Results 81 to 90 of about 2,048 (142)
Cancer Science, Volume 116, Issue 5, Page 1405-1416, May 2025.MCM8‐9 functions in the repair of double‐strand breaks induced by replication stress, which is typically elevated in cancer cells. The authors developed an amido‐bridged nucleic acid‐modified gapmer antisense oligonucleotide, termed ASO 8–3419, to inhibit MCM8.
Yuki Uchibori +6 more
wiley +1 more source
The mechanism of eukaryotic CMG helicase activation
, 2020 The initiation of eukaryotic DNA replication occurs in two discrete stages: first, the minichromosome maintenance (MCM) complex assembles as a head-to-head double hexamer that encircles duplex replication origin DNA during G1 phase; then, 'firing factors'
Ferdos Abid Ali (8307117) +3 more
core
Advanced Science, Volume 12, Issue 14, April 10, 2025.This study elucidates the mechanism underlying LINC01235 promotes clonal evolution and selection under treatment pressure by facilitating DNA replication licensing and CIN, leading to increased therapeutic resistance in HER2+ breast cancer. Targeting LINC01235‐related pathways with ATR inhibitors may be a viable strategy for clinical application ...
Qi Zhang +18 more
wiley +1 more source
G3: Genes, Genomes, Genetics, 2016 Cullin-RING E3-Ligases (CRLs), the largest family of E3 ubiquitin-Ligases, regulate diverse cellular processes by promoting ubiquitination of target proteins.
Batool Ossareh-Nazari +3 more
doaj +1 more source
Oligonucleotide therapeutics in sports? An antidoping perspective
Archiv der Pharmazie, Volume 358, Issue 1, January 2025.Several gene therapies including oligonucleotide therapeutics have been approved during the last 20 years. In sports, the use of nucleic acids or nucleic acid analogs is prohibited. This review discusses types of oligonucleotide therapeutics, their potential to be misused in sports, and considerations to sample preparation and mass spectrometric ...
Maria K. Parr, Annekathrin M. Keiler
wiley +1 more source
A Decade of Discovery—Eukaryotic Replisome Disassembly at Replication Termination
BiologyThe eukaryotic replicative helicase (CMG complex) is assembled during DNA replication initiation in a highly regulated manner, which is described in depth by other manuscripts in this Issue.
Rebecca M. Jones +2 more
doaj +1 more source
Visualizing Volumetric and Segmentation Data using Mol* Volumes & Segmentations 2.0
Current Protocols, Volume 4, Issue 12, December 2024.Abstract Ever‐increasing availability of experimental volumetric data (e.g., in .ccp4, .mrc, .map, .rec, .zarr, .ome.tif formats) and advances in segmentation software (e.g., Amira, Segger, IMOD) and formats (e.g., .am, .seg, .mod, etc.) have led to a demand for efficient web‐based visualization tools.
Aliaksei Chareshneu +3 more
wiley +1 more source
A common mechanism for recruiting the Rrm3 and RTEL1 accessory helicases to the eukaryotic replisome
The EMBO JournalThe eukaryotic replisome is assembled around the CMG (CDC45-MCM-GINS) replicative helicase, which encircles the leading-strand DNA template at replication forks.
Ottavia Olson +3 more
doaj +1 more source
eLife, 2015 We have reconstituted a eukaryotic leading/lagging strand replisome comprising 31 distinct polypeptides. This study identifies a process unprecedented in bacterial replisomes.
Roxana E Georgescu +7 more
doaj +1 more source