Results 111 to 120 of about 45,661 (289)

SenExo‐cCCT2 Reprograms Senescence Response and Anti‐Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
This study demonstrates that SenExo‐cCCT2 enables targeted delivery of cCCT2 to pancreatic cancer cells, where it disrupts IPO13‐mediated nuclear translocation of UBC9, impairing SUMOylation‐dependent DNA damage repair and inducing senescence. Senescent tumor cells secrete CXCL10 to recruit CD8⁺ T‐cells while upregulating PD‐L1.
Shuncang Zhu, Yinhao Chen, Hongyi Lin, Jinpeng Lu, Yu Pan, Ge Li, Yongding Wu, Haoxiang Zhang, Xiaoxiao Huang, Yiting Chen, Huangjing Chen, Long Jin, Min Huang, Chengyu Liao, Long Huang, Yifeng Tian, Zuwei Wang, Qiaowei Li, Shi Chen   +18 more
wiley   +1 more source

Roles of circRNAs in hematological malignancies

Biomarker Research, 2022
AbstractAs one of the leading causes of death, hematologic malignancies are associated with an ever-increasing incidence, and drug resistance and relapse of patients after treatment represent clinical challenges. Therefore, there are pressing demands to uncover biomarkers to indicate the development, progression, and therapeutic targets for hematologic
Fahua Deng, Chengsi Zhang, Tingting Lu, Ezhong Joshua Liao, Hai Huang, Sixi Wei   +5 more
openaire   +3 more sources

PCDA-HNMP: Predicting circRNA-disease association using heterogeneous network and meta-path

Mathematical Biosciences and Engineering, 2023
Increasing amounts of experimental studies have shown that circular RNAs (circRNAs) play important regulatory roles in human diseases through interactions with related microRNAs (miRNAs).
Lei Chen, Xiaoyu Zhao
doaj   +1 more source

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations. [PDF]

, 2019
Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and without Alzheimer disease (AD; ncontrol = 13; nAD = 83) from the Knight Alzheimer Disease Research Center (Knight ADRC).
Bateman, Randall J, Budde, John P, Chhatwal, Jasmeer P, Cruchaga, Carlos, Del-Aguila, Jorge L, Dominantly Inherited Alzheimer Network (DIAN), Dube, Umber, Farias, Fabiana, Fernandez, Maria Victoria, Gentsch, Jen, Graff-Radford, Neill R, Harari, Oscar, Hsu, Simon, Ibanez, Laura, Jiang, Shan, Karch, Celeste M, Lee, Jae-Hong, Li, Zeran, Masters, Colin L, Morris, John C, Norton, Joanne, Salloway, Stephen, Wang, Fengxian   +22 more
core  

Identification of miRNA signatures associated with radiation-induced late lung injury in mice. [PDF]

, 2020
Acute radiation exposure of the thorax can lead to late serious, and even life-threatening, pulmonary and cardiac damage. Sporadic in nature, late complications tend to be difficult to predict, which prompted this investigation into identifying non ...
Iwamoto, Keisuke S, Lee, Jason T, Lukaszewicz, Agnes I, McBride, William H, Menon, Naresh, Micewicz, Ewa D, Miller, Thomas A, Nguyen, Christine, Olafsen, Tove, Ratikan, Josephine A, Rogers, Claude J, Schaue, Dörthe, Starbird, Mark A, Yamada-Hanff, Jason   +13 more
core   +1 more source

Circbank: a comprehensive database for circRNA with standard nomenclature

RNA Biology, 2019
Circular RNAs (circRNAs) represent a new type of regulatory RNA which forms a covalently closed continuous loop from back-splicing events, a process in which the downstream 5′ splice site and the 3′ splice site are covalently linked.
Ming Liu, Qian Wang, Jian Shen, Burton B. Yang, Xiangming Ding   +4 more
semanticscholar   +1 more source

Hsa_circ_0026782 Acts as a “Molecular Break” of CREB1‐Mediated Transcription by Promoting Its Phosphorylation at Ser142 That Prevents Keloid Progression

Advanced Science, EarlyView.
Model for the role of hsa_circ_0026782/p‐CREB1 (Ser142) played in keloid. Hsa_circ_0026782 is derived from back‐splicing of ITGA7 exon 4. When hsa_circ_0026782 binds to CREB1, the exposure of the bZIP domain and dimerization of CREB1 are promoted (upper left).
Xin‐Cao Zhong, Chun‐Ye Chen, Zi‐Xuan Feng, Yong Wang, Tao Zhang, Ze‐Ming Zhuang, Zhang‐Rui Wu, Yong‐Zhong Du, Jun Chen, Xiao‐Ying Lin, Wei‐Qiang Tan   +10 more
wiley   +1 more source

Circ_0001686 Promotes Prostate Cancer Progression by Up-Regulating SMAD3/TGFBR2 via miR-411-5p

The World Journal of Men's Health, 2022
Purpose: As the mechanism of interaction between circular RNAs (circRNAs) and microRNAs (miRNAs) in regulating the development of prostate cancer (PCa) is not clear, this study focuses on investigating these effects.
Jiancheng Pan, Zihao Liu, Zhizhao Yang, Enli Liang, Cheng Fang, Dingrong Zhang, Xiaodong Zhou, Yuanjie Niu, Zhongcheng Xin, Yegang Chen, Qiliang Cai   +10 more
doaj   +1 more source

A study of differential circRNA and lncRNA expressions in COVID-19-infected peripheral blood

Scientific Reports, 2021
To conquer the worldwide outbreak of COVID-19 virus, a large number of studies have been carried out on COVID-19 infection, transmission and treatment. However, few studies have been conducted from the perspectives of circRNA and lncRNA, which are known ...
Yingping Wu, T. Zhao, R. Deng, Xiaoping Xia, Bin Li, Xunzhang Wang   +5 more
semanticscholar   +1 more source

Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities

Advanced Science, EarlyView.
Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil, Josh J. Friesen, Nuthan V. Bathula, Anneke Strumpel, Chia Hao Ho, Ilana Guez, Kristen Y. S. Kong, Andrew J. Varley, Shigeki J. Miyake‐Stoner, Parinaz Aliahmad, Nathaniel S. Wang, Andrew J. Geall, Anna K. Blakney   +12 more
wiley   +1 more source