Results 31 to 40 of about 52,173 (326)

Mechanism and Role of circRNA in Occurrence and Development of Hepatocellular Carcinoma

Zhongliu Fangzhi Yanjiu, 2022
Hepatocellular carcinoma (HCC) is the most common pathological type of primary liver cancer, with high fatality rate. The pathogenesis of HCC is complex, and the specific occurrence and development mechanism is still in the exploratory stage.
ZHOU Hong, ZHANG Haibo, YAN Ruijuan, WEI Hailiang, YAN Shuguang, LI Jingtao, CHANG Zhanjie   +6 more
doaj   +1 more source

CircRNA expression profile and circRNA-miRNA-mRNA crosstalk in allergic rhinitis [PDF]

World Allergy Organization Journal, 2020
Circular RNAs (circRNAs) are involved in inflammation; however, their role in allergic rhinitis (AR) remains unclear. In this study, we analyzed circRNA expression and identified a circRNA-miRNA-mRNA network through which circRNAs regulate AR pathogenesis.We analyzed circRNA, miRNA, and mRNA expression profiles in the nasal mucosa by high-throughput ...
Chang-Yu Qiu, Xin-Yan Cui, Mei-Ping Lu, Min Yin, Wan-Yun Xu, Xin-Jie Zhu, Qing Yang, Lei Cheng   +7 more
openaire   +3 more sources

A circulating panel of circRNA biomarkers for the noninvasive and early detection of pancreatic ductal adenocarcinoma.

Gastroenterology, 2023
BACKGROUND & AIMS Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal malignancies. Delayed manifestation of symptoms and the lack of specific diagnostic markers lead to diagnosing PDAC patients at advanced stages.
Caiming Xu, E. Jun, Y. Okugawa, Y. Toiyama, E. Borazanci, John Bolton, A. Taketomi, Song Cheol Kim, Dong Shang, Daniel Von Hoff, Guixin Zhang, A. Goel   +11 more
semanticscholar   +1 more source

CircRNAs in lifespan [PDF]

Nature Reviews Molecular Cell Biology, 2020
Increased expression of the circular RNA generated by the sulfateless gene (circSfl), and of the protein it encodes, can extend the lifespan of flies.
openaire   +2 more sources

NOVA2 regulates neural circRNA biogenesis [PDF]

Nucleic Acids Research, 2021
Abstract Circular RNAs (circRNAs) are highly expressed in the brain and their expression increases during neuronal differentiation. The factors regulating circRNAs in the developing mouse brain are unknown. NOVA1 and NOVA2 are neural-enriched RNA-binding proteins with well-characterized roles in alternative splicing.
David Knupp, Daphne A. Cooper, Yuhki Saito, Robert B. Darnell, Pedro Miura   +4 more
openaire   +3 more sources

CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR

Journal of Hematology & Oncology, 2022
Background Circular RNAs (circRNAs) represent a novel type of regulatory RNA characterized by high evolutionary conservation and stability. CircRNAs are expected to be potential diagnostic biomarkers and therapeutic targets for a variety of malignancies.
Xiaolong Wang, Tong Chen, Chen Li, Wenhao Li, Xianyong Zhou, Yaming Li, Dan Luo, Ning Zhang, Bing Chen, Lijuan Wang, Wenjing Zhao, Shanji Fu, Qifeng Yang   +12 more
semanticscholar   +1 more source

CircRNAs: Insights into Gastric Cancer [PDF]

Gastrointestinal Tumors, 2021
<b><i>Background:</i></b> Gastric cancer (GC) is recorded as the fifth most common cancer globally. The classic resemblance of early symptoms of chronic gastritis including nausea, dysphagia, and dyspepsia with GC is the current challenge limiting the early diagnosis of GC. The current diagnostic procedures of GC are limited due
Sanjana, Rajgopal, Sherine Joanna, Fredrick, Venkatachalam Deepa, Parvathi   +2 more
openaire   +2 more sources

Knockdown of circ_0001273 inhibits the proliferation, migration and invasion of oral squamous cell carcinoma cells

口腔疾病防治, 2020
Objective To explore the effect of circ_0001273 on the proliferation, migration and invasion of oral squamous cell carcinoma（OSCC） cells and to provide a relevant research basis for the use of targeted therapy in OSCC.
ZENG Fantao, YU Dongsheng
doaj   +1 more source

circ-CFH promotes the development of HCC by regulating cell proliferation, apoptosis, migration, invasion, and glycolysis through the miR-377-3p/RNF38 axis

Open Life Sciences, 2022
Circular RNAs (circRNAs) have previously been confirmed to function as vital regulators in multiple human cancers, including hepatocellular carcinoma (HCC). This study aimed to clarify the role and underlying molecular mechanisms of circ-CFH in HCC. circ-
Chen Zengyin, Du Juan, Yang Chen, Si Guangju, Chen Yuxin   +4 more
doaj   +1 more source

Identification of CircRNA signature associated with tumor immune infiltration to predict therapeutic efficacy of immunotherapy

Nature Communications, 2023
Circular RNAs are known to be linked to cancer regulation. Here, the authors identify a circular RNA signature associated with immune checkpoint response in melanoma. Circular RNAs (circRNAs) play important roles in the regulation of cancer. However, the
Yu Dong, Qian Gao, Yong Chen, Zhao Zhang, Yanhua Du, Yuan Liu, Guangxiong Zhang, Shengli Li, Gaoyang Wang, Xiang Chen, Hong Liu, Leng Han, Youqiong Ye   +12 more
semanticscholar   +1 more source