A Novel Variant in CMAH Is Associated with Blood Type AB in Ragdoll Cats. [PDF]
PLoS ONE, 2016 The enzyme cytidine monophospho-N-acetylneuraminic acid hydroxylase is associated with the production of sialic acids on cat red blood cells. The cat has one major blood group with three serotypes; the most common blood type A being dominant to type B. A
Barbara Gandolfi +9 more
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Inactivation of the CMAH gene and deficiency of Neu5Gc play a role in human brain evolution [PDF]
Inflammation and RegenerationDuring human evolution, some genes were lost or silenced from the genome of hominins. These missing genes might be the key to the evolution of humans’ unique cognitive skills. An inactivation mutation in CMP-N-acetylneuraminic acid hydroxylase (CMAH) was
Yuxin Liu, Jinhong Li, Qicai Liu
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CMAH Coding Sequence Variants in 15 Non-Domestic Felid Species Related to ABC Blood Group System [PDF]
AnimalsDifferent blood group systems have been characterized in people and other mammals. In domestic cats, the ABC blood group system plays the most important clinical role and has been investigated extensively—from the phenotype to the molecular genetics.
Alexandra Kehl +6 more
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Elimination of GGTA1, CMAH, β4GalNT2 and CIITA genes in pigs compromises human versus pig xenogeneic immune reactions [PDF]
Animal Models and Experimental MedicineBackground Pig organ xenotransplantation is a potential solution for the severe organ shortage in clinic, while immunogenic genes need to be eliminated to improve the immune compatibility between humans and pigs.
Jing Xu +13 more
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Does Amyotrophic Lateral Sclerosis (ALS) Have Metabolic Causes from Human Evolution? [PDF]
CellsAs so many drugs have failed in ALS a new approach is needed. The author proposes that recent human genetic variants may play major roles in the disease, changing metabolism.
Michael Spedding
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Absence of Neu5Gc and Presence of Anti-Neu5Gc Antibodies in Humans—An Evolutionary Perspective [PDF]
Frontiers in Immunology, 2019 The glycocalyx of human cells differs from that of many other mammals by the lack of the sialic acid N-glycolylneuraminic acid (Neu5Gc) and increased abundance of its precursor N-acetylneuraminic acid (Neu5Ac).
Meghan O. Altman +2 more
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Porcine to Human Heart Transplantation: Is Clinical Application Now Appropriate? [PDF]
Journal of Immunology Research, 2017 Cardiac xenotransplantation (CXTx) is a promising solution to the chronic shortage of donor hearts. Recent advancements in immune suppression have greatly improved the survival of heterotopic CXTx, now extended beyond 2 years, and life-supporting kidney ...
Christopher G. A. McGregor +1 more
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Modern xenotransplantation: rewiring glycan-mediated immunogenicity via genome-glycome convergence [PDF]
EBioMedicineSummary: Xenotransplantation addresses global organ shortages but faces species-specific glycan antigen barriers. Dominant xenoantigens (α-Gal, Neu5Gc, Sda) trigger hyperacute rejection via antibody-mediated immune cascades, complement activation, and ...
Mingshuo Wang +7 more
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The generation and evaluation of TKO/hCD55/hTM/hEPCR gene-modified pigs for clinical organ xenotransplantation [PDF]
Frontiers in ImmunologyIntroductionGenetically edited pigs, modified using CRISPR-Cas9 technology, hold promise as potential sources for xenotransplantation. However, the optimal combination of genetic modifications and their expression levels for initial clinical trials ...
Guoli Huai +12 more
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Chimeric antigen receptor T cells targeting the GM3(Neu5Gc) ganglioside [PDF]
Frontiers in ImmunologyChimeric antigen receptor (CAR) T cell technology has ushered in a new era of immunotherapy, enabling the targeting of a broad range of surface antigens, surpassing the limitations of traditional T cell epitopes.
Julia Heinzelbecker +9 more
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