Results 151 to 160 of about 45,661 (289)

Colorectal cancer: from the genetic model to posttranscriptional regulation by noncoding RNAs [PDF]

, 2017
Colorectal cancer is the third most common form of cancer in developed countries and, despite the improvements achieved in its treatment options, remains as one of the main causes of cancer-related death.
Calle Espinosa, Jorge, Fernández Lizarbe, Eva, Fernández Lizarbe, Sara, Lizarbe, María Antonia, Olmo López, Nieves, Robles, Miguel Ángel, Turnay, Javier   +6 more
core   +4 more sources

Invention of circRNA promoting RNA to specifically promote circRNA production

Nucleic Acids Research
Abstract CircRNA, an essential RNA molecule involved in various biological functions and diseases, often exhibits decreased expression in tumor tissues, playing a role as a tumor suppressor, and suggesting therapeutic potential for cancer. However, current methods for promoting circRNA production are limited.
Zhilin He, Haofei Ji, Bei Xia, Xiuen Cao, Ying Huang, Qubo Zhu   +5 more
openaire   +2 more sources

Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA. [PDF]

, 2017
Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated.
An, Andersson, Augoff, Bartel, Beermann, Broadbent, Cai, Calin, Carrieri, Chen, Chu, Cloonan, Costanza Emanueli, de Hoon, de Pontual, Diederichs, Djebali, Elton, Gabory, Gabory, Gao, Geisler, Gong, Gonzalez, Guttman, Hangauer, Hansen, Hansen, Hindorff, Iain M. Dykes, Imig, Ishii, Johnson, Johnsson, Kallen, Kampa, Kapranov, Kapranov, Kasar, Keniry, Khalil, Kim, Kim, Kim, Kino, Kretz, Krumlauf, Kumar, Lai, Lam, Lee, Leppek, Lerner, Li, Li, Li, Li, Luco, Malik, Mattick, Memczak, Mercer, Milligan, Monnier, Morenos, Mousavi, Nagano, Nagano, Novikova, Ong, Orom, Orom, Palazzo, Pandey, Papanayotou, Park, Pastori, Pegueroles, Poliseno, Rinn, Rinn, Rinn, Ripoche, Rutnam, Saini, Salmena, Salzman, Salzman, Sarma, Seitz, Siomi, Slezak-Prochazka, Smith, Somarowthu, Sotelo, Srisawat, St Laurent, Tam, Thomas, Thomson, Tripathi, Tsai, Underwood, Wan, Wang, Wang, Wang, Winter, Xiang, Yang, Yoon, Zemel, Zeng   +112 more
core   +4 more sources

Large-scale benchmarking of circRNA detection tools reveals large differences in sensitivity but not in precision

bioRxiv, 2023
Marieke Vromman, J. Anckaert, S. Bortoluzzi, Alessia Buratin, Chia-Ying Chen, Qinjie Chu, Trees-Juen Chuang, Roozbeh Dehghannasiri, C. Dieterich, Xin Dong, P. Flicek, Enrico Gaffo, W. Gu, Chunjiang He, Steve Hoffmann, Osagie G. Izuogu, M. Jackson, Tobias Jakobi, E. Lai, J. Nuytens, J. Salzman, M. Santibanez-Koref, P. Stadler, O. Thas, E. V. Eynde, K. Verniers, Guoxia Wen, J. Westholm, Li Yang, Chuyu Ye, N. Yigit, Guoliang Yuan, Jinyang Zhang, F. Zhao, J. Vandesompele, P. Volders   +35 more
semanticscholar   +1 more source

Autophagy‐Targeting Nanomedicine: Strike at the Heart of the Cancer via Precise Modulation of Autophagy

Exploration, EarlyView.
This review emphasizes the critical role of autophagy in cancer treatment, highlighting the development of autophagy‐targeting nanomedicines and their applications in combination therapies. It explores how nanoplatforms can effectively regulate autophagy, underscoring the potential of integrating autophagy modulation with other treatment strategies to ...
Zhouyi Sun, Huali Zuo, Kai Zhang, Yang Liu, Qianwen Wang, Qitao Hu, Jiwei Qian, Andreas Lundqvist, Bo Zhang, Weiyu Chen, Zhe Tang   +10 more
wiley   +1 more source

Identification of Three Potential circRNA Biomarkers of Polycystic Ovary Syndrome by Bioinformatics Analysis and Validation

International Journal of General Medicine, 2021
Pengyu Huang,* Shengrong Du,* Yunhong Lin,* Zhiqing Huang, Haiyan Li, Gangxin Chen, Suzhu Chen, Qingfen Chen, Lincui Da, Hang Shi, Wei Wei, Lei Yang, Yan Sun, Beihong Zheng Reproductive Medicine Center, Fujian Maternity and Child Health ...
Huang P, Du S, Lin Y, Huang Z, Li H, Chen G, Chen S, Chen Q, Da L, Shi H, Wei W, Yang L, Sun Y, Zheng B   +13 more
doaj  

Extraction, Purification and Evaluation of Bioactivity of Lovastatin From Monascus purpureus Fermented Finger Millet

Food Safety and Health, EarlyView.
A graphical abstract showing lovastatin extraction from Monascus purpureus fermented finger millet. ABSTRACT Red yeast rice (RYR), a traditional fermented food product derived from Monascus purpureus cultivation on rice, has been utilized as both food and food additive throughout East Asian countries for centuries.
Monu Kumar, Gaurav Chaudhary, Anita Rani Sehrawat   +2 more
wiley   +1 more source

FROM EPIGENETICS TO ANTI-DOPING APPLICATION: A NEW TOOL OF DETECTION [PDF]

, 2017
Eukaryotic genomes transcribe up to 90% of the genomic DNA but only 1\u20132% of these transcripts encode for proteins, whereas the vast majority are transcribed as non-coding RNAs (ncRNAs). They are divided into short ncRNA, particularly microRNA (miRNA)
Cieszczyk, P., Contro', V., Macchiarella, A., Proia, P., Sacco, A., Schiera, G.   +5 more
core   +1 more source

The circRNA–microRNA code: emerging implications for cancer diagnosis and treatment

Molecular Oncology, 2019
Circular RNAs (circRNAs) comprise an emerging new class of endogenous RNAs expressed abundantly by the eukaryotic transcriptome. They are characterized by a covalently closed loop structure, resulting in RNA molecules that are more stable than linear ...
L. Verduci, S. Strano, Y. Yarden, G. Blandino   +3 more
semanticscholar   +1 more source

CircRNA hsa_circRNA_104348 promotes hepatocellular carcinoma progression through modulating miR-187-3p/RTKN2 axis and activating Wnt/β-catenin pathway

Cell Death and Disease, 2020
Circular RNAs (circRNAs) have confirmed to participate in diverse biological functions in cancer. However, the expression patterns of circRNAs on hepatocellular carcinoma (HCC) remains unclear.
Guanqun Huang, Min Liang, Haiyan Liu, Jianhong Huang, Pei-Yu Li, Chongchong Wang, Yidan Zhang, Ye Lin, Xianhan Jiang   +8 more
semanticscholar   +1 more source