Results 101 to 110 of about 45,661 (289)

CircPVT1 Promotes Lung Metastasis and Tumor Progression in Renal Cell Carcinoma by Encoding the cP104aa Peptide and Targeting EIF4A3

Advanced Science, EarlyView.
This study reveals that circPVT1 promotes the renal cell carcinoma lung metastasis and tumor progression through encoding the cP104aa peptide and directly binds with EIF4A3, which jointly regulates the target gene c‐MYC. Abstract Circular RNA (circRNA) plays a pivotal role in the pathogenesis of renal cell carcinoma (RCC).
Houliang Zhang, Tao Tao, Jie Ji, Tonglei Zhao, Si Sun, Lijie Zhang, Jianping Wu, Ming Chen, Shuqiu Chen, Bin Xu, Weipu Mao   +10 more
wiley   +1 more source

CircRNA inhibits DNA damage repair by interacting with host gene

Molecular Cancer, 2020
Deregulated circular RNAs (circRNAs) are associated with the development of cancer and therapy resistance. However, functional research of circRNAs mostly focus on potential miRNA or protein binding and more potential regulation of circRNA on host gene ...
Xiaolong Xu, Jingwei Zhang, Yihao Tian, Yang Gao, Xin Dong, Wenbo Chen, Xiaoning Yuan, Weinan Yin, Jinjing Xu, Ke Chen, Chunjiang He, Lei Wei   +11 more
semanticscholar   +1 more source

m6A‐Modified circRAPGEF1 Interaction with IGF2BP3 Promotes Hepatocellular Carcinoma Progression via Reprogramming Aspartate Metabolism

Advanced Science, EarlyView.
In hepatocellular carcinoma (HCC), the m6A‐modified circRAPGEF1 destabilizes ASS1 mRNA via competitive binding to IGF2BP3, driving aspartate metabolic reprogramming in liver cancer stem cells (LCSCs). This cascade enhances stemness properties and reduces sorafenib sensitivity in LCSCs, thereby identifying circRAPGEF1 as a promising therapeutic target ...
Juanyi Shi, Sintim Mui, Yongcong Yan, Shaomin Liu, Kai Wen, Chuanchao He, Huoming Li, Hao Liao, Meng Tao, Jiahua Wen, Weidong Wang, Xiaoding Xu, Zhenyu Zhou, Zhiyu Xiao   +13 more
wiley   +1 more source

A unified mechanism for intron and exon definition and back-splicing. [PDF]

, 2019
The molecular mechanisms of exon definition and back-splicing are fundamental unanswered questions in pre-mRNA splicing. Here we report cryo-electron microscopy structures of the yeast spliceosomal E complex assembled on introns, providing a view of the ...
Cui, Yanxiang, Das, Rhiju, Espinosa, Sara, Hansen, Kirk C, Hill, Ryan C, Issaian, Aaron, Kappel, Kalli, Li, Xueni, Liu, Shiheng, Shi, Shasha, Zhang, Lingdi, Zhao, Rui, Zhou, Z Hong   +12 more
core  

Functional relevance of circRNA aberrant expression in pediatric acute leukemia with KMT2A::AFF1 fusion [PDF]

, 2023
: Circular RNAs (circRNAs) are emerging molecular players in leukemogenesis and promising therapeutic targets. In KMT2A::AFF1 (MLL::AF4)-rearranged leukemia, an aggressive disease compared with other pediatric B-cell precursor (BCP) acute lymphoblastic ...
Biondi, Andrea, Boldrin, Elena, Bortoluzzi, Stefania, Bresolin, Silvia, Buldini, Barbara, Buratin, Alessia, Cani, Alice, Cazzaniga, Giovanni, Gaffo, Enrico, Guglielmelli, Paola, Locatelli, Franco, Longo, Giorgia, Meyer, Lueder H, Molin, Anna Dal, Serafin, Valentina, Te Kronnie, Geertruij, Tretti Parenzan, Caterina, Vannucchi, Alessandro M   +17 more
core   +1 more source

Single‐Droplet Dual‐Target Quantification of circRNA Biomarkers for Colorectal Cancer Screening

Advanced Science, EarlyView.
Circular RNAs are crucial in tumorigenesis. This study identifies circCK1γ3 and circWDR37 as dual plasma biomarkers for colorectal cancer (CRC) screening. It is developed Casµchip, a droplet microfluidic chip using Cas13a/b technology to quantify these biomarkers.
Jingsong Xu, Yu Liu, Junheng Zhang, Shuang Yang, Tianming Li, Haiqian Huang, Qian Liu, Hengliang Wang, Li Cao, Zhenghua An, Min Li, Hua Wang   +11 more
wiley   +1 more source

An observation of circular RNAs in bacterial RNA-seq data [PDF]

, 2016
Circular RNAs (circRNAs) are a class of RNA with an important role in micro RNA (miRNA) regulation recently discovered in Human and various other eukaryotes as well as in archaea.
Aurell, Erik, d'hérouël, Aymeric Fouquier, Innocenti, Nicolas, Nguyen, Hoang-Son   +3 more
core   +1 more source

Association of microRNA-7 and its binding partner CDR1-AS with the prognosis and prediction of 1st-line tamoxifen therapy in breast cancer [PDF]

, 2018
The large number of non-coding RNAs (ncRNAs) and their breadth of functionalities has fuelled many studies on their roles in cancer. We previously linked four microRNAs to breast cancer prognosis.
Foekens, J.A. (John), Hammerl, D.M. (Dora), Martens, J.W.M. (John), Sieuwerts, A.M. (Anieta), Smid, M. (Marcel), Uhr, K. (Katharina), Weerd, V. (Vanja) de   +6 more
core   +2 more sources

N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling

Molecular Cancer, 2020
Background and aims Accumulating evidence suggests that the primary and acquired resistance of hepatocellular carcinoma (HCC) to sorafenib is mediated by multiple molecular, cellular, and microenvironmental mechanisms. Understanding these mechanisms will
Junjie Xu, Zhe Wan, M. Tang, Zhongjie Lin, Shi Jiang, Lin Ji, Kirill Gorshkov, Qijiang Mao, Shun-jie Xia, D. Cen, Junhao Zheng, X. Liang, Xiujun Cai   +12 more
semanticscholar   +1 more source

circRNA-0006896-miR1264-DNMT1 axis plays an important role in carotid plaque destabilization by regulating the behavior of endothelial cells in atherosclerosis

Molecular Medicine Reports, 2021
Atherosclerosis (AS) is a chronic inflammatory disease of the vascular wall with multiple causes. AS is the primary pathological basis of cardiovascular disease and stroke.
Y. Wen, Y. Chun, Zhong Lian, Zhang Yong, Yang Mei Lan, Liao Huan, Chen Yi Xi, Li Shu Juan, Zhong Wen Qing, Cheng Jia, Zhang Huan Ji   +10 more
semanticscholar   +1 more source