Results 101 to 110 of about 52,173 (326)

CircRNA: functions and properties of a novel potential biomarker for cancer

Molecular Cancer, 2017
Circular RNAs, a novel class of endogenous noncoding RNAs, are characterized by their covalently closed loop structures without a 5′ cap or a 3′ Poly A tail.
Shujuan Meng, Hecheng Zhou, Ziyang Feng, Zihao Xu, Ying Tang, Peiyao Li, Minghua Wu   +6 more
semanticscholar   +1 more source

CircRNA inhibits DNA damage repair by interacting with host gene

Molecular Cancer, 2020
Deregulated circular RNAs (circRNAs) are associated with the development of cancer and therapy resistance. However, functional research of circRNAs mostly focus on potential miRNA or protein binding and more potential regulation of circRNA on host gene ...
Xiaolong Xu, Jingwei Zhang, Yihao Tian, Yang Gao, Xin Dong, Wenbo Chen, Xiaoning Yuan, Weinan Yin, Jinjing Xu, Ke Chen, Chunjiang He, Lei Wei   +11 more
semanticscholar   +1 more source

The RNA-binding protein SFPQ preserves long-intron splicing and regulates circRNA biogenesis in mammals

eLife, 2021
Circular RNAs (circRNAs) represent an abundant and conserved entity of non-coding RNAs; however, the principles of biogenesis are currently not fully understood.
L. V. W. Stagsted, E. O'Leary, K. K. Ebbesen, T. B. Hansen   +3 more
semanticscholar   +1 more source

The Evolutionarily Conserved TPM1 Super‐Enhancer Drives Skeletal Muscle Regeneration via Mechanotransduction Signaling

Advanced Science, EarlyView.
By integrating biomechanical and epigenetic cues, the evolutionarily conserved TPM1 super‐enhancer drives myogenesis via TEAD4‐mediated chromatin looping. This mechanism produces species‐specific outputs (linear TPM1 mRNA in mice and CircTPM1 in bovine) that activate PI3K/AKT mechanotransduction and the MYH10/MYL3 axis to execute cytoskeletal ...
Ruimen Zhang, Wanyou Feng, Yanyan Yang, Yu Pan, Chaoxia Zou, Leyi Wang, Sanbao Zhang, Yimin Zhao, Yongmei Wu, Jinling Wang, Jianwei Zou, Kehe Cen, Yongwang Zhang, Han Huang, Yurong Xu, Li Zhong, Hailong Gong, Juanru Cheng, Jingyuan Liang, Zihua Zheng, Qinyang Jiang, Jingwei Wei, Hui Li, Minhui Liang, Deshun Shi, Sufang Yang, Yanfei Deng, Yingming Wei   +27 more
wiley   +1 more source

CircPrimer: a software for annotating circRNAs and determining the specificity of circRNA primers [PDF]

BMC Bioinformatics, 2018
Since circular RNAs (circRNAs) post-transcriptionally regulate gene expression, they have attracted increasing attention. However, there is no existing tool to annotate and extract spliced sequences for circRNAs and no tool to determine the specificity of circRNA primers.In this study, we present circPrimer, which allows users to search, annotate, and ...
Shanliang Zhong, Jinyan Wang, Qian Zhang, Hanzi Xu, Jifeng Feng   +4 more
openaire   +3 more sources

CircPrimer 2.0: a software for annotating circRNAs and predicting translation potential of circRNAs

BMC Bioinformatics, 2022
Abstract Background Some circular RNAs (circRNAs) can be translated into functional peptides by small open reading frames (ORFs) in a cap-independent manner. Internal ribosomal entry site (IRES) and N6-methyladenosine (m6A) were reported to drive translation of circRNAs.
Shanliang Zhong, Jifeng Feng
openaire   +3 more sources

Mechanisms of non-coding RNA-modulated alternative splicing in cancer

RNA Biology, 2022
Alternative splicing (AS) is a common and pivotal process for eukaryotic gene expression regulation, which enables a precursor RNA to produce multiple transcript variants with diverse cellular functions.
Xiaolin Wang, Jinghan Hua, Jingxin Li, Jiahui Zhang, Emmanuel Enoch Dzakah, Guozhen Cao, Wenchu Lin   +6 more
doaj   +1 more source

Effect of circular RNA hsa_circ_0000231 interacting with HnRNPK on proliferation, migration, and apoptosis in breast cancer

陆军军医大学学报, 2022
Objective To explore the effects of the interaction between circular RNA hsa_circ_0000231 and HnRNPK on the proliferation, migration and apoptosis in breast cancer. Methods Microarray analysis was used to investigate the expression profile of circRNAs in
HU Mengting, CHEN Junxia
doaj   +1 more source

Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression

Molecular Cancer, 2020
Although both circular RNAs (circRNAs) and autophagy are associated with the function of breast cancer (BC), whether circRNAs regulate BC progression via autophagy remains unknown.
G. Liang, Y. Ling, M. Mehrpour, P. Saw, Zihao Liu, W. Tan, Z. Tian, W. Zhong, Wanyi Lin, Qing Luo, Qun Lin, Qiufang Li, You Zhou, Ahmed Hamai, P. Codogno, Jun Li, E. Song, C. Gong   +17 more
semanticscholar   +1 more source

Droplet Digital CRISPR for Nucleic Acid Detection

Advanced Science, EarlyView.
This review outlines recent advances in droplet digital CRISPR technology for nucleic acid detection, combining CRISPR specificity with droplet digital‐based absolute quantification. It summarizes core principles, amplification‐assisted and amplification‐free strategies, and representative DNA and RNA biomarker applications.
Yang Zhang, Roy S. K. Walker, Anwar Sunna, Tracie J. Barber, Ming Li   +4 more
wiley   +1 more source