Results 41 to 50 of about 45,661 (289)

Identification of a lncRNA/circRNA-miRNA-mRNA ceRNA Network in Alzheimer's Disease

Journal of Integrative Neuroscience, 2023
Background: Alzheimer’s disease (AD) occurs in the elderly and pre-elderly, characterized by decline of memory, cognitive dysfunction, impairment of learning capacity, and motor dysfunction.
Lining Su, Yixuan Zhang, Yanbing Wang, Huiping Wei   +3 more
doaj   +1 more source

LncRNAs and CircRNAs in cancer

MedComm, 2022
AbstractIt is well known that noncoding RNAs (ncRNAs) cannot encode proteins, but they can play important regulatory roles in tumors by combining with proteins, RNAs, and DNAs. As more and more studies reveal the important roles and underlying mechanisms of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in cancer, their huge application ...
Xin Yin, Huiran Lin, Lei Lin, Lei Miao, Jing He, Zhenjian Zhuo   +5 more
openaire   +3 more sources

circ-CFH promotes the development of HCC by regulating cell proliferation, apoptosis, migration, invasion, and glycolysis through the miR-377-3p/RNF38 axis

Open Life Sciences, 2022
Circular RNAs (circRNAs) have previously been confirmed to function as vital regulators in multiple human cancers, including hepatocellular carcinoma (HCC). This study aimed to clarify the role and underlying molecular mechanisms of circ-CFH in HCC. circ-
Chen Zengyin, Du Juan, Yang Chen, Si Guangju, Chen Yuxin   +4 more
doaj   +1 more source

Circular RNAs in Cervical Cancer: What are the Prospects?

Креативная хирургия и онкология, 2023
C ervical cancer remains a pressing global health problem, creating a significant health burden for women worldwide. High incidence and mortality rates necessitate further research to unravel its underlying molecular mechanisms and identify new ...
S. A. Begliarzade, R. I. Tamrazov
doaj   +1 more source

CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR

Journal of Hematology & Oncology, 2022
Background Circular RNAs (circRNAs) represent a novel type of regulatory RNA characterized by high evolutionary conservation and stability. CircRNAs are expected to be potential diagnostic biomarkers and therapeutic targets for a variety of malignancies.
Xiaolong Wang, Tong Chen, Chen Li, Wenhao Li, Xianyong Zhou, Yaming Li, Dan Luo, Ning Zhang, Bing Chen, Lijuan Wang, Wenjing Zhao, Shanji Fu, Qifeng Yang   +12 more
semanticscholar   +1 more source

The role of circRNAs in cancers [PDF]

Bioscience Reports, 2017
Circular RNAs (circRNAs) are recently regarded as a naturally forming family of widespread and diverse endogenous noncoding RNAs (ncRNAs) that may regulate gene expression in mammals. At present, above 30000 circRNAs have already been found, with their unique structures to maintain stability more easily than linear RNAs.
Shanliang Zhong, Sujin Yang, Jian Li, He-da Zhang, Xiu Chen, Yunjie He, Ling-Ping Zhu, Siying Zhou, Jianhua Zhao, Jia-Hua Hu, Jun-Chen Hou, Jinhai Tang   +11 more
openaire   +3 more sources

RNA sequencing reveals a regulatory network of circRNA-miRNA-mRNA ceRNA in Wilms tumor

陆军军医大学学报, 2022
Objective To identify the potential circRNA-miRNA-mRNA regulatory networks in Wilms tumor (WT) based on high-throughput RNA sequencing technology and bioinformatics analysis.
XIANG Bin, TIAN Xiaomao, MI Tao, JIN Liming, CHEN Meiling   +4 more
doaj   +1 more source

The Secret Garden of Neuronal circRNAs [PDF]

Cells, 2020
High-throughput transcriptomic profiling approaches have revealed that circular RNAs (circRNAs) are important transcriptional gene products, identified across a broad range of organisms throughout the eukaryotic tree of life. In the nervous system, they are particularly abundant, developmentally regulated, region-specific, and enriched in genes for ...
Gasparini S., Licursi V., Presutti C., Mannironi C.   +3 more
openaire   +5 more sources

Circular RNAs in Clear Cell Renal Cell Carcinoma: Their Microarray-Based Identification, Analytical Validation, and Potential Use in a Clinico-Genomic Model to Improve Prognostic Accuracy [PDF]

, 2019
Circular RNAs (circRNAs) may act as novel cancer biomarkers. However, a genome-wide evaluation of circRNAs in clear cell renal cell carcinoma (ccRCC) has yet to be conducted. Therefore, the objective of this study was to identify and validate circRNAs in
Erbersdobler, Andreas, Fendler, Annika, Franz, Antonia, Jung, Klaus, Jung, Monika, Kilic, Ergin, Ralla, Bernhard, Rochow, Hannah, Stephan, Carsten, Weickmann, Sabine   +9 more
core   +2 more sources

Roles of circRNAs on tumor autophagy [PDF]

Molecular Therapy - Nucleic Acids, 2021
Circular RNAs (circRNAs) are a type of special noncoding RNA. circRNAs are highly stable and are found mainly in the cytoplasm. Most circRNAs are conserved and usually exhibit tissue specificity and timing specificity. In addition to the regulation mode of competitive endogenous RNA (ceRNA), circRNAs can also bind to RNA-binding proteins (RBPs ...
Chen Chen, Wenming Cui, Qin Dang, Zhenqiang Sun, Weitang Yuan   +4 more
openaire   +3 more sources