Results 21 to 30 of about 3,073 (171)

Molecular characterization of cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) gene and frequency of blood types in stray cats of İzmir, Turkey [PDF]

BMC Genomics, 2021
Background Cytidine monophospho-n-acetylneuraminic acid hydroxylase (CMAH) gene associated with blood groups in cats encodes CMAH enzyme that converts Neu5Ac to Neu5Gc.
Hüseyin Can, Sedef Erkunt Alak, Ahmet Efe Köseoğlu, Umut Şahar, Berna Bostanbaş, Serdar Baydarlı, Mert Döşkaya, Cemal Ün   +7 more
doaj   +7 more sources

Molecular characterization of blood type A, B, and C (AB) in domestic cats and a CMAH genotyping scheme. [PDF]

PLoS ONE, 2018
In domestic cats, the AB blood group system consists of the three types A, B, and C (usually called AB), which vary in frequency among breeds and geographic regions.
Alexandra Kehl, Kevin Heimberger, Ines Langbein-Detsch, Sabine Boehmer, Karthik Raj, Elisabeth Mueller, Urs Giger   +6 more
doaj   +4 more sources

Correction: A Novel Variant in CMAH Is Associated with Blood Type AB in Ragdoll Cats. [PDF]

PLoS ONE, 2018
[This corrects the article DOI: 10.1371/journal.pone.0154973.].
Barbara Gandolfi, Robert A Grahn, Nicholas A Gustafson, Daniela Proverbio, Eva Spada, Badri Adhikari, Janling Cheng, Gordon Andrews, Leslie A Lyons, Chris R Helps   +9 more
doaj   +4 more sources

N-linked glycan profiling of GGTA1/CMAH knockout pigs identifies new potential carbohydrate xenoantigens [PDF]

Xenotransplantation, 2015
BACKGROUND: The temporary or long-term xenotransplantation of pig organs into people would save thousands of lives each year if not for the robust human antibody response to pig carbohydrates.
Bern, Marshall, Brito, Alejandro E., Burlak, Christopher, Estrada, Jose L., Isailovic, Dragan, Li, Ping, Tector, A. Joseph, Wang, Zheng-Yu   +7 more
core   +4 more sources

Biocompatibility of Genetically-Engineered Pig Cornea in Corneal Xenotransplantation: Preliminary In Vitro Study. [PDF]

Xenotransplantation
ABSTRACT Introduction We aimed to evaluate biophysical compatibility of corneal endothelial cells in genetically‐engineered (GE) pigs to identify the best candidate for in vivo nonhuman primate (NHP) study and to collect baseline data for future clinical trials from a biological function perspective.
Lee SH, Kim CY, Ryu JS, Choi DH, Yoon CH, Park CG, Choi K, Kim H, Kim MK.   +8 more
europepmc   +2 more sources

Human immune reactivity of GGTA1/CMAH/A3GALT2 triple knockout Yucatan miniature pigs [PDF]

Transgenic Research, 2021
AbstractIn this study, we investigated the effect of a triple knockout of the genes alpha-1,3-galactosyltransferase (GGTA1), cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH), and alpha 1,3-galactosyltransferase 2 (A3GALT2) in Yucatan miniature pigs on human immune reactivity. We used the CRISPR/Cas9 system to create pigs lacking GGTA1 (
Joohyun Shim, Nayoung Ko, Hyoung-Joo Kim, Yongjin Lee, Jeong-Woong Lee, Dong-Il Jin, Hyunil Kim, Kimyung Choi   +7 more
openaire   +2 more sources

Minimal Consequences of CMAH and DBA/2 Backgrounds on a FKRP Deficient Model [PDF]

Journal of Neuromuscular Diseases, 2021
Background: Muscular dystrophies (MD) are a large group of genetic diseases characterized by a progressive loss of muscle. The Latent TGFβ Binding Protein 4 (LTBP4) in the DBA/2 background and the Cytidine Monophosphate-sialic Acid Hydroxylase (CMAH) proteins were previously identified as genetic modifiers in severe MD.
Vaubourg, Camille, Gicquel, Evelyne, Richard, Isabelle, Lostal, William, Bellec, Jessica   +4 more
openaire   +3 more sources

Hydroxylation of N-acetylneuraminic Acid Influences the in vivo Tropism of N-linked Sialic Acid-Binding Adeno-Associated Viruses AAV1, AAV5, and AAV6

Frontiers in Medicine, 2021
Adeno-associated virus (AAV) vectors are promising candidates for gene therapy. However, a number of recent preclinical large animal studies failed to translate into the clinic. This illustrates the formidable challenge of choosing the animal models that
Estrella Lopez-Gordo, Alejandro Orlowski, Arthur Wang, Alan Weinberg, Susmita Sahoo, Thomas Weber, Thomas Weber   +6 more
doaj   +1 more source

Production and Functional Verification of 8-Gene (GGTA1, CMAH, β4GalNT2, hCD46, hCD55, hCD59, hTBM, hCD39)-Edited Donor Pigs for Xenotransplantation. [PDF]

Cell Prolif
Schematic representation of generation of 8‐gene‐edited cloned pigs and their verification by pig to non‐human primate kidney xenotransplantation. ABSTRACT Gene‐edited (GE) pig‐to‐human xenotransplantation continues to make breakthroughs, but which kind of gene combination is suitable for organ‐specific transplantation remains unclear.
Wang J, Xu K, Liu T, Zhao H, Jamal MA, Chen G, Huo X, Yang C, Jiao D, Wei T, Huang H, Zhao H, Guo J, Wang F, Zhang X, Liu K, Qu S, Wang G, Guo H, Chen G, Zhao HY, Zeng Z, Dou K, Wei HJ.   +23 more
europepmc   +2 more sources

Multiple gene editing in porcine embryos using a combination of microinjection, electroporation, and transfection methods [PDF]

Veterinary World, 2022
Background and Aim: Mosaicism – the presence of both wild-type and mutant alleles – is a serious problem for zygotic gene modification through gene editing using the Clustered regularly interspaced short palindromic repeats-Cas9 (CRISPR/ Cas9) system ...
Quynh Anh Le, Manita Wittayarat, Zhao Namula, Qingyi Lin, Koki Takebayashi, Maki Hirata, Fuminori Tanihara, Lanh Thi Kim Do, Takeshige Otoi   +8 more
doaj   +1 more source