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Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration
Cell & Bioscience, 2023 The dynamic changes in chromatin conformation alter the organization and structure of the genome and further regulate gene transcription. Basically, the chromatin structure is controlled by reversible, enzyme-catalyzed covalent modifications to chromatin
Dongfang Jiang +4 more
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Definitions, 2020 Chromatin Remodeling involves alterations of the content or activity of DNA-binding and chromatin-associated proteins that affect the function and higher order conformational state of chromatin, as well as the activity of specific genes or functional DNA
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β-actin dependent chromatin remodeling mediates compartment level changes in 3D genome architecture [PDF]
Nature Communications, 2021 β-actin is a crucial component of several chromatin remodeling complexes that control chromatin structure and accessibility. The mammalian Brahma-associated factor (BAF) is one such complex that plays essential roles in development and differentiation by
Syed Raza Mahmood +5 more
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Biophysics of Chromatin Remodeling.
Annual Review of Biophysics, 2021 As primary carriers of epigenetic information and gatekeepers of genomic DNA, nucleosomes are essential for proper growth and development of all eukaryotic cells.
I. Nodelman, G. Bowman
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Chromatin remodeling in oligodendrogenesis
Вавиловский журнал генетики и селекции, 2021 Oligodendrocytes are one type of glial cells responsible for myelination and providing trophic support for axons in the central nervous system of vertebrates.
E. V. Antontseva, N. P. Bondar
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Chromatin remodeling complexes: architects influencing breast cancer progression [PDF]
Frontiers in Cell and Developmental BiologyAs one of the most common types of cancer, breast cancer strongly contributes to the increase in morbidity and mortality worldwide. Alterations in the genetic and epigenetic landscape contribute to the complexity and heterogeneity of the disease, making ...
Octavianus Giovani +3 more
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Dietary polyphenols and chromatin remodeling
Critical Reviews in Food Science and Nutrition, 2017 Polyphenols are the most abundant phytochemicals in fruits, vegetables, and plant-derived beverages. Recent findings suggest that polyphenols display the ability to reverse adverse epigenetic regulation involved in pathological conditions, such as obesity, metabolic disorder, cardiovascular and neurodegenerative diseases, and various forms of cancer ...
G. Russo +5 more
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Frontiers in Cellular and Infection Microbiology, 2022 Intracellular pathogens manipulate the host cell for their own survival by contributing to modifications of host epigenome, and thus, altering expression of genes involved in the pathogenesis.
Harsimran Kaur Brar +5 more
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Targeting Chromatin-Remodeling Factors in Cancer Cells: Promising Molecules in Cancer Therapy
International Journal of Molecular Sciences, 2022 ATP-dependent chromatin-remodeling complexes can reorganize and remodel chromatin and thereby act as important regulator in various cellular processes.
Fang-Lin Zhang, Da-Qiang Li
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PARP1: Liaison of Chromatin Remodeling and Transcription
Cancers, 2022 Simple Summary Poly(ADP-ribose) polymerase 1 (PARP1) is perhaps the most studied member of the PARP superfamily and participates in numerous cellular processes.
Wen Zong +4 more
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