Results 71 to 80 of about 20,415 (303)
Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment
Communications BiologyClaudins are a 27-member family of ~25 kDa membrane proteins that integrate into tight junctions to form molecular barriers at the paracellular spaces between endothelial and epithelial cells.
Satchal K. Erramilli +4 more
doaj +1 more source
Frontiers in Physiology, 2019 The density of intestinal mast cells has been reported to increase during inflammatory bowel disease (IBD). As mast cell mediators are known to increase the permeability of epithelial tight junctions, we hypothesized that antigen responses in sensitized ...
Jasmin Becker +2 more
doaj +1 more source
Expression of claudins in the normal canine gastric mucosa [PDF]
, 2013 The aim of the present study was to investigate the expression pattern of claudin-1, -2, -3, -4, -5, -7, -8, -10 and -18 in the intact fundic and pyloric gastric mucosa of dogs.
Balka, Gyula +5 more
core +1 more source
Advanced Science, EarlyView.This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang +9 more
wiley +1 more source
eLife, 2020 Loss of ESCRT function in Drosophila imaginal discs is known to cause neoplastic overgrowth fueled by mis-regulation of signaling pathways. Its impact on junctional integrity, however, remains obscure.
Hendrik Pannen, Tim Rapp, Thomas Klein
doaj +1 more source
The importance of claudin-7 palmitoylation on membrane subdomain localization and metastasis-promoting activities [PDF]
, 2015 Background: Claudin-7 (cld7), a tight junction (TJ) component, is also found basolaterally and in the cytoplasm. Basolaterally located cld7 is enriched in glycolipid-enriched membrane domains (GEM), where it associates with EpCAM (EpC).
Heiler, Sarah +3 more
core +1 more source
Archives of Pathology & Laboratory Medicine, 2022 Context.— Claudin-18 is expressed in some gastric cancers. Clinical trials are evaluating it as a therapeutic target. Objectives.— To evaluate claudin-18 expression in intestinal metaplasia, dysplasia, and adenocarcinoma of the distal esophagus ...
Mary T. Wong +13 more
openaire +1 more source
Advanced Science, EarlyView.The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan +16 more
wiley +1 more source
Rapid eradication of colon carcinoma by Clostridium perfringens Enterotoxin suicidal gene therapy [PDF]
, 2017 Background Bacterial toxins have evolved to an effective therapeutic option for cancer therapy. The Clostridium perfringens enterotoxin (CPE) is a pore- forming toxin with selective cytotoxicity. The transmembrane tight junction proteins claudin-3 and -4
Aumann, Jutta +6 more
core +5 more sources
Advanced Science, EarlyView.This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao +18 more
wiley +1 more source