Frontiers in Immunology, 2022 Chimeric antigen receptor (CAR) T cells have emerged as a powerful immunotherapeutic tool against certain hematological malignancies but a significant proportion of patients either do not respond or they relapse, sometimes as a result of target antigen ...
Elisabetta Cribioli +3 more
doaj +1 more source
Synthesis of N-Glycolylneuraminic Acid (Neu5Gc) and Its Glycosides. [PDF]
, 2019 Sialic acids constitute a family of negatively charged structurally diverse monosaccharides that are commonly presented on the termini of glycans in higher animals and some microorganisms.
Chen, Xi +2 more
core +2 more sources
Antitumor effects of the GM3(Neu5Gc) ganglioside-specific humanized antibody 14F7hT against Cmah-transfected cancer cells [PDF]
Scientific Reports, 2019 AbstractThe GM3(Neu5Gc) ganglioside represents a tumor-specific antigen that is considered a promising target for cancer immunotherapy. We previously demonstrated that the humanized antibody 14F7hT, specific for this ganglioside, exhibited significant antitumor effects in preclinical hematological tumor models.
Denise Dorvignit +9 more
openaire +3 more sources
Can we extrapolate from a Cmah -/- Ldlr -/- mouse model a susceptibility for atherosclerosis in humans? [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 International ...
Soulillou, Jean-Paul +3 more
openaire +3 more sources
Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera. [PDF]
PLoS Pathogens, 2018 While infectious agents have typical host preferences, the noninvasive enteric bacterium Vibrio cholerae is remarkable for its ability to survive in many environments, yet cause diarrheal disease (cholera) only in humans. One key V.
Frederico Alisson-Silva +10 more
doaj +1 more source
Cells, 2021 Transplantation of xenogenic porcine chondrocytes could represent a future strategy for the treatment of human articular cartilage defects. Major obstacles are humoral and cellular rejection processes triggered by xenogenic epitopes like α-1,3-Gal and ...
Hanna Tritschler +7 more
doaj +1 more source
Characterization of antibody binding to swine leukocyte antigen class II [PDF]
, 2016 Indiana University-Purdue University Indianapolis (IUPUI)Though the elimination of carbohydrate xenoantigens has reduced the antibody barrier to clinical xenotransplantation, identification of additional targets of rejection could further increase the ...
Ladowski, Joseph Matthew
core +1 more source
The Inhibitory Effect of Early Pregnancy Factor on Red Meat Neu5Gc-Mediated Antibody Production in CMAH-/- Mice. [PDF]
NutrientsThe meat derived from mammals such as cows, sheep, and pigs is commonly referred to as red meat. Recent studies have shown that consuming red meat can activate the immune system, produce antibodies, and subsequently develop into tumors and cancer. This is due to the presence of a potential carcinogenic compound in red meat called N-ethanol neuraminic ...
Wang C +12 more
europepmc +3 more sources
Whole blood transcriptome analysis of Mycoplasma mycoides subsp mycoides-infected cattle confirms immunosuppression but does not reflect local inflammation [PDF]
, 2015 Contagious bovine pleuropneumonia (CBPP), caused by Mycoplasma mycoides subsp. mycoides (Mmm), is a severe respiratory disease of cattle responsible for major economic losses in sub-Saharan Africa.
Holzmuller, Philippe +5 more
core +7 more sources
International Journal of Molecular Sciences, 2022 Duchenne muscular dystrophy (DMD) is a degenerative genetic myopathy characterized by complete absence of dystrophin. Although the mdx mouse lacks dystrophin, its phenotype is milder compared to DMD patients. The incorporation of a null mutation in the Cmah gene led to a more DMD-like phenotype (i.e., more fibrosis).
Paul Ritter +10 more
openaire +5 more sources