Results 31 to 40 of about 3,073 (171)

Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) Gene Associated with the Feline AB Blood Group System. [PDF]

PLoS ONE, 2016
Cat's AB blood group system (blood types A, B, and AB) is of major importance in feline transfusion medicine. Type A and type B antigens are Neu5Gc and Neu5Ac, respectively, and the enzyme CMAH participating in the synthesis of Neu5Gc from Neu5Ac is ...
Toshinori Omi, Shota Nakazawa, Chihiro Udagawa, Naomi Tada, Kazuhiko Ochiai, Yong Hwa Chong, Yuiko Kato, Hiroko Mitsui, Azusa Gin, Hitomi Oda, Daigo Azakami, Kyoichi Tamura, Toshinori Sako, Takeshi Inagaki, Atsushi Sakamoto, Toshihiko Tsutsui, Makoto Bonkobara, Shuichi Tsuchida, Shigenori Ikemoto   +18 more
doaj   +1 more source

Phenotypic and Genetic Characterization for Incompatible Cross-Match Cases in the Feline AB Blood Group System

Frontiers in Veterinary Science, 2021
The feline AB blood group system (blood types A, B, and AB) encoding the cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) gene is the most significant in transfusion medicine and hemolysis of the newborn for cats.
Yumiko Uno, Masami Yaguchi, Tasuku Kobayashi, Eri Onozawa, Kazuhiko Ochiai, Kazuhiko Ochiai, Karin Yoshida, Chihiro Nakamura, Chihiro Udagawa, Toshinori Omi, Toshinori Omi   +10 more
doaj   +1 more source

An In Silico Functional Analysis of Non-Synonymous Single-Nucleotide Polymorphisms of Bovine CMAH Gene and Potential Implication in Pathogenesis

Pathogens, 2023
The sugar molecule N-glycolylneuraminic acid (Neu5Gc) is one of the most common sialic acids discovered in mammals. Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) catalyses the conversion of N-acetylneuraminic acid (Neu5Ac) to Neu5Gc ...
Oluwamayowa Joshua Ogun, Opeyemi S. Soremekun, Georg Thaller, Doreen Becker   +3 more
doaj   +1 more source

Peptide-conjugated phosphodiamidate oligomer-mediated exon skipping has benefits for cardiac function in mdx and Cmah-/-mdx mouse models of Duchenne muscular dystrophy. [PDF]

PLoS ONE, 2018
Cardiac failure is a major cause of mortality in patients with Duchenne muscular dystrophy (DMD). Antisense-mediated exon skipping has the ability to correct out-of-frame mutations in DMD to produce truncated but functional dystrophin.
Alison M Blain, Elizabeth Greally, Graham McClorey, Raquel Manzano, Corinne A Betts, Caroline Godfrey, Liz O'Donovan, Thibault Coursindel, Mike J Gait, Matthew J Wood, Guy A MacGowan, Volker W Straub   +11 more
doaj   +1 more source

An Overview of the Importance and Value of Porcine Species in Sialic Acid Research

Biology, 2022
Humans frequently interact with pigs, whose meat is also one of the primary sources of animal protein. They are one of the main species at the center of sialic acid (Sia) research.
Oluwamayowa Joshua Ogun, Georg Thaller, Doreen Becker   +2 more
doaj   +1 more source

Phylogenetic Distribution of CMP-Neu5Ac Hydroxylase (CMAH), the Enzyme Synthetizing the Proinflammatory Human Xenoantigen Neu5Gc [PDF]

Genome Biology and Evolution, 2017
The enzyme CMP-N-acetylneuraminic acid hydroxylase (CMAH) is responsible for the synthesis of N-glycolylneuraminic acid (Neu5Gc), a sialic acid present on the cell surface proteins of most deuterostomes. The CMAH gene is thought to be present in most deuterostomes, but it has been inactivated in a number of lineages, including humans.
Peri, Sateesh, Kulkarni, Asmita, Feyertag, Felix, Berninsone, Patricia M., Alvarez-Ponce, David   +4 more
openaire   +4 more sources

Overdose intake of Neu5Gc triggers colorectal inflammation and alters liver metabolism

Food and Agricultural Immunology, 2023
A positive correlation between massive red meat consumption with colorectal cancer had been reported. Given the complexity of meat components, we focused on investigating the role of Neu5Gc in human healthy.
Teng Yuan, Peidong Yang, Anjing Zhang, Jing Li, Ziyin Han, Shuqi Yang, Yihamu Jimu, Fanli Kong, Dengke Pan, Keren Long, Mingzhou Li, Lu Lu   +11 more
doaj   +1 more source

An Efficacious Transgenic Strategy for Triple Knockout of Xeno-Reactive Antigen Genes GGTA1, CMAH, and B4GALNT2 from Jeju Native Pigs

Vaccines, 2022
Pigs are promising donors of biological materials for xenotransplantation; however, cell surface carbohydrate antigens, including galactose-alpha-1,3-galactose (α-Gal), N-glycolylneuraminic acid (Neu5Gc), and Sd blood group antigens, play a significant ...
Seungwon Yoon, Seulgi Lee, Chungyu Park, Hyunyong Choi, Minwoo Yoo, Sang Chul Lee, Cheol-Ho Hyun, Nameun Kim, Taeyoung Kang, Eugene Son, Mrinmoy Ghosh, Young-Ok Son, Chang-Gi Hur   +12 more
doaj   +1 more source

Highly efficient multiplex genetic engineering of porcine primary fetal fibroblasts

Surgery Open Science, 2021
Background: Genetically engineered porcine donors are a potential solution for the shortage of human organs for transplantation. Incompatibilities between humans and porcine donors are largely due to carbohydrate xenoantigens on the surface of porcine ...
Benjamin Klapholz, PhD, Heather Levy, Ramesh Kumbha, PhD, Nora Hosny, Michael E. D'Angelo, PhD, Bernhard J. Hering, MD, Christopher Burlak, PhD   +6 more
doaj   +1 more source

Triple gene editing in porcine embryos using electroporation alone or in combination with microinjection [PDF]

Veterinary World, 2022
Background and Aim: We previously developed the gene-editing by electroporation (EP) of Cas9 protein method, in which the CRISPR/Cas9 system was introduced into porcine in vitro fertilized (IVF) zygotes through EP to disrupt a target gene.
Zhao Namula, Quynh Anh Le, Manita Wittayarat, Qingyi Lin, Koki Takebayashi, Maki Hirata, Lanh Thi Kim Do, Fuminori Tanihara, Takeshige Otoi   +8 more
doaj   +1 more source