Results 71 to 80 of about 20,395 (312)
The role of renal transporters and novel regulatory interactions in the TAL that control blood pressure [PDF]
, 2017 Hypertension (HTN), a major public health issue is currently the leading factor in the global burden of disease, where associated complications account for 9.4 million deaths worldwide every year (98).
Dominiczak, Anna +2 more
core +1 more source
Annual Review of Physiology, 2013 Claudins are tight junction membrane proteins that regulate paracellular permeability of renal epithelia to small ions, solutes, and water. Claudins interact within the cell membrane and between neighboring cells to form tight junction strands and constitute both the paracellular barrier and the pore.
Jianghui, Hou +2 more
openaire +2 more sources
Advanced Science, EarlyView.Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong +12 more
wiley +1 more source
Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment
Communications BiologyClaudins are a 27-member family of ~25 kDa membrane proteins that integrate into tight junctions to form molecular barriers at the paracellular spaces between endothelial and epithelial cells.
Satchal K. Erramilli +4 more
doaj +1 more source
Frontiers in Physiology, 2019 The density of intestinal mast cells has been reported to increase during inflammatory bowel disease (IBD). As mast cell mediators are known to increase the permeability of epithelial tight junctions, we hypothesized that antigen responses in sensitized ...
Jasmin Becker +2 more
doaj +1 more source
Antioxidants, 2022 The present study was a part of a larger research project that aimed to investigate the effects of Met-Met supplementation on fish growth and intestinal health. This study mainly focused on the relationship between dietary Met-Met and intestinal physical
Pei Wu +8 more
doaj +1 more source
Celiac Disease: Role of the Epithelial Barrier [PDF]
, 2017 In celiac disease (CD) a T-cell–mediated response to gluten is mounted in genetically predisposed individuals, resulting in a malabsorptive enteropathy histologically highlighted by villous atrophy and crypt hyperplasia.
Fromm, Michael +3 more
core +1 more source
The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia
Advanced Science, EarlyView.The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo +3 more
wiley +1 more source
Intestinal Barrier, Claudins and Mycotoxins
Toxins, 2021 The intestinal barrier is the main barrier against all of the substances that enter the body. Proper functioning of this barrier guarantees maintained balance in the organism. Mycotoxins are toxic, secondary fungi metabolites, that have a negative impact
Marta Justyna Kozieł +2 more
doaj +1 more source
Archives of Pathology & Laboratory Medicine, 2022 Context.— Claudin-18 is expressed in some gastric cancers. Clinical trials are evaluating it as a therapeutic target. Objectives.— To evaluate claudin-18 expression in intestinal metaplasia, dysplasia, and adenocarcinoma of the distal esophagus ...
Mary T. Wong +13 more
openaire +1 more source