Results 61 to 70 of about 45,661 (289)
Plasma circRNAs as Biomarkers in Cancer
Cancer Management and Research, 2021 The incidence and mortality of cancer are increasing each year. At present, the sensitivity and specificity of the blood biomarkers that were used in clinical practice are low, which make the detection rate of cancer decrease. With advances in bioinformatics and technology, some non-coding RNA as biomarkers can be easily detected through some ...
Qian Zhou +5 more
openaire +5 more sources
CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1
Signal Transduction and Targeted Therapy, 2020 Sorafenib is the first-line chemotherapeutic therapy for advanced hepatocellular carcinoma (HCC). However, sorafenib resistance significantly limits its therapeutic efficacy, and the mechanisms underlying resistance have not been fully clarified. Here we
Junjie Xu +13 more
semanticscholar +1 more source
The Nefarious Nexus of Noncoding RNAs in Cancer [PDF]
, 2018 The past decade has witnessed enormous progress, which has seen the noncoding RNAs (ncRNAs) turn from the so called dark matter RNA to critical functional molecules, influencing most physiological processes in development and disease contexts.
Anastasiadou, Eleni +3 more
core +1 more source
Molecular Cancer, 2020 Increasing studies have shown that circRNA is closely related to the carcinogenesis and development of many cancers. However, biological functions and the underlying molecular mechanism of circRNAs in triple-negative breast cancer (TNBC) remain largely ...
Xiaying Zheng +7 more
semanticscholar +1 more source
The roles of circRNA–miRNA–mRNA networks in the development and treatment of osteoporosis
Frontiers in Endocrinology, 2022 Osteoporosis is a systemic metabolic disease, mainly characterized by reduced bone mineral density and destruction of bone tissue microstructure. However, the molecular mechanisms of osteoporosis need further investigation and exploration.
Manqi Gao +4 more
semanticscholar +1 more source
Circle the Cardiac Remodeling With circRNAs [PDF]
Frontiers in Cardiovascular Medicine, 2021 Cardiac remodeling occurs after the heart is exposed to stress, which is manifested by pathological processes such as cardiomyocyte hypertrophy and apoptosis, dendritic cells activation and cytokine secretion, proliferation and activation of fibroblasts, and finally leads to heart failure.
Tiqun Yang +12 more
openaire +4 more sources
Journal of Innate Immunity, 2023 Introduction: CircRNAs are closely related to many human diseases; however, their role in acne remains unclear. This study aimed to determine the role of hsa_circ_0102678 in regulating inflammation of acne.
Meng Zhou +11 more
doaj +1 more source
Circular RNAs (circRNAs) in Health and Disease [PDF]
, 2017 This is the final version of the article. Available from MDPI via the DOI in this record.Splicing events do not always produce a linear transcript. Circular RNAs (circRNAs) are a class of RNA that are emerging as key new members of the gene regulatory ...
Haque, S, Harries, LW
core +2 more sources
Roles of CircRNAs in Autoimmune Diseases [PDF]
Frontiers in Immunology, 2019 Circular RNAs (circRNAs) are covalently linked single-stranded RNAs, compared to linear counterparts that are relatively abundant, conserved, stable, and specific. Previously, most studies have revealed that circRNAs function in gene expression processes and participate in the pathogenesis of cancers, cardiovascular diseases, and neurological diseases.
Xin Xia +4 more
openaire +3 more sources
CircRNA: a rising star in leukemia
PeerJ, 2023 Non-coding RNA are a class of RNA that lack the potential to encode proteins. CircRNAs, generated by a post-splicing mechanism, are a newly discovered type of non-coding RNA with multi-functional covalent loop structures. CircRNAs may play an important role in the occurrence and progression of tumors.
Qianan Li +3 more
openaire +3 more sources