Results 61 to 70 of about 52,173 (326)

Circ-ZNF609 regulates G1-S progression in rhabdomyosarcoma [PDF]

, 2019
Circular RNAs (circRNAs) represent a class of covalently closed RNAs, derived from non-canonical splicing events, which are expressed in all eukaryotes and often conserved among different species.
Bozzoni, Irene, Colantoni, Alessio, Dattilo, Dario, DI TIMOTEO, Gaia, Dominici, Carlo, Legnini, Ivano, Megiorni, Francesca, Morlando, Mariangela, Rossi, Francesca, Santini, Tiziana   +9 more
core   +1 more source

CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1

Signal Transduction and Targeted Therapy, 2020
Sorafenib is the first-line chemotherapeutic therapy for advanced hepatocellular carcinoma (HCC). However, sorafenib resistance significantly limits its therapeutic efficacy, and the mechanisms underlying resistance have not been fully clarified. Here we
Junjie Xu, Lin Ji, Yuelong Liang, Zhe Wan, Wei Zheng, Xiaomin Song, Kirill Gorshkov, Qiming Sun, Hui Lin, Xue-Yong Zheng, Jiang Chen, Ren’an Jin, X. Liang, X. Cai   +13 more
semanticscholar   +1 more source

Nanopore sequencing of brain-derived full-length circRNAs reveals circRNA-specific exon usage, intron retention and microexons

Nature Communications, 2021
Circular RNA (circRNA) is a class of covalently joined non-coding RNAs with functional roles in a wide variety of cellular processes. Their composition shows extensive overlap with exons found in linear mRNAs making it difficult to delineate their ...
K. Rahimi, M. Venø, D. Dupont, J. Kjems
semanticscholar   +1 more source

Predicting circRNA-Disease Associations Based on circRNA Expression Similarity and Functional Similarity [PDF]

Frontiers in Genetics, 2019
Circular RNAs (circRNAs) are a novel class of endogenous noncoding RNAs that have well-conserved sequences. Emerging evidence has shown that circRNAs can be novel biomarkers or therapeutic targets for many diseases and play an important role in the development of various pathological conditions. Therefore, identifying potential disease-related circRNAs
Yongtian Wang, Chenxi Nie, Tianyi Zang, Yadong Wang   +3 more
openaire   +3 more sources

The non-coding RNA landscape of plasma cell dyscrasias [PDF]

, 2020
Despite substantial advancements have been done in the understanding of the pathogenesis of plasma cell (PC) disorders, these malignancies remain hard-to-treat.
Azab, Kareem A, et al,, Morelli, Eugenio, Rocca, Roberta   +3 more
core   +1 more source

Circular RNAs as novel regulators of β-cell functions in normal and disease conditions. [PDF]

, 2018
There is strong evidence for an involvement of different classes of non-coding RNAs, including microRNAs and long non-coding RNAs, in the regulation of β-cell activities and in diabetes development.
Guay, C., Kjems, J., Laybutt, D.R., Lee, K., Regazzi, R., Rodriguez-Trejo, A., Sobel, J., Stoll, L., Venø, M.T.   +8 more
core   +2 more sources

Coupling and Coordination in Gene Expression Processes with Pre-mRNA Splicing [PDF]

, 2015
A processing is a tightly regulated and highly complex pathway which includes transcription, splicing, editing, transportation, translation and degradation.
Huang, Z, Lee, JTH, Pan, K, Wong, CM
core   +7 more sources

Synthetic circRNA therapeutics: innovations, strategies, and future horizons

MedComm
Small molecule drugs are increasingly emerging as innovative and effective treatments for various diseases, with mRNA therapeutics being a notable representative.
Jingsheng Cai, Zonghao Qiu, William Chi-Shing Cho, Zheng Liu, Shaoyi Chen, Haoran Li, Kezhong Chen, Yun Li, Chijian Zuo, Mantang Qiu   +9 more
semanticscholar   +1 more source

The Potential Role of hsa_circ_0004214 as a Biomarker for Breast Cancer Prognosis [PDF]

Journal of Epigenetics
Breast cancer is the most important cause of cancer-related death among women. Finding cancer management biomarkers may improve cancer management strategies, patient outcomes, and quality of life.
Marzieh Beikzadeh, Mahdieh Salimi
doaj   +1 more source

Circulating cell-free nucleic acids: characteristics and applications [PDF]

, 2018
K
Biró, Orsolya, Nagy, Bálint, Pös, Ondrej, Szemes, Tomas   +3 more
core   +1 more source