin remodeling complexes to control DNA accessibility. The Saccharomyces cerevisiae RSC (Remodeling the Structure of Chromatin) complex, a member of the SWI/SNF chromatin ...
Avinash B Patel +6 more
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Targeting Chromatin-Remodeling Factors in Cancer Cells: Promising Molecules in Cancer Therapy
International Journal of Molecular Sciences, 2022 ATP-dependent chromatin-remodeling complexes can reorganize and remodel chromatin and thereby act as important regulator in various cellular processes.
Fang-Lin Zhang, Da-Qiang Li
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Frontiers in Cellular and Infection Microbiology, 2022 Intracellular pathogens manipulate the host cell for their own survival by contributing to modifications of host epigenome, and thus, altering expression of genes involved in the pathogenesis.
Harsimran Kaur Brar +5 more
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Biophysics of Chromatin Remodeling.
Annual Review of Biophysics, 2021 As primary carriers of epigenetic information and gatekeepers of genomic DNA, nucleosomes are essential for proper growth and development of all eukaryotic cells.
I. Nodelman, G. Bowman
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Biomedicines, 2023 Cardiovascular diseases are a major cause of death globally, with no cure to date. Many interventions have been studied and suggested, of which epigenetics and chromatin remodeling have been the most promising.
Lindsay Kraus, Brianna Beavens
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The chromatin remodeler SPLAYED regulates specific stress signaling pathways. [PDF]
PLoS Pathogens, 2008 Organisms are continuously exposed to a myriad of environmental stresses. Central to an organism's survival is the ability to mount a robust transcriptional response to the imposed stress. An emerging mechanism of transcriptional control involves dynamic
Justin W Walley +6 more
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Knockdown of DOM/Tip60 Complex Subunits Impairs Male Meiosis of Drosophila melanogaster
Cells, 2023 ATP-dependent chromatin remodeling complexes are involved in nucleosome sliding and eviction and/or the incorporation of histone variants into chromatin to facilitate several cellular and biological processes, including DNA transcription, replication and
Yuri Prozzillo +5 more
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Definitions, 2020 Chromatin Remodeling involves alterations of the content or activity of DNA-binding and chromatin-associated proteins that affect the function and higher order conformational state of chromatin, as well as the activity of specific genes or functional DNA
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Sodium Valproate-Induced Chromatin Remodeling
Frontiers in Cell and Developmental Biology, 2021 Valproic acid/sodium valproate (VPA), a drug originally prescribed as an anticonvulsant, has been widely reported to act on epigenetic marks by inducing histone acetylation, affecting the DNA and histone methylation status, and altering the expression of
Maria Luiza S. Mello
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